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Showing 1 to 20 of 23 for “"Pentamer"”.
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Synthesis of Highly Ordered Polymer Nanostructures Based on Polyphenylene Vinylenes (PPVs)
… composed of alternating PPV oligomers (trimer, pentamer, or septamer) with flexible (n-decyl or tetraethylene glycol) or rigid linkers (adamantane, diamantane, or azobenzene) were created. Depending on the structure of the PPV chromophore, variations in the polymer chain morphology was found as …
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Mutations in Phospholamban Alter the Structure and Function of the Calcium ATPase Regulatory Complex
… handling and contractility. PLB exists as a homopentamer in the membrane, which upon deoligomerization into active monomers reversibly inhibits sarco/endoplasmic reticulum calcium ATPase (SERCA). Mutations in PLB that change the PLB monomer-pentamer equilibrium result in dysregulation of SERCA. …
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Preparation of Nitrile Containing Siloxane Triblock COpolymers and Their APplication As Stabilizers For Siloxane Magnetic Fluids
… equilibrate are tetramer (8.6 ± 0.7 wt%), pentamer (6.3 ± 0.8 wt%) and hexamer (2.1 ± 0.5 wt%). 2.5k-2.5k-2.5k, 4k-4k-4k, and 8k-8k-8k triblock copolymers were prepared and characterized. These triblock copolymers are transparent, microphase separated and highly viscous liquids. It was …
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Investigating self-assembly of linked oligomeric PPV-based materials
… (RR) and regio-random (RRa) alkoxy-linked pentamer poly(2-methoxy-5-(2’-ethylhexyloxy)-p-phenylenevinylene) (MEH-PPV) illustrates the limited effect of regioregularity of the side chains on self-assembly. Through synthetic structure, it is possible to design highly ordered materials through …
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The Nucleolar Protein Nucleophosmin Undergoes Liquid-Liquid Phase Separation with Arginine-Rich Nucleolar Proteins through Weak, Multivalent Electrostatic Interactions
… organization. Specifically, NPM1 forms a pentamer through its N-terminal oligomerization domain and can bind to rRNA through its C-terminal nucleic acid binding domain. Multiple acidic tracts throughout NPM1, two within an intrinsically disordered region (IDR), confer additional …
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Total Synthesis of Oligomeric Cyclotryptamine Alkaloids
… afforded a highly convergent synthesis of the pentameric alkaloid, allowing its detailed structural assignment. Highlights of the synthesis include the introduction of four quaternary stereocenters with complete stereochemical control in a single step via the photoextrusion of three molecules …
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Selective allodepletion to improve anti-viral and anti-leukaemic responses after haploidentical transplantation
… to unmanipulated PBMCs in both assays. In pentamer and IFN-γ ELISPOT assays, anti-viral responses to CMV, EBV and adenovirus were preserved after combined CD25/71 allodepletion. Finally, we showed that CD25/71 allodepleted T-cells can be redirected to recognize and secrete IFN-γ and …
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Structural, biochemical, and inhibition studies of proline biosynthetic enzymes
… decamer in solution, consistent with the pentamer-of-dimers assembly seen crystallographically. Kinetic and mutational analysis confirmed several features seen in the crystal structure, including the importance of a hydrogen bond between Thr238 and the substrate as well as limited cofactor …
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Comparative Studies of Processivity Clamp Loader ATP Site Function
… mechanism. Clamp loaders are ring-shaped pentamers of AAA+ subunits. The pentamer complex contains 3-4 ATP sites, each located at the interface of two subunits. In each ATP site, an arginine residue from one subunit is located near the γ-phosphate of ATP bound to the adjacent subunit. …
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The Role of Transmembrane Domain Helix-Helix Interactions in the Function of Pentameric Ligand-Gated Ion Channels
The pentameric ligand gated ion channel super family plays a central role in fast synaptic communication between neurons and at the neuromuscular junction. Extensive studies on the prototypic pLGIC, the Torpedo nicotinic acetylcholine receptor (nAChR) have revealed an exquisite lipid sensitivity, …
