Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 75 for “"Pattern recognition receptors"”.
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Pattern Recognition Receptors & Dendritic Cell Function in health and disease.
Contains fulltext : 71516.pdf (Publisher’s version ) (Open Access)
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Elucidating the Role of Pattern Recognition Receptors in Understanding, Treating, and Targeting Cancer
Pattern Recognition Receptors (PRRs) are a group of evolutionarily conserved and germline-encoded cellular receptors of the innate immune system that are responsible for recognizing and responding to the entirety of the pathogens a host encounters. The ingenuity of the innate immune system is that …
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Clinical approaches for understanding the expression levels of pattern recognition receptors in otitis media with effusion
… we evaluated the expression levels of Toll-like receptors (TLRs) -2, -4, -5, -9, and nucleotidebinding oligomerization domain-containing proteins (NODs) -1 and -2, all of which are related to bacterial infection in pediatric patients with otitis media with effusion (OME). METHODS: The study …
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Investigation of mechanisms underpinning host-microbial interactions in the gastrointestinal tract
… the relative contributions of different pattern recognition receptors to the triggering of macrophage cytokine responses by the widely studied Gram-positive commensal bacteria Lactobacillus salivarius and Bifidobacterium breve. L. salivarius induced macrophage cytokine responses that were …
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Key Role of Lys63-Linked Polyubiquitination in Viral Activation of IRF3
… are detected by mammalian cells through receptors belonging to pattern-recognition receptors family (PRRs). Among PRRs, RIG-I-like receptors (RLRs), including RIG-I, MDA5 and LGP2, are responsible for sensing intracellular viral RNAs. MAVS, a mitochondria-localized transmembrane protein, …
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Optimization of an Immune Assay to Detect Binding of NOD2 to Staphylococcus Aureus
… by which <em>S. aureus</em> avoids detection by Pattern Recognition Receptors (PRRs), such as Nuclear Oligomerization Domain 2 (NOD2), present on the surface of and inside innate immune cells. This study aimed to design and optimize an assay that can be utilized to investigate <em>S. aureus</em> …
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Regulation of receptor kinase-mediated immune signalling by dynamic phosphorylation
Plants recognize pathogen-associated molecular patterns (PAMPs) via cell surface-localized pattern recognition receptors (PRRs), initiating a broad-spectrum defense response against pathogens, known as PRR-triggered immunity (PTI). However, immunity comes at a cost; and immune responses need to be …
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Characterizing the function of human toll-like receptor 10
Toll-like Receptors (TLRs) are important constituents of the immune response, capable of both protecting the host from danger and inciting harm from within. In this Thesis, I present evidence that the last human orphan toll-like receptor, TLR10, has a unique function that differs from its other …
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Characterization of pattern recognition receptor responses against materials for cell encapsulation
… cells. These macrophages may sense alginate via pattern recognition receptors (PRRs), such as toll-like receptors (TLRs) and NOD-like receptors (NLRs). However, which PRRs are involved, how they recognize alginate, and whether alginate material characteristics and compositions can elicit …
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Combinatorial lipid-like materials for intracellular delivery of small RNAs that activate innate antiviral immune responses and adjuvant vaccines
… can also activate an innate immune response. Recognition of RNA by specialized immune cells occurs through pattern recognition receptors, which have evolved to respond to RNA viruses, such as the Toll-like receptors (TLR) 7 and 8 located in the endosome of dendritic cells. Tailoring the …
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Sensing of Picornavirus Infections
The sensing of viral infection through pattern recognition receptors is necessary to trigger an immune response through the expression of interferons (IFNs) and cytokines. For RNA viruses, which replicate in the cytoplasm, the cytoplasmic RIG-I like receptors are responsible for this sensing. The …
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Dissection of Innate Immunity in Tomato and Tolerance to Bacterial Wilt in Solanaceae species
… by recognizing microbial-associated molecular patterns (MAMPs) and secreted pathogen proteins, called effectors. MAMP-triggered immunity (MTI) relies on recognition of MAMPs by leucine-rich repeats (LRRs) pattern-recognition receptors (PRRs). The best-studied LRR PRR is Flagellin-Sensitive 2 …
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Determining the mechanism of double-stranded RNA-induced cell death in ovarian cancer.
… ligands, such as dsRNA, can activate pattern recognition receptors (PRRs) that are capable of inducing apoptosis. In this dissertation we have found that in ovarian cancer cell lines (DOV-13, SKOV-3, CAOV-3, and OVCAR-3), dsRNA treatment alters cell survival. When treated with dsRNA, …
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Mapping the immunological receptors CD14 and macrophage receptor with collagenous structure (MARCO) and their innate recognition potential on trophoblast cells: relevance for human pregnancy
… immune system. Pathogens are detected through pattern recognition receptors, which have a key role in the innate recognition by transducing signals from pathogen-associated molecular patterns. Lipopolysaccharide, a PAMP of Gram-negative bacterium, is recognized by the Toll-like receptor. …
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LPS, A TLR-4 AGONIST AND VIPER A TLR-4 INHIBITOR UPREGULATE PHAGOCYTOSIS OF ZYMOSAN IN BV2 CELLS
… The main pathogen-associated molecular pattern (PAMP) for <em>Candida</em> is its fungal cell wall, which consists of structural carbohydrates β-1,3 glucan and O-mannan, recognized by pattern recognition receptors (PRR) β-glucan receptors found on the surface of microglia.<strong> …
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The essential, nonredundant roles of RIG-I and MDA5 in detecting and controlling West Nile virus infection
Virus recognition and response by the innate immune system are critical components of host defense against infection. Activation of cell-intrinsic immunity and optimal priming of adaptive immunity against West Nile virus (WNV), an emerging vector-borne virus, depends on recognition by RIG-I and …
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The Modulation of Innate Immunity by Cellular and Viral Noncoding RNAs
… endogenous non-coding RNAs can be recognized by pattern recognition receptors to trigger innate immune activation and inflammation. Many positive sense RNA viruses also produce non-coding RNAs. This includes Dengue virus 2 (DENV-2), which produces subgenomic flaviviral RNA (sfRNA), capable of …
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Investigation of the molecular basis of PAMP-induced resistance
The recognition of conserved microbial features termed pathogen-associated molecular patterns (PAMPs) by surface-localized pattern-recognition receptors (PRRs) constitutes the first layer of plant innate immunity. Although details of early immune signaling events are starting to be unveiled, the …
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Examining the Role of Non-Canonical NOD-like Receptors and Inflammasomes in Inflammation and Disease
The NOD-like Receptors (NLRs) are a family of pattern recognition receptors known to regulate a variety of immune signaling pathways. A substantial portion of NLR research focuses on the pyrin domain-containing NLRP subfamily. The canonical NLRPs are inflammasome-forming proteins responsible for …
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Bacteroides fragilis outer membrane vesicles are used for secretion of a discrete subset of bacterial RNAs that stimulate an immune response in colonic epithelial cells.
… of the inflammatory response system are receptors capable of sensing foreign nucleic acids (e.g. small RNAs) that are carried as cargo in bacterial outer membrane vesicles (OMVs). The mechanisms by which human extracellular RNAs elicit immune responses have been well established, while …
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