Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 2234 for “"Pathogenesis"”.
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Psoriasis: therapy and pathogenesis
Contains fulltext : mmubn000001_027415538.pdf (Publisher’s version ) (Open Access)
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Molecular Pathogenesis of MALT lymphoma
Mucosa associated lymphoid tissue (MALT) lymphoma is characterized by t(11;18)(q21;q21)/API2-MALT1, t(1;14)(p22;q32)/BCL10-IGH and t(14;18)(q32;q21)/IGH-MALT1, which commonly activate the NF-κB pathway. Gastric MALT lymphomas harbouring such translocation do not respond to Helicobacter pylori …
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Mitochondrial parts, pathways, and pathogenesis
Mitochondria are cellular compartments that perform essential roles in energy metabolism, ion homeostasis, and apoptosis. Mitochondrial dysfunction causes disease in 1 in 5,000 live births and also has been associated with aging, neurodegeneration, cancer, and diabetes. To systematically explore …
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Comparative pathogenesis of Yersinia enterocolitica biotypes
Yersinia enterocolitica is a well known food-borne bacterium which belongs to the Enterobacteriaceae family. Y. enterocolitica is pathogenic for humans and it causes a wide spectrum of diseases ranging from self-limiting gastrointestinal diseases to fatal sepsis depending on the age and the …
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The molecular pathogenesis of myeloproliferative neoplasms
Myeloproliferative neoplasms (MPNs) are a heterogeneous group of haematological stem cell<br/>malignancies characterised by proliferation of one or more cells of the myeloid lineage. The molecular<br/>investigation of MPN was revolutionized in 2005 by the finding that approximately 95% of cases …
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The pathogenesis of idiopathic pulmonary fibrosis
… temporal and geographical heterogeneity. As the pathogenesis of this disease is poorly understood, the aim of this work was to investigate the pathobiology of IPF in a prospective manner. There is evidence of a strong association of gastro-esophageal reflux and vascular disease with IPF. …
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Pathogenesis of Fumonisin Toxicosis in Swine
… edema in pigs, but little is known about the pathogenesis of disease. Fumonisins inhibit ceramide synthase in the sphingolipid biosynthetic pathway, but the subsequent elevation of tissue sphingoid bases is not always associated with disease. The goal of these studies was to elucidate the …
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ALK in the pathogenesis of cancer
… Lymphoma Kinase (ALK) has been implicated in the pathogenesis of many types of cancer including Anaplastic Large Cell Lymphoma (ALCL) and neuroblastoma (NB). ALK is an ideal drug target as its endogenous expression is limited to neuronal cells during neonatal development, although resistance to …
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Pathogenesis and Therapy of Mitochondrial Diseases
… Despite being relatively frequent, the molecular pathogenesis of POLG-related diseases is poorly understood and efficient treatments are missing, partly due to the lack of relevant in vivo models. Here, I describe the generation of two mouse models: 1) the PolgA449T/A449T mouse, which reproduces …
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Gut Microbiota Regulation of SLE Pathogenesis
… insights into the dynamic role of B cells in the pathogenesis of SLE. In addition, we delved into the intricate connection between SLE and the gut microbiota. A literature review offered a comprehensive analysis of current research, with a particular emphasis on potential interactions between …
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Molecular dissection of Alternaria brassicicola pathogenesis mechanisms
… was to gain a better understanding of the pathogenesis mechanisms employed by A. brassicicola by identifying and cloning candidate pathogenicity genes. A functional genomics based approach was used to identify candidate pathogenicity genes by creating two suppression subtractive …
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Pathogenesis of experimental tuberculosis in guinea pigs
… both host and pathogen factors contribute to the pathogenesis of lesion necrosis during M. tuberculosis infection. To determine the host factors that contribute to the pathogenesis of lesion necrosis, we focused on the role ROS generation has in the pathogenesis of lesion necrosis in experimental …
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Diabetic foot: microbiology, pathogenesis and glycan studies
… of sialic acid which could be involved in pathogenesis. This sugar may be one of virulence factor employed by this organism in either attachment to the host or to other organisms.
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Molecular Pathogenesis of Spinocerebellar Ataxia type 10
… study is focusing on elucidating a molecular pathogenesis of this unique inherited disease. In this study, we demonstrate normally transcribed ATTCT-repeat forms a lengthy AUUCU pre-mRNA molecule in SCA10 cells, after being completely spliced out. We identify the specific interaction between …
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Molecular Pathogenesis of Spinocerebellar Ataxia type 10
… present study focused on elucidating a molecular pathogenesis of this unique inherited disease. In this study, we demonstrated normally transcribed ATTCT-repeats form a lengthy AUUCU pre-mRNA molecule in SCA10 cells, after being completely spliced out. We identified the specific interaction …
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Carbon Catabolite Regulation of Yersinia pestis Pathogenesis
… of carbon catabolite regulation upon Y. pestis pathogenesis. Specifically, this research encompassed two major aspects: 1) regulation of Y. pestis biofilm formation, a key transmission factor, and 2) characterization of carbon catabolite regulation amid conditions reflective of mammalian …
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Understanding The Pathogenesis of Renal Medullary Carcinoma
<p>Renal medullary carcinoma (RMC) is a lethal cancer that predominantly affects young individuals with sickle cell trait (SCT). It is not currently understood why RMC only affects certain individuals with SCT. We found that patients with RMC more frequently participated in high-intensity exercise …
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