Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"Penetration enhancers"”.
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QSAR modeling of chemical penetration enhancers using novel replacement algorithms
… are suitable to cross the skin barrier. Chemical Penetration Enhancers (CPEs) are used to promote the absorption of solutes across the dermal layers. In this investigation, a Quantitative Structure-Activity Relationship (QSAR) model is applied to relate chemical penetration enhancer structures …
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Chemical penetration enhancers and in situ-forming reservoirs for trans-tympanic drug delivery : progress toward improved treatment of Otitis media
… that includes potentially synergistic chemical penetration enhancer (CPE) combinations and an antimicrobial sufficiently increases antimicrobial flux such that therapeutic levels can traverse the tympanic membrane (TM) within 12 hours, in vitro. We compare excised chinchilla TMs treated with …
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An investigation of some factors affecting transdermal permeation.
… Differential Thermal Anlaysis (DTA) and in vitro penetration studies of neonatal rat stratum corneum (s.c.), with radiolabelled propanol and hexanol as penetrants. Thermogravimetric Analysis, Thin-Layer Chromatography (TLC) and Infrared Spectroscopy were used to provide additional information. DTA …
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An investigation of the effect of surfactants on transdermal permeation.
… mechanisms of action for these compounds as penetration enhancers. The main methods used in the study were: determination of the permeability of neonatal rat stratum corneum to propan-2-ol; differential scanning calorimetry (DSC); Fourier transform infrared spectroscopy (FTIR); and thin layer …
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Investigation of membrane permeation using ATR-FTIR spectroscopic imaging and multivariate target factor analysis
… mechanisms of drug permeation and the effects of penetration enhancers on silicone membrane and human stratum corneum (SC). Simulated spectroscopic imaging data sets were used to validate the scope and application of quantitative iterative target transformation factor analysis (QITTFA) which is a …
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Effect of formulation factors on the skin penetration of drugs
… formulated in mixtures containing various penetration enhancers, models were developed that could unravel the connection between structural features of such mixture ingredients and the skin permeation of the permeants. This work was further developed by investigating the combined effect of …
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Biopharmaceutical approaches for improved drug delivery across ocular barriers
… pigmented epithelium (RPE P-gp) limits the penetration of substrates, in therapeutically relevant concentrations, into the back-of-the-eye. </p> <p>In the present research, use of penetration enhancers (chitosan, benzalkonium chloride (BAK) and ethylenediaminetetraacetic acid (EDTA)) and …
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Formulation and preparation of niosomes containing bioactive compounds
… oleic acid (OA) and linoleic acid (LA) as penetration enhancers. The EIM method allowed obtaining niosomes with smaller mean size, narrower size distribution and higher EE values than those provided by the TFH-S method.
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Topical Formulation For Stimulating Sweat Secretion as an Alternative to Iontophoresis
… each at varying concentrations were screened as penetration enhancers. In vitro penetration test (IVPT) was performed on these formulations to compare the influence of these ingredients on the penetration of pilocarpine. The results from the preliminary studies indicate that the formulation with …
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Role of cavitation, surfactants, and their synergism in transdermal sonophoresis
… that causes synergism between LFS and chemical penetration enhancers (CPEs), iii) the interactions between traditional and non-traditional surfactants in LFS skin treatments, and iv) the effects of LFS and LFS/CPEs on skin structural perturbation. In the first study of this thesis, the intrinsic …
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Nanostructures for protection and vehiculation of bioactive molecules
… high biocompatibility, can be regarded as strong penetration enhancers. They are combined to rapidly formulate (15 min) a cationic liposome nanostructure endowed of excellent stability ( > 6 months) and skin penetration ability, along with low short-term cytotoxicity, as evaluated via the MTT …