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Plant-based Multicomponent Vaccines against Enteric Diseases
… of the CFA/I-CTA2 subunit into the CTBNSP4 pentamer was detected by immunoblot and Gmi ELISA assays. The CFA/ICTA2- CTB-NSP4 hetero-hexamer fusion protein complex retained its binding affinity for Gmi ganglioside enterocyte membrane receptors. Serum and intestinal antibodies against NSP4, …
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Development of Quantitative Solid-State NMR Methods to Characterize Membrane Proteins
… bilayers. The transmembrane domain of E forms a pentamer, while a construct including the ectodomain forms a dimer. Under certain conditions, the pentamers cluster together, forming supramolecular assemblies that may have a unique role in the virus life cycle. New sensitivity-enhanced …
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The effect of vanadium oxidation states on the conversion of hydrogen sulphide to elemental sulphur
… in this study were the dimer, tetramer, and pentamer. V⁵⁺ ions in the solutions were qualified by ⁵¹V NMR using the NMR literature data to predict dimer, tetramer, and pentamer in these solutions. A thermodynamic model was developed using the OLI studio analyzer. This model showed that V⁵⁺ is …
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The role of subunit interfaces in the function of nicotinic acetylcholine receptor
… can be introduced in defined subunits of the pentamer. The overall aim of this PhD study was to advance our understanding of how the signature β2/β2 and α4/α4 interfaces of (α4β2)2β2 and (α4β2)2α4 nAChRs respectively affect the function of neighbouring α4β2 nAChRs. In (α4β2)2α4 receptors, the …
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Induktion von Sekundärstrukturen durch den Einbau von Alanyl-PNA in Peptide und Proteine
… 20 mit eingebautem Alanyl-PNA-Pentamer dargestellt. Es konnte mittels temperaturabhängiger UV-Spektroskopie gezeigt werden, dass sich bei Zugabe des komplementären Gegenstranges nichtkovalente Duplexe bilden. CD-spektroskopische Untersuchungen dieses Dimers lieferten keine …
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Phase Phenomena of Proteins in Living Matter
… prevalent as one proceeds from monomer to pentamer, with extended inter-domain beta sheets appearing first, then multi-sheet `intramolecular amyloid' structures, and finally novel motifs containing alpha helices. Finally, in developing principles of protein behavior \emph{in vivo}, we …
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The role of subunit interfaces in the function of (α4β2)2β2 nAChRs
Nicotinic acetylcholine receptors (nAChRs) are pentameric ligand-gated ion channels formed from homologous subunits, of which there are many different subtypes. The ability to combine different types of subunits into an individual pentamer enables a wide diversity of functional properties to meet a …
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Understanding the Structure-Property Relationship in Diketopyrrolopyrroles for Organic Electronics
… the chain length increased from the dimer to the pentamer, the value largely decreased, suggesting that a saturation limit had been reached. On the other hand, this was challenged by the polymer’s largely red-shifted absorption compared to any other compound in the study. However, as the expected …
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Discovery and dissemination of new knowledge in food science: Analytical methods for quantification of polyphenols and amino acids in fruits and the use of mobile phone-based instructional technology in food science education
… compounds (catechin, epicatechin, PC B2, PC pentamer, chlorogenic acid, phloretin, and quercetin) to the polyphenol and flavanol quantification results using Prussian blue (P-B), F-C, DMAC and BSA precipitation methods were also assessed and determined to differ by up to thirteen-fold, …
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Architecture and assembly of maize streak virus: insights from 3D electron microscopy
… modelling of the MSV CP was undertaken using the pentamer (CPs) of Satellite tobacco necrosis virus (STNV) as a structural template. Correlation-based fitting of icosahedral and geminate atomic models that varied in geometric arrangement of MSV CPs allowed the geometric parameters of the bipartite …
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