Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 68 for “"Pentose phosphate pathway."”.
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Systems biology approach to understanding the control of glucose metabolism in healthy and apoptotic neurons
… Kinetic stimulation of the oxidative pentose phosphate pathway by apoptosis was a major contributor to the decrease in glycolysis, while kinetic inhibition of mitochondrial phosphorylation was a major contributor to the decrease in mitochondrial substrate oxidation. Direct inhibition …
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Metabolic vulnerability in HER2-positive Breast Cancer
… encoding a metabolic enzyme in the non-oxidative pentose phosphate pathway was identified from the screen. Metabolic profiling with isotope-labeled glucose was used to understand the mechanism. The profiling results indicated that TALDO1 was necessary for cellular NADPH generation to combat …
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Understanding and modulating macrophage metabolism for improving inflammatory functions against Trypanosoma cruzi infection
… and nitric oxide, in which the shunt to the pentose phosphate pathway is important for oxidative species generation and suppressing T. cruzi survival and replication. Contrary to our expectations, inhibition of PPAR-α and mitochondrial pyruvate transport moderately suppressed oxidative …
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Interrogating and potentiating energy metabolism in the human brain after traumatic brain injury
… used 1,2-13C2 glucose to measure glycolysis and pentose phosphate pathway activity. Glycolysis is the dominant lactate-producing pathway but the pentose phosphate pathway also contributes and is increased in some TBI patients. Study IV: I used arterio-venous gradients to measure glucose and …
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Biosynthetic and structural studies of neomycin and berninamycin
… be explained when 3 is first shunted through the pentose phosphate pathway to form primary metabolites of different carbon length. Some of these metabolites are then reconstituted back to six-carbon unit for the biosynthesis of 2.
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ELUCIDATION ON THE MECHANISM OF CAMKKα AS A PRO-GROWTH KINASE IN MOUSE SKELETAL MUSCLE
… 2) is necessary and sufficient for maximal pentose phosphate pathway (a metabolic pathway that utilizes glucose to produce ribose-5-phosphate, which is necessary for nucleotide synthesis) flux, during muscle growth, and 3) putatively phosphorylates 8 newly identified protein substrates, …
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Phosphoglucomutase 1 (PGM1) expression and regulation in cancer cells
… of the glycogen breakdown product, glucose-1-phosphate into glucose-6-phosphate, a substrate for glycolysis and the pentose phosphate pathway. This places PGM1 at a critical traffic point of glucose metabolism. In this study we investigated the expression, regulation and biological …
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Gluconeogenic FBP1 plays a key metabolic role in activated T cells
… in gluconeogenesis that converts fructose-1,6-bisphosphate (F1,6BP) to fructose-6-phosphate (F6P). It is active in liver, kidney and skeletal muscle cells. This study suggests that FBP1 plays a novel non-gluconeogenic role in T cells. Targeted metabolomics using [13C]-6-glucose revealed a labeling …
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Expression Analysis of the Imprinted Gene Transketolase-like 1 in Mouse and Human
… functions in the nonoxidative branch of the pentose phosphate pathway (PPP), which maintains glutathione in a reduced state through the generation of NADPH. Previous studies on transaldolase, the other critical enzyme in the nonoxidative branch of the PPP, suggest that TKTL1 may affect the …
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An updated genome scale metabolic reconstruction of methanosarcina barkeri
… has shed light on previously unclear metabolic pathways. For methanogenesis, proton pumping has been updated to reflect an improved knowledge of the pathway. Cofactor biosynthesis has been updated to reflect a better understanding of methanogen anabolism. Metabolic networks such as pentose …
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Glucose-6-Phosphatase in Metabolic Disease and Cancer
… are assumed to be consequences of glucose-6-phosphate accumulation, although the mechanism has not been explored in detail. Late sequela of GSD1a includes the formation of liver adenomas and carcinomas without obvious signs of liver injury or cirrhosis. Here we show that the oncogenic …
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Designing high-performance yeast factories for the production of high-value aromatics based on a novel species and its consortia
… from non-balanced and low throughput metabolic pathways.</p> <p>Looking beyond S. cerevisiae, many non-conventional yeasts possess highly desirable traits that are obtained through long term evolution in particular environment but challenging to be horizontally transferred to model hosts without …
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Computational modeling techniques for biological network productivity increases : optimization and rate-limiting reaction detection
… fine-tuned flux partition between glycolysis pathway and the pentose phosphate pathway. The S. cerevisiae version is more sophisticated with the incorporated dynamics of the NAD/NADH and NADP/NADPH, as well as the automatic switch from aerobic to anaerobic condition. It was applied to maximize …
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Methodologies and analysis of metabolic flux in mammalian systems
… interaction from one-carbon metabolism to pentose phosphate pathway and TCA cycle. In isotope-infused mice, the new MFA framework directly measured systemic glucose and lactate contribution to TCA cycle under physiological condition, which confirms the conventional knowledge that glucose is …
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Upregulation of Cystathionine-β-synthase in Colonic Epithelia Reprograms Metabolism and Promotes Carcinogenesis
… catalyzes the first step of the transsulfuration pathway converting homocysteine to cystathionine. CBS and the subsequent production of H2S are selectively upregulated in human colon cancer compared to patient matched normal margin mucosa. CBS produced H2S enhances cancer cell bioenergetics, tumor …
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Ferroptosis: A Novel Form of Cancer Cell Death Induced by the Small Molecule Erastin
… depends upon activity of NADPH oxidase-1 and pentose phosphate pathway-derived NADPH.
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Study of Erythroid Antioxidant Depletion in Childhood Obesity
… capacity to generate reducing power through the pentose phosphate pathway, catalase post-translational modifications, and exacerbated oxidase activity. These results were largely reflected at the metallomics level, since study subjects with obesity had decreased blood levels of essential elements …
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Identification and analysis of Arabidopsis thiamine pyrophosphate transporters
Thiamine pyrophosphate (TPP) serves as a cofactor in universal metabolic pathways, including glycolysis, the pentose phosphate pathway (PPP) and the tricarboxylic acid cycle; moreover, it is essential for the proper functioning of all organisms. Recently, several steps of the plant thiamine …
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Design, manufacture, and application of DNA microarrays to study gene expression phenotypes of lysine-producing Corynebacterium glutamicum
… the transcriptional profile of the genes of pathways involved in central carbon metabolism and lysine biosynthesis. It was found that to ensure arrays of high quality, protocols applying the arrays should include DNase treatment of RNA samples. additional RNA filtration purification steps, …
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Genetic Engineering of Plant Seeds to Increase Thiamin (Vitamin B1) Content
Thiamine (Vitamin B1) in the form of thiamine pyrophosphate (TPP) is an essential cofactor for the function of numerous enzymes which are involved in central metabolism such as citric acid cycle, pentose phosphate pathway, Calvin cycle, isoprenoid biosynthesis, and branched-chain amino acid …
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