Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 1900 for “"Pathological"”.
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Mechanisms of pathological adipogenesis
… understanding of the mechanisms underlying pathological adipogenesis in bone may provide interesting therapeutic targets for disorders such as osteoporosis.
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Pathological vs non-pathological incapacity: are the differences in requirements and consequences justified?
This paper covers the criminal law defences of pathological incapacity and non-pathological incapacity in South African law which are used by defendants in criminal cases to refute the element of capacity that is necessary for the court to hold the accused criminally liable. Each defence has its …
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Characterizing 3D epigenomes in pathological conditions
… of 3D epigenomes in two distinct pathological contexts: Trisomy 21 neural stem cells and cells acutely infected with SARS-CoV-2. For Trisomy 21 cells, I applied a cutting-edge, combinatorial indexing-based single-cell RNA sequencing approach to chart the developmental progression …
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Studies on Macrophage Migration in Pathological Contexts
Macrophages play key roles following nerve injury releasing cytokines and chemokines thought to be involved in the development and maintenance of neuropathic pain. ATP is a transporter of chemical energy, but can also act as an extracellular signalling molecule that signals through purinergic …
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Pathological features of mitochondrial respiratory chain dysfunction
Mitochondria are essential organelles that carry out a multitude of important metabolic processes in mammalian organisms. These processes include ATP generation by the respiratory chain, aspartate synthesis by matrix aminotransferases, and long-chain fatty acid catabolism by the beta oxidation …
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A computer model for investigating the biomechanical effects of radiation exposure on pathological and non-pathological living human cells
The cellular response to radiation insult and studies have been carried out to investigate aspects of the cytoskeleton and the force response of the cell when probed by an AFM. Confirmed for the first time that there was a statistically significant difference for the PNT2 and PC3 cell lines in …
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FHL2 Inhibits Calcineurin and Represses Pathological Cardiac Hypertrophy
… cardiac hypertrophy is a hallmark feature of pathological remodeling which, left unchecked, predisposes hearts to arrhythmia and failure. FHL2 is a member of the four-and-a-half LIM domain (FHL) family of proteins expressed predominantly in the heart. Targeted disruption of FHL2 leads to an …
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Correlates of Measures of Adaptive and Pathological Narcissism
… the NPI does indeed measure some maladaptive or pathological aspects of narcissism. Narcissistic Entitlement, Exploitativeness, and Exhibitionism, as captured by the NPI, were associated with a multitude of negative, maladaptive outcomes (e.g., elements of psychopathy and pathological narcissism, …
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Epidemiological and pathological correlates of early neonatal mortality
INTRODUCTION Despite improved intrapartum monitoring of the fetus, the rate of cerebral palsy has not decreased. Many studies now suggest that the majority of children with such disability may sustain damage in utero. Current understanding and identification of antenatal brain injury is poor and …
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Pathological, Immunohistochemical and Molecular Analysis of Recurrent Glioblastoma
Glioblastoma is the most frequent and most malignant neoplasm of the brain. Most of glioblastomas recur or progress despite primary treatments. However, clinical significance of pathologic diagnosis of recurrent glioblastoma is controversial. To evaluate the prognostic value of the volume of …
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The functional and pathological pathways of α-Synuclein
… the intricate balance between functional and pathological behaviours of αS. The second part of this PhD investigates the aggregation of αS under quiescent conditions. At low pH, as found in the lysosomal pathway, the cholesterol in SL-SUVs significantly accelerates the aggregation of αS and …
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The spread of pathological assemblies in neurodegenerative disease
… itself in the gut or nose might trigger this pathological pathway, whether or not it is the causative agent in the environment. Here, we prepared pathological forms of α-synuclein and studied its administration into experimental animals via a variety of routes, including oral, nasal, and …
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Post-alcoholic hypoglycaemia: a clinical and pathological study
For a number of years a history of sudden onset of coma, followed later by death, was noted amongst Africans at King Edward VIII hospital, Durban. Necropsy, where performed, revealed no cause in many of these patients. In 1957 after cerebrospinal fluid had been examined in some of the cases it was …
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