Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"Pathogenic T cells"”.
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THE DEVELOPMENT OF SELECTIVE PHOTOSENSITIZERS TO TARGET PATHOGENIC T CELLS AND PREVENT GRAFT-VERSUS-HOST DISEASE
… the recipient's tissues from donor allogeneic T cells. In cutaneous T cell lymphoma (CTCL), malignant T cells migrate throughout the skin to mediate the disease. Consequently, developing new therapeutics to selectively target pathogenic and malignant T cells may improve clinical outcomes. In the …
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Non-conventional Regulation of Treg Development and Function
… due to the potential to disrupt migration of pathogenic T cells to the gut. However clinical trials indicate a protracted therapeutic response. Recent studies have indicated an immunomodulatory role for chemokines in other autoimmune diseases. Metabolism is another factor whose influence on T …
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Pathogenic Mechanisms Underlying Immune Dysregulation Associated To Hypomorphic RAG2 Mutation: Role Of Microbiota At Mucosal Interfaces
… mediated by oligoclonal self-reactive T and B cells, named Omenn Syndrome (OS). The clinical and immunological spectrum of OS presentation is extremely broad. Commonly, patients present symptoms very similar to graft-versus-host disease (GVHD) as inflammatory reactions particularly involve the …
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IDENTIFICATION OF ADHERENT-INVASIVE ESCHERICHIA COLI (AIEC) VIRULENCE DETERMINANTS LEADING TO ACTIVATION OF PATHOGENIC TH17 CELLS IN CROHN¿S DISEASE.
… from the overly activation of tissue-resident T-cells in response to a dysbiotic composition of the gut microbiota. In particular, the pathogenesis of CD has been linked to a significant enrichment of pathogenic IFNγ-producing Th17 cells with a concomitant selective and significant enrichment of …
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FUNCTIONAL CHARACTERIZATION OF THE INTERACTION BETWEENP. AERUGINOSA AND DENDRITIC CELLS TRIGGERING THE DIFFERENTIATION OF PATHOGENIC TH1/17 CELLS IN CYSTIC FIBROSIS.
La fibrosi cistica (CF) è una malattia genetica caratterizzata da una risposta infiammatoria cronica ed eccessiva a infezioni polmonari persistenti, prevalentemente causate da Pseudomonas aeruginosa (Pa). Nonostante l’ambiente polmonare ostile generato dalla disfunzione del CFTR, Pa è in grado …