Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 52 for “"Pedigrees"”.
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Problems in Pedigrees and Phylogenies
The footprint of genetic inheritance can be observed among both familial relationships between individuals and evolutionary relationships between species. The former can be depicted by a pedigree, whereas the latter can be depicted by a phylogeny. These two distinct objects can be viewed as …
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Improving Record Linkage Through Pedigrees
Record linkage, in a genealogical context, is the process of identifying individuals from multiple sources which refer to the same real-world entity. Current solutions focus on the individuals in question and on complex rules developed by human experts. Genealogical databases are highly-structured …
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Estimation of Variance Components in Finite Polygenic Models and Complex Pedigrees
… of dominance variance for large, complex pedigrees containing inbreeding, whereas the IM suffers severe limitations under inbreeding. Inclusion of dominance effects into the genetic evaluations of livestock, with the potential increase in accuracy of additive breeding values and added …
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Genetics Analysis of Bone Size Variation of Hip, Spine and Wrist in Human Pedigrees
… (DXA). For 635 individuals from 48 human pedigrees, 204 markers from chromosome 9 to chromosome X were genotyped that define a ~10 cM resolution human index map. Adjusting for age, sex and weight as covariates, I performed variance component analysis of bone sizes as quantitative traits …
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Valutazione del rischio genetico di comportamento suicidario nel disturbo bipolare: analisi di 737 pedigrees
Suicide is a significant cause of mortality in patients with major affective disorders(MAD). Suicidal acts are typically more lethal in MAD. A large contribution to the suicide risk derives from the presence of family history of suicidal behavior. Other clinical factors, such as treatment with …
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Parentage analysis in a free-ranging, closed population of southern white rhinoceros : genetics, pedigrees and management
Small populations of animals are vulnerable to the consequences of breeding within a closed group – inbreeding depression and genetic drift lead to reductions in genetic variability, which in turn can give rise to the amplification of deleterious traits. Traditionally, managers attempt to minimise …
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Using DNA markers to trace pedigrees and population substructure and identify associations between major histocompatibility regions and disease resistance in rainbow trout (Oncorhynchus mykiss)
Examination of variation at polymorphic microsatellite loci is a widely accepted method for determining parentage and examining genetic diversity within rainbow trout (Oncorhynchus mykiss) breeding programs. Genotyping costs are considerable; therefore, we developed a single-step method of …
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Interactive pedigree plotter for genetic analysis
… method to analyze these rare variants is to use pedigrees, but because of the low penetrance of these variants, the researcher may have to draw very large pedigrees, hundreds or even thousands of individuals, just to understand the inheritance of the variant. This thesis reviews a pedigree …
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Cancer Incidence In First and Second Degree Relatives of Brca1 and Brca2 Mutation Carriers
… to the general population. A total of 1086 pedigrees of <em>BRCA</em> mutation carriers were obtained from a prospectively maintained, internal review board approved study of persons referred for clinical genetic counseling at The University of Texas MD Anderson Cancer Center. We identified …
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The molecular genetics of Type 2 diabetes
… the role of the glucokinase gene in five pedigrees with maturity onset diabetes of the young (MOOY). Using the microsatellite polymorph isms GCK1 and GCK2, diabetes was found not to be linked to the glucokinase gene in these multi-generation pedigrees. <br></br><br></br> Chapter 4 assesses …
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Towards identifying the ADRP gene in a large South African family with retinitis pigmentosa
… British origin. The family is one of the largest pedigrees from which DNA is archived in the Department, and the pedigree structure and ADRP phenotype will be discussed in detail in chapter two.
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An Integrated Software System for EEG/EMG-Based Forward Genetic Screen of Sleep/Wake Abnormalities in ENU-Mutagenized Mice
… mice, and established >10 heritable phenodeviant pedigrees, including one exhibiting markedly increased NREM sleep amounts, and one with reduced episode durations and amounts of REM sleep. The causal mutations for these two pedigrees have been positionally cloned through the whole-exome sequencing …
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Genetic Evaluation and Parameter Estimation Using Marker and Trait Information
… part. The approximation is efficient for large pedigrees with complex loops in terms of computing speed and memory requirements.
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Why do allelic variants of the mitochondrial chaperone SCO1 cause clinically heterogeneous forms of disease? A mouse model and proximity ligation study
… the clinical heterogeneity observed across SCO1 pedigrees. My SCO1 interactome studies identified several interesting candidate partners whose interactions may be perturbed by pathogenic SCO1 variants and contribute to tissue-specific clinical phenotypes. I prioritized characterizing the …
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Inheritance and incidence of atresia coli in Holstein cattle
… University of Illinois Holstein herd occurred in pedigrees of atresia coli calves born in other Holstein herds in Illinois. A progenitor of atresia coli calves born in the University of Illinois Holstein herd was also present in pedigrees of several affected calves born in the Holstein herd of …
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Occurrence, etiology and management of ringwomb in ewes
Pedigrees of ewes with Ringwomb were studied to determine the etiology, incidence and treatment of Ringwomb. Purebred Suffolk and crossbred Hampshire and Shropshire ewes aged from one to seven years were observed over a period of five lambing seasons. The study was conducted on 24 clinical cases of …
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The Genetics of Type 2 Diabetic End-Stage Renal Disease in African Americans
… diabetes diagnosis (maximized LOD = 3.72; 64% of pedigrees). This region had been previously linked to diabetic nephropathy in other populations. To identify genes which contribute to T2DM-ESRD in African Americans on chromosome 18q21.1-23, candidate gene analysis, fine mapping, and dense SNP …
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Mapping Genes for Complex Traits: Obesity, Diabetes, Hypertension, and Dyslipidemia on the Pacific Island of Kosrae
… with covariate corrections in large extended pedigrees with multipoint analysis. This is virtually impossible to do with the current linkage programs, due to the computation difficulties of exactly calculating every possibility. Instead, sampling methods that sample the most likely data …
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Avaliação genética da produção de leite no dia do controle de caprinos de aptidão leiteira utilizando modelos de regressão aleatória multicaracterísticos
… a aplicação do software de recodificação de pedigrees alfanuméricos RENPED; verificar diferentes alternativas nas estruturas de ponto de truncamento, efeitos fixos e unidades de medidas da variável resposta produção de leite no dia do controle sobre a classificação dos animais avaliados …
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Great individuals of the Guernsey breed
… families of linebred stock. 9. A study of the pedigrees of great sires, or the Guernsey breed, strengthens the conclusion reached in summary point 8.
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