Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 38 for “"Patient stratification"”.
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Quantitative dynamics of T-cell receptor repertoires and their use for cancer patient stratification
… and identify TCR clones with potential use for patient stratification based on their mutational status for the hotspot mutation IDH1 R132H in glioma. First, in Chapter 2 we deeply characterised the statistical properties of data generated from TCR repertoire sequencing, in order to understand …
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Integrated computational and experimental analysis of non-neuronal cell molecular mechanisms contributing to Alzheimer's disease progression
… modeling to analyze matched protein-level and AD patient outcome data to identify oligodendrocyte contributions to patient stratification. We focused on histopathological outcomes to identify a tau/oligodendrocyte basis for patient stratification. Subsequently, we modeled distinct stages of …
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Novel multi-parametric, multi-modality imaging for the assessment of tumour biology in renal cell carcinoma
… and metabolically heterogeneous. Inaccurate patient stratification limits the treatment of RCC. This thesis investigates imaging techniques and image-analysis methods ranging from easily transferrable to highly specialised and dependent on dedicated infrastructure. Artificial intelligence …
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Interpreting transcriptional signatures and their relevance to disease biology, prognosis and treatment resistance in colorectal cancer
… strategies further in the future. Therefore, patient stratification is paramount in order to improve patient response to treatment, improve survival outcome and reduce the risk of relapse. Computational algorithms using a bioinformatics approach have enabled the stratification of patients …
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Biologically Interpretable Representation Learning for Mechanistic Insights into Cancer Immunotherapy Resistance
… RNA-seq and wholeexome sequencing data from 366 patients across melanoma, renal cell, urothelial, and gastric cancers, BDVAE learns low-dimensional latent representations that are both predictive of response and biologically meaningful. The model reveals distinct latent dimensions aligned with …
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Multiplatform metabolome profiling to identify specific signatures and biomarkers in blood samples: untargeted approach
… for unambiguously distinguishing diseased patients from healthy ones providing results in rapid time. In this doctoral thesis, an untargeted metabolomics approach based on high-throughput analytical techniques such as vibrational spectroscopy and liquid chromatography-mass spectrometry …
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Coordinated Blockade of TGF-β and PD-L1 Promotes Anti-Tumor Immunity in Ovarian Cancer Models
… HGSC, with no approved immunotherapy options for patients. This is due to an immunosuppressive tumor immune microenvironment (TIME) that limits the efficacy of ICB. Resistance to immunotherapy is driven in part by TGF-β signaling in the ovarian TIME, leading to immune suppression, metastasis, and …
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Functional Analysis of Risk Single Nucleotide Polymorphism and Long Noncoding RNA in Prostate Cancer
… worldwide. While most low-risk prostate cancer patients have a favourable clinical outcome, intermediate- and high-risk patients with aggressive forms of the disease often relapse despite the initially effective local and conventional androgen-deprivation therapies. Therefore, two main …
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Dissecting The Mechanisms of Venetoclax Resistance In Myelodysplastic Syndromes
… therapy. However, only 50 percent of the patients respond, with transient effects and no approved second-line treatment options after their diseases progress to acute myeloid leukemia (AML). The mechanisms that govern HMA failure are unknown. Recently, we unveiled that MDS are maintained …
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Investigation of Quatitative Image Features From Pretreatment Ct and Fdg-Pet Scans In Stage Iii Nsclc Patients Undergoing Defintive Radiation Therapy
… QIFs were used to quantitatively characterize patient disease as seen on imaging. A leave-one-out cross-validation procedure was used to assess the prognostic ability of QIFs extracted from CT and PET in addition to conventional prognostic factors (CPFs). QIFs were found to improve model fit …
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Identification of MEN1 loss-off function as a potential biomarker for immune checkpoint therapy
… response to treatment and therefore stratify patient care. Blockade of PD- 1/PD-L1 (Programmed death receptor (ligand) 1) has shown potent antitumor activity but therapies are limited by a lack of patient stratification. It was hypothesised that loss of tumour suppressor genes (TSGs), not …
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Evaluating Digital Health Technologies to Advance Parkinson's Disease Care
… PD service provision does not meet the needs of patients, and puts pressure on services with limited capacity. Digital Health Technologies (DHTs), including body-worn sensors and portable devices, may provide advantages, by enabling continual and objective monitoring of symptoms, and facilitating …
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Nucleosome repositioning in glioblastoma
… adults, with highly aggressive behaviour and low patient survival. The glial cells that are responsible for forming GBM show abnormalities in gene expression that can be caused by genetic or epigenetic causes. In particular, the positioning of nucleosomes along the genome determines the …
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Molecular and Mechanical Heterogeneity in Adult and Paediatric High-Grade Glioma
… display a high degree of heterogeneity among patients, as well as within individual patients’ tumours, posing a significant challenge to effective treatment. Recent work has advanced our understanding of molecular variation among adult and paediatric HGGs, providing definitions of tumour …
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PLASMA JNK3 AS A NOVEL PERIPHERAL BIOMARKER IN ALZHEIMER'S AND PARKINSON'S DISEASES: EARLY DIAGNOSIS AND DISEASE MONITORING
… both AD and PD. In the AD cohort, which included patients with AD, mild cognitive impairment (MCI), and controls (CTR), JNK3 levels were measured in both cerebrospinal fluid (CSF) and plasma. Plasmatic JNK3 levels were significantly increased in MCI patients compared to both AD patients and …
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Exploring potential inhibitors of the HGF-Met signalling pathway as a prospective treatment for paediatric medulloblastoma
… for new therapeutic treatments for cancer patients. The brain tumour Medulloblastoma is the leading cause of cancer-related death in children and infants meaning research into better treatment of this cancer is vital. Using cell culture model systems and bioinformatics resources, this …
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Single-cell Functional Profiling of Lymphocytes for Cancer Immunotherapy
Immunotherapy by harnessing patients’ the immune system has changed the landscape of cancer therapeutics and shown promising and remarkable clinical responses. However, not all the patients would be beneficial from the treatment. Lymphocytes are a significant target in anti-tumor immunotherapy, and …
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Interrogating Cancer Metabolism using Novel Imaging Techniques
… cell proliferation was confirmed in glioblastoma patient derived cells and tumours and BCAT1 was shown to regulate the cells’ metabolic and transcriptional profiles through regulation of alpha-ketoglutarate metabolism. In vivo imaging of BCAT1 activity is therefore suggested as a potential …
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Modelling timing in blood cancers
… has found that Myeloproliferative Neoplasms patients with both JAK2 and TET2 mutations have different disease characteristics with distinct mutation order. My analyses identify HOXA9 as a potential prognosis marker and biological switch responsible for patient stratification in these patients …
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Tumour Associated Neutrophils as a Potential Biomarker for Anti-PD-1 Immunotherapy in Non-Small Cell Lung Carcinoma: An Automated Approach
… are limited in their ability to stratify patients for predicting response, highlighting the need for novel biomarkers to better guide therapeutic strategies. Tumour associated neutrophils (TANs) can influence non-response to immunotherapy and have been explored using manual scoring …
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