Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"Peg3"”.
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DNA methylation analysis and identification of a novel antisense transcript in the Peg3 imprinted domain
… often regulated in clusters, one of which is the Peg3 (Paternally expressed gene 3) imprinted domain. We investigated this region for both CpG islands and long antisense transcripts, two common features of imprinted gene clusters. First, we performed a systematic survey of DNA methylation status …
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Role of Xenopus p21-activated kinase 2 (X-PAK2) in polar body formation during oocyte maturation
… de novo synthesis of a protein kinase termed pEg3. Prophase oocytes contain low levels of pEg3 protein. De novo synthesis of pEg3 protein is evident during oocyte maturation. (Abstract shortened by UMI.)
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Targeting an E3 ubiquitin ligase Siah1 and a cysteine protease SENP1 using SPR and DSF-based fragment screening
… species. Siah1 was reported to collaborate with PEG3 in the regulation of ß-catenin degradation. A SCAN domain, located at the N-terminus of PEG3, was tested for binding using gel filtration chromatography and NMR, but no interaction was observed. PEG3 was used in the crystallographic studies and …
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Hydrodynamic behavior and thermal stability of a PEGylated protein: Studies with hen egg lysozyme
… (PEG1-HEL), di (PEG2-HEL), and triPEGylated (PEG3-HEL) species.</p><p>The hydrodynamic properties of HEL were altered upon PEGylation. A decrease in sedimentation (s) and diffusion (D) coefficients was observed for all three PEG-HEL molecules in comparison to HEL (1.81 s). Despite differences …
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Epigenetic Response to Low-Dose Ionizing Radiation
… technology. Second, three imprinted genes, Peg3, Nnat, and H19, were assessed for methylation changes in differentially methylated regions (DMRs) that regulate their parent-of-origin monoallelic expression using Sequenom technology. Lastly, it was postulated that the epigenetic changes at …
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Reductions in expression of growth regulating genes are observed in skeletal muscle and organs with age
… regulating genes (Ezh2, Gpc3, Mdk, Mest, Mycn, Peg3, and Plagl1) in male and female skeletal muscle, heart, and liver with age. It was hypothesized that the expression of these genes would differ not only between sexes, but also between tissues. Female and male C57BL/6J mice were sacrificed at …
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Determination of p53 role in cancer biology and therapy through interactome development and analysis
… efficacy in sarcomatoid, and CYP24A1, HIPK4 and PEG3 in biphasic p53 (+/+) malignant mesothelioma tumours. Drug profile analysis of deregulated genes identified by the model highlight the need for individualised therapeutic approaches, and we offer putative combined targeted therapeutic …
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The Effects of Cannabis sativa on the Sperm Epigenome
… spermatid-like cells at Paternally Expressed 3 (PEG3) and Growth Factor Receptor-Bound Protein 10 (GRB10). Next, methylation was assessed at a group of genes randomly chosen genes from the Simons Foundation Autism Research Initiative (SFARI) autism candidate gene list, half of which possessed …