Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 10 of 10 for “"Patient Derived Xenograft Models"”.
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Identification of new therapeutic targets for undifferentiated pleomorphic sarcoma
… screening in well-annotated preclinical models is a promising approach to identifying novel compounds for further research. This project aims to (i) develop and characterise novel models of UPS from patient-derived xenograft models, (ii) identify compounds and target classes efficacious …
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Investigating the Mechanisms of Resistance to Dual PI3K/MTOR Inhibitor in PIK3CA Mutant Basal Like Bladder Cancer
… to targeted therapies and thereby provide patients with maximal clinical benefit. Using two MIBC patient derived xenograft models (PDX) that carry alterations in PI3K signaling, one of the most dysregulated signaling pathways in bladder cancer, we studied determinants of response to PI3K …
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Interrogating therapeutic resistance to oncogenic KRASG12C-based therapies in colorectal cancer
… States. Although KRAS is mutated in 50% of patients with metastatic CRC (mCRC), it has historically been a challenging therapeutic target. The recent approval of novel covalent inhibitors selective for KRASG12C mutation have entered the clinic, which has not only marked a major milestone in …
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APPLICATION OF STRUCTURAL, MOLECULAR, AND PROTOEMIC STUDIES TO INVESTIGATE ON-TARGET AND OFF-TARGET MECHANISMS OF LORLATINIB RESISTANCE IN ALK DRIVEN NEUROBLASTOMA
… have seen tremendous improvement in cancer patient survival because of development of targeted therapies. In neuroblastoma, a common childhood cancer, approval of anti-GD2 immune therapy has improved patient survival and discovery of anaplastic lymphoma kinase (ALK) receptor activating …
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Simultaneous Targeting of CDK4/6 and BETs is Independent of RB Status in Osteosarcoma
… both treatment-naïve and previously treated OS patient-derived xenograft models. In a lung-metastatic OS model, CDK4/6i alone markedly reduced metastatic burden; however, at the tested BETi exposure, the addition of BETi did not further decrease metastatic foci. These results underscore the …
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53BP1 and double-strand break repair pathway choice in cancer
… resistance across a panel of BRCA1-deficient patient-derived xenograft models. Promisingly, this mechanism may impart an acquired vulnerability to cisplatin or radiotherapy. Thus, we have characterised a critical component of the 53BP1 axis which is deterministic in repair pathway choice and …
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RNA Therapeutics for Fibrolamellar Hepatocellular Carcinoma
… in the cell death of FLC cells in vitro and in patient derived xenograft models of FLC in mice. These results show that DNAJB1::PRKACA has a pivotal role in tumor formation, maintenance, and progression and that FLC is oncogenically dependent on DNAJB1::PRKACA. This validates DNAJB1::PRKACA as a …
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Characterising the role of TET2 in oestrogen receptor positive breast cancer
… events in both ER+ breast cancer cell lines and patient-derived xenograft models. ER was shown to bind at several sites upstream of the TET2 promoter, supporting multiple existing studies proposing TET2 as an ER target gene. A key role for TET2 in the ER complex was further reinforced using …
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Exploring vasculogenic mimicry and anti-angiogenic therapy resistance within breast cancer patient-derived tissue xenograft models
… VM and its relationship with AAT resistance in patient-derived tissue xenograft (PDTX) models of breast cancer by utilising bulk and single-cell transcriptomic data and developing optimised VM vessel visualisation modalities. A 3D imaging modality which is capable of visualising both host …
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Investigating the Genomics and Heterogeneity of Childhood Non-Hodgkin Lymphoma
… high-intensity chemotherapy. Unfortunately, many patients who relapse have a dismal prognosis, with long-term survival less than 30% for relapsed BL patients in particular. Furthermore, the side effects of chemotherapy on children are often severe, rendering intensive chemotherapy infeasible in …