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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.

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Showing 1 to 11 of 11 for “"Pathological response"”.

  1. Pathological response of breast cancer to neo-adjuvant chemotherapy at a single tertiary centre with no access to Trastuzumab

    Khamajeet, ArvinDivision of General Surgery2024

    … cancer patients, specifically focusing on the response of local patients who are HER2-positive and do not receive Trastuzumab. Methods A retrospective audit was conducted on all patients who underwent NACT followed by surgical intervention, to assess response, between 1 January 2017 and 31 …

    cape-town Repository record

  2. Prediction of axillary lymph node metastasis and the pathological response to neoadjuvant chemotherapy in patients with primary breast cancer using a decision tree-based model

    Takada, MasahiroKyoto University2012

    kyoto Repository record

  3. PET-MR Imaging of Hypoxia and Vascularity in Breast Cancer

    Carmona-Bozo, Julia CarlotaUniversity of Cambridge2021

    … characterisation and early biomarkers of tumour response. Due to their ability to assess physiological processes in vivo, positron emission tomography (PET) and MRI can provide non-invasive characterisation of the tumour microenvironment, including perfusion, vascular permeability, cellularity …

    cambridge Repository record

  4. The Role of Chromatin Remodeling in Hippocampus in Depression and Antidepressant Action

    Tsankova, Nadejda Mincheva2010

    … effect, and that HDAC5 deficiency reduces the pathological response to stress. This unexpected role for HDAC5 provides an important mechanistic link between the adaptive chromatin remodeling changes at genes and the ability of chronic antidepressants to exert therapeutic efficacy after chronic …

    utswmed Repository record

  5. The Role of Protein S-glutathionylation on Ca2+ Signaling in Cultured Aortic Endothelial Cells

    Lock, Jeffrey T.Case Western Reserve University School of Graduate Studies2013

    … in protein S-glutathionylation is a common response to oxidative stress; however, the role of glutathionylation in Ca2+ homeostasis and Ca2+ signaling processes is not well understood. Diamide, a membrane-permeable oxidizing reagent, rapidly and reversibly converts glutathione (GSH) to its …

    ohiolink Repository record

  6. A pathways-based approach identifying determinants of drug resistance in oesophageal adenocarcinoma

    McCabe, NiamhQueen's University Belfast2021

    … less than 20% of patients experiencing complete pathological response, so the discovery of underlying resistance mechanisms and novel agents to target these pathways is crucial.<br/><br/>Materials and Methods: <br/>273 pre-treatment OAC biopsies were transcriptionally profiled using the Almac …

    qu-belfast Repository record

  7. Streptococcus pyogenes - a manipulator of human defences

    Kahn, FredrikDivision of Infection Medicine2012

    … with fibrinogen and that these can elicit a pathological response, which may contribute to the massive vascular leakage present in streptococ¬cal toxic shock (STSS). This thesis demonstrates that preformed antibodies against certain epitopes on the M protein contribute to triggering the …

    lund Repository record

  8. RUOLO DELLA STIMOLAZIONE VAGALE SULLA PROLIFERAZIONE DEI FIBROBLASTI CARDIACI IN VIVO IN MODELLO ANIMALE DI FIBRILLAZIONE ATRIALE.

    C. DE ASMUNDISUniversità degli Studi di Milano2010

    Introduction: Cardiac fibrosis is a pathological response that causes abnormalities in cardiac conduction and mechanical function, thereby contributing to the pathophysiology of a variety of cardiac conditions, including hypertrophy, failure, and arrhythmias. Atrial fibrillation (AF) is the most …

    milano Repository record

  9. MiRNA-Mediated Regulation of Colorectal Tumorigenesis

    Moore, Ashleigh Eleanor

    … for uncontrolled gene expression and cellular responses that lead to the development of cancer. MicroRNAs (miRNAs) are small non-coding RNAs that have emerged as essential mediators of post-transcriptional gene regulation and are being increasingly recognized for their role in cancer. MiRNA …

    south-carolina Repository record

  10. Cellular and molecular mechanisms of response to, and recurrence following, breast radiotherapy

    Lightowlers, SaraUniversity of Cambridge2025

    This thesis explores response to, and recurrence following, radiotherapy in primary breast cancer within three clinical trials investigating aspects of radiation management: the IMPORT trials, IMPORT LOW and IMPORT HIGH, and the NeoRT trial. Clinical outcomes from the NeoRT trial are described as …

    cambridge Repository record

  11. Mild Traumatic Brain Injury with Associated Visual System Dysfunction: Investigating Histopathology, Functional Correlates, and a Novel Therapeutic Immune Modulator

    Guley, Natalie M.2016

    … of the brain’s reaction to trauma is an immune response that can cause additional long-term damage above and beyond that of the initial injury. This response was observed in our model as regions of microglial cell activation throughout areas of the brain important for visual processing. A novel …

    tenn-hsc Repository record