Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 301 for “"Patient-derived"”.
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Tumour ecology of breast cancer patient-derived xenografts
… and dynamic ways. Descriptive studies in patient material, although extremely informative, often lack the temporal and spatial resolution needed to fully recapitulate this variability. Mouse models represent a natural complement to these correlative analyses, allowing longitudinal and …
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Thematic analysis of patient derived quality measures following upper limb surgery
… study investigated how upper limb post-operative patients defined quality care. We specifically assessed the following three aims: (1) determining patient expectations following upper limb surgery, (2) identifying patient recognized barriers to receiving quality care, and (3) analyzing patient …
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An Investigation into the Vascular Phenotypes of Breast Patient- Derived Xenografts
… in a preclinical setting but also throughout a patient’s treatment regime, particularly in breast cancer management. Thus far there has been a reliance on cell-line mouse models to provide insight into tumour vascular phenotypes captured with PAI. As a result, several questions remain regarding …
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Modeling Cancer Using Li-Fraumeni Syndrome Patient-Derived Induced Pluripotent Stem Cells
… novel disease model platform by reprograming LFS patients' fibroblasts to induced pluripotent stem cells (iPSCs), and further differentiate these iPSCs into mesenchymal stem cells (MSCs) then to osteoblasts (OBs), the cells from which osteosarcomas originate. Interestingly, LFS iPSC-derived …
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MODELLING GBA1-RELATED PARKINSON¿S DISEASE PATHOLOGY IN PATIENT-DERIVED MIDBRAIN ORGANOIDS
… an innovative midbrain organoid culture system derived from subjects with GBA1-related Parkinson’s disease and Gaucher’s disease as the first patient-based model able to reproduce fundamental human neuropathological features of these disorders. We provide evidence of glucosylceramide …
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IDENTIFICATION OF CANCER- AND METASTASIS-RELATED EPIGENETIC DYNAMICS USING PATIENT-DERIVED ORGANOIDS
… selectively activated in colorectal cancer (CRC) patient-derived organoids (PDOs) with respect to the normal counterpart that are also conserved among different CRC subtypes, suggesting the presence of shared epigenetic mechanisms that are activated despite heterogeneous mutational landscapes. …
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Metabolomic Investigation of Melanoma Metastasis in a Patient-Derived Xenograft Mouse Model
… to prevent metastatic cancer. We used a set of patient-derived xenograft mouse models of melanoma, in which the metastatic potential of individual tumor lines correlated strongly with the history of metastasis in the patient donors. Six tumor lines with low metastatic potential (L-met) and nine …
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Investigation of metabolism in glioblastoma patient-derived xenografts using deuterium metabolic imaging
… used to study glucose and acetate metabolism in patient-derived xenografts (PDX) of glioblastoma in mice and rats respectively. Using 2H-labelled glucose, I showed that despite exhibiting the same concentration of glucose within the tumour, glycolytic PDX subtypes produced more labelled lactate …
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MODELING FACIOSCAPULOHUMERAL MUSCULAR DYSTROPHY USING PRIMARY AND PATIENT-DERIVED INDUCED PLURIPOTENT STEM CELLS
… iPS cells, meaning that any cell type in an FSHD patient could be subject to deregulation by DUX4. DUX4 recruits p300 to induce global changes in histone acetylation, massively disrupting gene expression, thus pathology is not obviously exclusive to myogenic cells. Why the disease is …
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PNPLA3 P.I148M VARIANT INCREASES LIPID DROPLETS NUMBER AND SIZE IN PATIENT-DERIVED LIVER ORGANOIDS
… To overcome this gap in knowledge, we generated patient-derived human liver organoids (HLOs) and studied lipid accumulation across different PNPLA3 genotypes. HLOs were differentiated toward a hepatocyte-like phenotype (Hep-HLO) and exposed to 300 μM Palmitic and Oleic fatty acids (FAs) for 72h. …
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Investigating the expression of plasma membrane calcium ATPase (PMCA) in patient-derived glioblastoma cultures
… research, the median survival for glioblastoma patients remains approximately 15 months, and recurrence is almost universal. In light of these challenges, this thesis explores the role of Plasma Membrane Calcium ATPases (PMCAs) in the pathology of glioblastoma, with a specific focus on isoforms …
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The development and validation of a novel patient-derived 3D meningioma cell culture model
… study, I established an easy-to-use in vitro patient-derived meningioma spheroid model that maintained the morphological and molecular features of the parental tumours, including tissue histology, the tumour microenvironment, and the mutational profile. Comprehensive characterisation of the …
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Investigating circuit and spatial heterogeneity of human brain tumors with patient-derived organoid models
… to unravel GBM heterogeneity by leveraging patient-derived GBM organoids (GBOs), a 3-dimensional model inspired by human brain organoids. In the first sections of this dissertation, I describe the application of circuit neuroscience techniques to study diverse tumor-neuron circuitry. …
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Modelling Prenatal Hypoxia As A Risk Factor For Schizophrenia Vulnerability In Patient-Derived Cerebral Organoids
… using induced pluripotent stem cells (iPSCs) derived from healthy control or SCZ patient cell lines to address these questions. This creates a platform that allows for the investigation into the pathophysiology of SCZ and hypoxia in tandem. Organoids were exposed to hypoxic conditions at one …
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Cytosolic Nucleic Acid Sensing and Senescence in a Patient-Derived Model of Progressive Multiple Sclerosis
… For reasons not yet fully understood, most patients eventually transition to a disease stage known as progressive MS (P-MS), involving a shift from adaptive immune disease mechanisms to a CNS-compartmentalised innate immune response. During P-MS, the inflammatory activity of CNS-resident …
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Metabolic control of neural stem cell function in a patient-derived model of multiple sclerosis
… For reasons that remain unclear, the majority of patients eventually enter a disease stage termed progressive MS (PMS), which is characterised by a substantial failure of the main endogenous brain repair mechanism seen in the early stages of the disease. During this period, patients experience a …
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