Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 24 for “"Pax3"”.
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Pax3 expression in cutaneous malignant melanoma
… investigated the repercussions of aberrant PAX3 re-expression in cutaneous malignant melanoma (CMM). The transcription, factor encoded by PAX is amongst the first expressed in the embryo, with a principal role in the development of the melanocytic lineage. We theorised that abnormal …
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New perspectives on melanoma: The role of PAX3
… cutaneous melanocytes. The transcription factor PAX3 is critical for the proper development of neural crest lineages including melanocytes. Melanocytic cells show continued PAX3 expression from melanoblast formation in the neural crest to their differentiation into melanocytes. While many studies …
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The characterisation of Pax3 expressant cells in adult peripheral nerve
Pax3 has numerous integral functions in embryonic tissue morphogenesis while knowledge of its complex function in cells of adult tissue continues to unfold. Across a variety of adult tissue lineages, the role of Pax3 is principally linked to maintenance of the tissue’s resident stem and progenitor …
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PAX3 expression, protein modifications and downstream target gene profiling in melanocytes and melanoma cells
PAX3 is a transcription factor. It plays a major role in the development of melanocytes in the embryo. As a result of alternative splicing, the gene gives rise to eight different transcripts which encode proteins that have differing structures and are therefore likely to activate different …
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The role of PAX3/PAX7-FKHR in mesenchymal stem cell myogenic differentiation and rhabdomyosarcomagenesis
… t(2;13) or t(1;13) translocations, involving PAX3-FKHR and PAX7-FKHR fusion genes respectively. These genetic events result in a molecular gain of function of the fusion protein, which is proposed to perturb the differentiation of muscle progenitor cells. Since PAX3/7-FKHR fusions result in …
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The Role of Pax3 in Neuronal Differentiation of the Ophthalmic (OpV) Trigeminal Placode and Neural Tube during Chicken Embryonic Development
Pax3 has been used as a valuable marker in research aimed at understanding tissue interactions involved in trigeminal ophthalmic (opV) placode development. While Pax3 expression coincides with opV neuron specification, the function of Pax3 in these cells has not previously been investigated. …
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Pax3 expression in satellite cells of avian skeletal muscle spindles during normal development and with experimental muscle overload
Pax3 protein is initially expressed in the dermomyotome of embryonic somites, which gives rise to skeletal muscle. Following myogenesis, Pax3 expression is mostly down-regulated and becomes restricted to a few satellite cells (SCs) of select mature muscles. SCs are activated to form new myonuclei …
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The role of pax genes in vertebrate segmentation
… a range of processes in the developing embryo. Pax3 and Pax7 in particular are associated with the paraxial mesoderm, especially the development of the myogenic lineage. However, recent studies have suggested that Pax3 and Pax7 may have earlier, morphogenetic roles in the segementation of the …
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Strukturelle und funktionelle Untersuchung der Promotorregionen der menschlichen PAX3-, PAX6- und PAX7-Gene: Bedeutung von Polymorphismen für schizophrene Erkrankungen
… wurden die Promotorregionen der menschlichen PAX3-, PAX6- und PAX7-Gene charakterisiert. Weiterhin wurden funktionelle Folgen der mit diesen Promotoren assoziierten Repeat-Polymorphismen auf die Expression dieser Gene untersucht. Schliesslich wurde die Relevanz für die psychischen Erkrankungen …
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Direct Reprogramming Of Fibroblasts Into Muscle Or Neural Lineages By Using Single Transcription Factor With Or Without Myod Transactivation Domain
… transcription factor involved in myogenesis (Pax3) or neurogenesis (NeuroD1) alone can directly reprogram the mouse embryonic fibroblasts (MEFs) into myogenic or neurogenic lineages, respectively. In addition, we created fusion transcription factors (Pax3 or NeuroD1) with the potent MyoD …
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The role of <em>Pax7</em> in the formation of the superior colliculus and the vertebrate visual system
… superior collicular polarity. The paralogue Pax3 is thought responsible for sustaining embryonic development in Pax7 mutant mice, resulting in a less severe phenotype. Therefore, this project explored temporospatial patterns of Pax3 expression relative to Pax7 expression during all embryonic …
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TBX2 IS INVOLVED IN MYOGENESIS AND ITS DEREGULATION PROMOTES TUMORIGENESIS IN RHABDOMYOSARCOMA
… of FGF-2. RMS cells constitutively express PAX3 and PAX7 which are expressed and function in myogenic precursors, but are quickly degraded in myoblasts and during myogenesis. We found that TBX2 was a downstream target of PAX3 in RMS cells, as well as the ARMS specific fusion proteins …
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An investigation of the mechanism of PAX7 mediated oncogenesis via in silico and in vitro biology
… Some members of the Pax family, which includes Pax3 and Pax7, encode a second DNA binding domain of the paired-type homeodomain (HD) class. Pax3 and Pax7 are closely related paired box family members specifically expressed in the dorsal neural tube and the developing somites and in proliferating …
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Integrins in muscle disease and repair
… knockout (cKO) mice using HSA-Cre and Pax3-Cre promoter systems. Our findings show no obvious difference in the Itga5 cKO when the HSA promoter drives Cre recombinase, however conditional loss under the control of the Pax3 promoter leads perinatal lethality. In addition we investigate …
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FROM A PLACODE PROGENITOR PLATFORM TO A TRIGEMINAL GANGLION ORGANOID: MODELLING SENSORY DEVELOPMENT AND FUNCTION IN VITRO
… a trigeminal fate, marked by the expression of PAX3, and thus develops into the TG. The TG is involved in several human pathologies, such as migraine and viral diseases, including the establishment of viral latency in trigeminal sensory neurons by herpesviruses. TG-associated pathologies remain …
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High-Resolution Array Comparative Genomic Hybridization Identifies Common Targets in Rhabdomyosarcoma
… cases, is characterized by the presence of the PAX3/7:FOXO1A translocation. ERMS is associated with a younger age at presentation, sites of disease other than the extremities, a more favorable clinical outcome, and the absence of consistent chromosomal translocations. Here we used high-density …
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Regulation of melanogenesis in conditionally immortalised mouse melanocytes expressing a temperature-sensitive SV40 large T antigen
… revealed that there were no detectable levels of Pax3 transcripts at either temperature. In addition, Pax3 expression was absent in the highly pigmented DMEL-2 and melan-a cell lines. These results suggest that Pax3 is not required for mi expression and that it is unlikely to be a target of the T …
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Developmental dynamics of posterior segment addition in the spider Parasteatoda tepidariorum
… against Pt-Cad and Pt-Wnt8, and tested a Pax3/7 antibody from Davis and Patel, which recognises Prd protein across arthropods. The Pt-Cad antibody detected Pt-Cad protein in the SAZ at stage 6, but signal intensity was insufficient for extended analysis. The anti–Pt-Wnt8 antibody did not …
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Development of the Inner Ear: a Molecular, Cellular and Evolutionary Approach to Understanding the Development of the Inner Ear with an Emphasis on the Roles of Fgf10 and Foxgl
… and Six1), Waardenburg’s (mutations occur in the Pax3 and MITF genes, among others), Pendred's (caused by a mutation in the PDS /pendrin gene) and Usher’s (caused by a mutation in one of several USH genes) Syndromes. In addition, over 70 different genes have been described that produce …
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