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Showing 1 to 11 of 11 for “"Pediatric acute lymphoblastic leukemia"”.
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Genetic Polymorphisms and the Treatment Outcome in Standard-Risk Pediatric Acute Lymphoblastic Leukemia
<p>Acute lymphoblastic leukemia (ALL) is the most common childhood cancer and accounts for 30 - 35% of all cancers in children. Significant improvement in the treatment of pediatric ALL has been achieved in recent years. Only 50 years ago, the disease was uniformly fatal with an Overall Survival …
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Visual Working Memory and Visual Selective Attention among Survivors of Pediatric Acute Lymphoblastic Leukemia (ALL)
… and visual selective attention in survivors of pediatric acute lymphoblastic leukemia (ALL) either at high-risk or low-risk for neurocognitive impairments based on their treatment regimen and non-cancer controls. Previous investigations of neurocognitive impairments in survivors of pediatric ALL …
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Congruence of Parent-Report, Self-Report, and Performance-Based Neuropsychological Functioning in Pediatric Acute Lymphoblastic Leukemia Survivors
Acute Lymphoblastic Leukemia (ALL) is thought to have long-term cognitive effects, and clinicians often rely on parent report to screen for cognitive impairment during survivorship, despite limited congruence with neuropsychological performance and susceptibility to parental factors such as stress. …
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Somatic Mutation Detection in Leukemia-Derived Circulating DNA: Utility in Monitoring Clonal Dynamics and Disease Response in Pediatric Acute Lymphoblastic Leukemia
… associated with current treatment strategies ofpediatric acute lymphoblastic leukemia (ALL), relapse still represents a major challenge. Pediatric ALL demonstrates branched evolution in response to selective pressure exerted by therapy; relapse founder clones emerge from pre-leukemic clones or …
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Culturally Informed Motivational Interviewing to Improve Oral Chemotherapy Adherence for Pediatric Acute Lymphoblastic Leukemia Patients and Their Caregivers: A Feasibility, Acceptability, and Preliminary Efficacy Trial
BACKGROUND: Curative therapy for childhood acute lymphoblastic leukemia (ALL) mandates a two-to-three-year maintenance chemotherapy phase wherein patients must take daily oral 6-mercaptopurine (6-MP). 6-MP regimen adherence is challenging and failure to take medication has been associated with an …
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Impact of Childhood Acute Lymphoblastic Leukemia and its Treatment on Social-Emotional, Intellectual, and Academic Abilities
… resulting from the diagnosis and treatment of pediatric acute lymphoblastic leukemia (ALL) been the subject of empirical investigations for approximately 25 years, with an emphasis on those patients treated with radiation therapy. In more recent years, however, research has shown that children …
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The Role of Nutrient Availability in Therapeutic Response of Leukemia
… under ASNase treatment. In glutamine-anaplerotic leukemia cells, we found that TPP availability enables asparagine synthesis from extracellular glutamine. Mechanistically, TPP is critical for the activity of alpha-ketoglutarate dehydrogenase (AKGDH), a TCA cycle enzyme that catalyzes a step in the …
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IKAROS and LEUKEMIA
Acute lymphoblastic leukemia (ALL) is characterized by an accumulation of immature lymphoid cells in the bone marrow and is the most common cancer type in children. It is an immunophenotypically, morphologically, clinically, and genetically heterogeneous disorder that comprises several distinct …