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Showing 1 to 12 of 12 for “"Pauson-Khand"”.
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Expansion of the scope of the allenic Pauson-Khand reaction to include carboxylic acids and esters
… could be prepared to test the viability of the Pauson-Khand reaction in the presence of these functional groups. The positioning of the groups also lead to variations in the system. These reactions produced three different types of adducts. They include alpha-methylene cyclopentenones, …
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Synthesis of P-Stereogenic Bisphosphine Ligands: Application as Hemi-labile Ligands in the Asymmetric Pauson-Khand Reaction
… of their use in a Co-catalysed asymmetric Pauson-Khand reaction has been carried out. The ligands were synthesised by asymmetric lithiation of a phosphine sulfide or a phosphine borane using alkyllithium/()-sparteine complexes, trapping with Ph2PCl or t-Bu2PCl and treatment with BH3•Me2S …
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Coordination Chemistry of Bis(diphenylphosphino)amine Ligands with Cobalt Carbonyl and the Intermolecular Catalyzed Pauson-Khand Reaction
… 2, the compounds show activity for the catalytic Pauson-Khand reaction, whereas when the PNP ligand bridges, as in 3, the reaction precedes stiochiometrically. The use of these chiral ligands has not yet resulted in enantioselective catalytic Pauson-Khand cycloadditions. However, a small 15% e.e. …
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Applications of titanium-mediated reductive coupling and cyclocarbonylation reactions toward natural product synthesis
… and methyl jasmonate. Based on this hetero Pauson-Khand strategy, we have established an efficient racemic route to both the prostaglandin and the methyl jasmonate core skeletons. Moderate to excellent selectivities with regard to the hetero Pauson-Khand reaction were observed in both cases. …
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Transition-metal catalysis of cyclocarbonylation and cycloisomerization reactions
Chapter 1. The asymmetric Pauson-Khand cyclization of nitrogen-containing enynes using carbon monoxide and a catalytic amount of (EBTHI)TiMe2 was examined. The influence of the nitrogen substituent and the concentration of the catalyst on the enantioselectivity of this cyclization was explored. It …
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Enantioselective Syntheses and Chemical Investigations of Plant-Derived Bioactive Volatile Compounds
… epsilon-unsaturated carbonyl compounds, hetero Pauson-Khand substrates, via [3,3]-sigmatropic rearrangements.
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Organocobalt Mediated Cyclizations and Biochemically Inspired Isomerizations - Method Development and Mechanistic Studies.
… literature from the early to mid-2010s of the Pauson-Khand Reaction(PKR). Chapter two focuses on our work utilizing x-ray absorption spectroscopy(XAS) to characterize reaction in- termediates of the intermolecular PKR. Chapter three highlights our group's work developing the use of N 2 O as a …
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Auxiliares quirales derivados de carbohidratos: Nuevas aplicaciones
… of glyceraldehyde as chiral auxiliaries in Pauson-Khand and Staudinger reactions, along with the synthesis of cyanohydrins, processes where the use of carbohydrates as chiral auxiliaries has been scarcely explored. Thus, the featured results constitute original solutions and a new concept of …
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Towards the total synthesis of Agariblazeispirol C
… Heck reaction and an intramolecular Pauson-Khand cyclisation. With regards to the construction of the main core of the molecule, the synthesis of a late stage intermediate has been accomplished. Various new strategies towards the completion of the synthesis have been devised and work …
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Synthetic Studies Of Biologically Active Molecules: Irl 2500, Bruceantin, And Biliatresone
… bruceantin, we proposed to develop a homologous Pauson Khand reaction utilizing a strained bicyclic compound to generate bridged cyclohexenones via a [3+2+1] cycloaddition as a possible method to generate the bruceantin ring system. The synthesis of suitable bicyclic substrates for this reaction …
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Unique approaches towards the synthesis of polycyclic sesquiterpene targets
… the key tricyclic core of sesquithuriferone, a Pauson-Khand approach was pursued. In this regard, a wide range of structural derivatives were synthesised and examined, under a spectrum of standard protocols, to identify an optimal structure to facilitate this key organometallic annulation. Upon …
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A synthetic and computational approach to the design of new photoactive organometallic materials.
… complexes formed by a photochemically induced Pauson-Khand reaction. Matrix isolation sample preparation and matrix isolation studies for (n6-phenanthrene)Cr(CO)a~re also discussed.