Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"Pediatric High Grade Gliomas"”.
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Targeting Unique Domains of Lsd1 Regulates Pediatric Glioma Innate Immunity and Nk Cell Metabolism
… may aid new modalities such as immunotherapy. Pediatric high-grade gliomas (pHGGs) often possess mutations in histone coding genes that cause aberrant histone methylation and gene expression. Cells derived from these patient’s tumors display growth inhibitory sensitivity to epigenetic drugs …
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Novel Oncogenic Drivers in Pediatric Gliomagenesis
<p>Pediatric high-grade gliomas (pHGGs), with a two-year survival rate of less than 20%, are some of the most aggressive human cancers. This dissertation begins with our analysis of 127 pHGGs, including brainstem (BS) and non-brainstem (NBS) tumors, from 118 patients using next-generation …
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Pharmacological Inhibition of LSD1/KDM1A in Diffuse Midline Glioma Models and Impact on Kinase Signaling
<p>Diffuse Midline Gliomas (DMG) occur in the midline structures of the brain such as the brainstem. DMG, a subset of pediatric high-grade gliomas (pHGGs), confers poor prognosis in children with survival rates below two years post-diagnosis. This is heavily due to limited treatment options as …