Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"Pathogenesis of diabetes"”.
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Stress-inducible Mig6 promotes pancreatic beta cell destruction in the pathogenesis of diabetes
… beta cell failure is central to the development of diabetes. Therapeutic applications targeted at understanding and manipulating beta cell destruction mechanisms should enhance the preservation of functional beta cell mass and prevent diabetes. To this end, we have demonstrated that diabetogenic …
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The effects of diet varying in fat content on the pathogenesis of diabetes mellitus in wistar rat offspring
Aims/hypothesis: The incidence of type 2 diabetes (T2D) is increasing globally. T2D is characterised by progressive deterioration of glycaemic control. These changes in glucose homeostasis are primarily due to ?-cell secretory dysfunction and/or peripheral insulin resistance. Studies show that …
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Premature vascular senescence during diabetic retinopathy
Cellular senescence is the permanent state of growth arrest with significant phenotypic changes including the senescence-associated secretory phenotype (SASP) and triggered by mechanisms such as telomere shortening and DNA damage. Diabetes is associated with endothelial dysfunction, which is …
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Association of autoimmune thyroid disease and type 1 diabetes
… mune thyroid failure, as evidenced by elevation of the serum thyrotro¬ phs concentration, was twice as common in insulin-dependent as in noninsulin- dependent diabetics. In contrast to the general insulindependent diabetic population, insulin- dependent diabetics with overt and clinically …
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Glucosensing, Hypoglycemia, and the Brain
… for normal glucose homeostasis and disruption of GLUT4 translocation in these tissues leads to glucose intolerance and insulin resistance, hallmarks of Type 2 diabetes. Within the brain, specialized glucose sensing neurons regulate whole body glucose homeostasis. Unlike GLUT4's role in the …
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Investigation of potential intervention targets to improve insulin action: a therapeutic approach
… (insulin resistance) is a key factor in the pathogenesis of diabetes mellitus. To investigate therapeutic targets against insulin resistance, this thesis explores the mechanism of action of pharmacological agents and exogenous peptides known or suspected to modify insulin action. These …
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Role Of Hyperglycemia, Hypoglycemia, and Glucose Transporter 4 on Brain Glucose Sensing, Counterregulation, and Neuronal Viability
… whole body energy homeostasis. Disruption of brain glucose sensing results in impaired glucose tolerance, a hallmark in the pathogenesis of diabetes, as well as increased risk of severe hypoglycemia as occurs with insulin therapy. Thus, understanding how the brain senses and responds to …
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Acquired copper imbalance in diabetes-induced cardiac disease: Molecular mechanisms and reversibility
Diabetes is a metabolic disorder characterised by chronic hyperglycaemia, which results from disruption of several glucose-control mechanisms. In diabetic patients, it is well established that prolonged hyperglycaemia increases the risk of the cardiovascular complications, which are responsible for …
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Clinical and pathological characterization of a novel transgenic animal model of diabetes mellitus expressing a dominant negative glucose-dependent insulinotropic polypeptide receptor (GIPR dn)
Clinical and pathological characterization of a novel transgenic animal model of diabetes mellitus expressing a dominant negative glucose-dependent insulinotropic polypeptide receptor (GIPR dn) Gastrointestinal hormones like glucose-dependent insulinotropic polypeptide have recently been shown to …
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Glycaemic control in pregnancies complicated by type 1 diabetes
Type 1 diabetes in pregnancy is associated with higher rates of maternal and infant complications. The complications are associated with maternal hyperglycaemia. Thus, the main goal of treatment for these women is to optimise glycaemic control and thereby improve clinical outcomes for themselves …
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Small molecule kaempferol, a novel regulator of glucose homeostasis in diabetes
Diabetes mellitus is a growing public health concern, presently affecting 25.8 million or 8.3% of the American population. While the availability of novel drugs, techniques, and surgical intervention has improved the survival rate of individuals with diabetes, the prevalence of diabetes is still …
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Role of nuclear factor kappa B (NFkB) in the vascular complications of diabetes.
Diabetes mellitus (DM) is the most common metabolic disease worldwide. This condition accounts for the majority of renal failure and blindness in adults aged between 20 to 74 years of age. After 20 years, some of type 1 diabetic patients and around 60% of type 2 diabetic patients will be diagnosed …