Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 2 of 2 for “"Patz1"”.
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Master regulators of neuronal maturation in NGN2 reprogrammed iPSC-derived iNeurons
… the transcription factors CUX2, ZNF384, FOSL2, PATZ1 and ONECUT2 for further in-depth investigation. MEA analysis demonstrated notable impairments in iNeuron electrophysiology, while neurite and synaptic connectivity profiling revealed stunted neurite outgrowth and synapse maturation, …
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CRISPR activation screening at single-cell transcriptomic resolution: discovering new regulators of zygotic genome activation
… remodeller Smarca5 and the transcription factor Patz1. I subsequently validate these top hits using both CRISPRa and cDNA overexpression in mESCs. By doing this, I uncover new factors that promote a ZGA-like response in mESCs and are, therefore, strong candidates for ZGA regulation in vivo. …