Global ETD Search
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Showing 1 to 13 of 13 for “"Peak capacity"”.
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MICROFLUIDIC DYNAMIC ISOELECTRIC FOCUSING COUPLED TO MATRIX ASSISTED LASER DESORPTION/IONIZATION MASS SPECTROMETRY
… separating and detecting many different sample peaks. The complexity of such samples indicates that a single separation method will not be able to provide the needed resolution. If two methods that are orthogonal are combined, then the peak capacity of the combined system is the product of the …
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Synthesis and Characterisation of Electron Conducting Mesoporous ti and ta Oxide for Use as Potential Electrode Materials in Lithium Ion Batteries
… Pristine mesoporous titanium oxide produced a peak capacity of 301 mAh/g at current densities of 0.2 mA.cm-2 and 187 mAh/g at 1 mA.cm-2. The conductivity of the composite improved from 3.56 x 10-2 mS.cm-1 to 5.79 mS.cm-1 but significantly reduced capacity. This was attributed to pore blocking …
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Protein LC-MS Using Slip Flow Chromatography
… of a complex mixture of protein digests. A peak capacity of 500 was achieved by using a 30 min gradient elution. Other bonded phases such as C4 and TDP were also developed to separate different protein samples. This dissertation also includes 1) separation of intact monoclonal antibodies by …
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Development of Polymer Monoliths for the Analysis of Peptides and Proteins
… using a simple salt gradient. Extremely narrow peaks were obtained for the analysis of synthetic peptides, natural peptides and a protein digest. A peak capacity of 179 was achieved. Although the poly(AMPS) monolith demonstrated extraordinary performance, one main drawback of this monolith was …
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ELECTROKINETIC SEPARATIONS ON MICROFLUIDIC DEVICES FOR N-GLYCAN PROFILING
… prognosis. To further increase the separation peak capacity, microfluidic platforms with serial-to-parallel interfaces were evaluated for two-dimensional N-glycan profiling. Three designs and operation modes were investigated, and an interface with a gated valve provided the highest performance …
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High performance liquid chromatography-tandem mass spectrometry of pharmaceuticals and personal care products in environmental and biological matrices
… promising results. Investigations into loading capacity and peak capacity of the half-metre monolith also highlighted the suitability of the long monolith for the screening of large numbers of pharmaceutical compounds. The half-metre monolithic column was applied to the analysis of …
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Two-Dimensional and High-Throughput Electrophoretic Separation of Proteins Using Polymeric Microchips
… due to the minimal dead volumes produced during peak transfer between the two separation dimensions. In addition, fast separations can be envisioned because the column lengths are typically shorter in microfluidic platforms without scarifying peak capacity. High-throughput capabilities are …
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Analysis of the volatile organic compounds produced by the decomposition of pig carcasses and human remains
… spectrometry (TD-GCxGC-TOFMS). The additional peak capacity and spectral deconvolution of the GCxGC-TOFMS system generated a characteristic profile of decomposition VOCs across the various stages of soft tissue decomposition. The profile was comprised of numerous chemical families, particularly …
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Synthesis and Characterization of Polymer Composite Materials For Lithium Battery Cathodes and Capacitors
… lower initial voltage drop, higher discharge capacity and higher rate-capability than state-of-the-art SVO. PPy/SVO composite cathode materials were synthesized by polymerizing pyrrole onto the surface of pure SVO particles. Electrochemical characterization was carried out by performing …
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Development of Methods for the Study of Phosphoproteins
… several favorable features, such as high binding capacity, extraordinarily high resolution, and high peak capacity, making it ideal for resolving complex peptide samples. Application of this novel column to isolate model phosphopeptides was shown. More general use of this column in MudPIT (strong …
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The Investigation and Application of Alternative Strategies for LC/MS based Bioanalytical Research
… utilizing a diverse mix of compounds yielded a peak capacity of 55 as the average peak widths for all analytes was 0.11 minutes for a 6 minute separation. Resolution of the probe pharmaceutical alprazolam and associated hydroxylated metabolite was maintained between 1.2 and 1.5 for four …
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Genome-scale Precision Proteomics Identifies Cancer Signaling Networks and Therapeutic Vulnerabilities
… MS. The column was capable of achieving a peak capacity of approximately 700 in a 720 min gradient of 10-45% acetonitrile. The optimal loading amount was about 6 micrograms of peptides, although the column allowed loading as many as 20 micrograms. Gas phase fractionation of peptide ions …
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Vícerozměrné separace v kapalné fázi
Dizertační práce se zabývá problematikou vícerozměrných separací v kapalné fázi. Tyto separační techniky jsou vyvíjeny ve snaze splnit současné požadavky kladené na analýzu velmi složitých vzorků, jejichž komponenty jsou teplotně nestálé, mají nízkou tenzi par nebo vysokou molekulovou hmotnost a …