Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"Pathology, Molecular"”.
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The application of genomic technologies to cancer and companion diagnostics.
… a wave of change in our understanding of its molecular pathology. Molecular pathology and personalised medicine are being driven by discoveries in genomics, and genomics is being driven by the development of faster, better and cheaper genome sequencing. The next decade is likely to see …
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Mitochondrial inheritance and cell cycle regulation in Saccharomyces cerevisiae
Movement and positional control of mitochondria and other organelles are coordinated with cell cycle progression in the budding yeast, Saccharomyces cerevisiae. Recent studies have revealed a checkpoint that inhibits cytokinesis when there are severe defects in mitochondrial inheritance. An …
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Intra-Regional Differences in Cerebellar Vulnerability of Spinocerebellar Ataxia Type 1 Mice
… vermis and hemispheres exhibiting worse pathology. Mouse models of SCA1 have been critical to increasing our understanding of mutant ATXN1 toxicity, however most studies only assessed cerebellar degeneration from one lobule or with bulk cerebellar tissue.As a consequence, a question that …
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Studies of verticillium wilt and characterization of candidate verticillium wilt resistance genes in the mint species Mentha longifolia (L) Huds
… populations for wilt resistance screening and molecular genetic study, including cloning of candidate verticillium wilt resistance genes.</p><p>A collection of fourteen Mentha longifolia accessions from Europe, Asia and South Africa was analyzed for morphological traits, oil composition, and …
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<i>Maize fine streak virus</i> (MFSV) gene expression and protein interaction
… by means of yeast two-hybrid (YTH) and bimolecular fluorescence complementation (BiFC). The MFSV 3 and 4 proteins strongly interacted with each other in both assays, suggesting that this interaction is likely to occur in nature. Based on the location of MFSV 4 in the genome, the size of …
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The Intrinsic Caspase Death Pathway in Stroke Neurodegeneration
… of apoptosis that are activated in distinct molecular pathways, but their impact in stroke is poorly defined. Direct evidence for caspase activation in stroke and the functional relevance of this activity has not been previously characterized. For this dissertation, we developed an unbiased …
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Exploring Genome Structure and Gene Regulation Related to Virulence in Fungal Phytopathogens Using Next Generation Sequencing Techniques
Over the last decade, a technological revolution has provided enormous advances in the knowledge of complex biological processes largely enabled by the development of next-generation sequencing (NGS) techniques. Applications of NGS include studies of entire genomes, characterization of the entire …
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Men and Women are Not Just From Different Planets: The Role of Sex-Based Differences in the Prevention of Non-Melanoma Skin Cancer
There are over 3.5 million new diagnoses of skin cancer each year in more than 2 million patients, making skin cancer more prevalent than all other cancers. While the risk of developing cutaneous squamous cell carcinoma, the more deadly type of non-melanoma skin cancer, is three times greater in …