Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"Pathogen evolution"”.
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Computational investigation of pathogen evolution
Pathogen genomes, especially those of viruses, often change rapidly. Changes in pathogen genomes may have important functional implications, for example by altering adaptation to the host or conferring drug resistance. Accumulated genomic changes, many of which are functionally neutral, also serve …
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Population dynamics of infectious disease and pathogen evolution: modelling vaccine escape
… investigates how the risk that an infectious pathogen evolves antigenically (leading to pathogen strains that evade existing immunity) depends on the vaccination coverage of its host population. Deterministic compartmental models are coupled with a parsimonious approach to pathogen evolution, …
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Pathogen evolution within and between hosts with applications to the pneumococcus and SARS-CoV-2
The tracking of a pathogen's evolution over different timescales is essential: for the design of vaccines, to control antibiotic resistance, for the surveillance of disease, to identify transmission chains and to understand the mechanisms behind the pathogen’s evolution. Although the first …
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A new theoretical treatment of pathogen and host evolution
Evolutionary processes are inherently stochastic, since we can never know with certainty exactly how many descendants an individual will leave, or what the phenotypes of those descendants will be. Despite this, models of pathogen evolution have nearly all been deterministic, treating values such as …
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Interplay between spatial structure and competition in ecological communities
… with many species. We then study the case of pathogen evolution, again in the metapopulation framework. We find that intermediate dispersal can act as a strong driver of pathogen evolution. We also study what happens as a population of microbes expands into unexplored territory, known as a …
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Pertussis: Advances in Vaccine Development and Disease Control Strategies
… addresses challenges such as waning immunity, pathogen evolution, and variability in vaccination coverage. By integrating insights into virulence mechanisms and emerging vaccine technologies, this work contributes to a better understanding of the development of vaccine strategies against …
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In silico prediction of host-pathogen protein - protein interactions in the malaria parasite, Plasmodium falciparum
… problem has become more and more crucial. Due to pathogen evolution no efficient vaccine for treatment of malaria currently exists. As infection has developed as a field of study, it became ever more clear that infections could only be understood within the context of the host-pathogen community. …
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MINING SARS-COV-2 PHYLOGENETIC TREES TO ESTIMATE CIRCULATING INFECTIONS AND PATTERNS OF MIGRATION
… on transmission dynamics, emergence and evolution of SARS-CoV-2. However, extracting this information from sequences is difficult, as most methods of analyzing viral genomes were developed for smaller data sets. Therefore, my objective was to develop new fast estimators of the number of …
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Ecological and evolutionary aspects of interactions between microbes coinfecting plants
Coinfections of one host with multiple pathogen species are common, and have important implications for host health and pathogen fitness. In the research reported here, plant virus systems were used to explore the effects of coinfection on pathogen populations and host responses. Chapter 1 …
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Modelling spatial strategies for the durable deployment of crop disease resistance
… of crop disease resistance genes in the face of pathogen evolution is a major challenge in modern agricultural epidemiology. Spatial diversification in the deployment of resistance genes, where susceptible and resistant fields are more closely intermixed, is predicted to drive lower epidemic …
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Optimising fungicide application tactics: using mathematical modelling to understand qualitative and quantitative fungicide resistance management
… threat to food security, and fungal plant pathogens can be particularly damaging due to enormous evolutionary potential. Two major control strategies for fungal pathogens include chemical control with fungicides and use of disease-resistant cultivars. Both strategies are threatened by …
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Elucidating the Role of Phospholipid Scramblase 1 in Antiviral Innate Immunity
<p>Hosts possess an array of defenses against pathogens, some of which form a baseline protective barrier against infection. This baseline resistance, or intrinsic immunity, is the first layer of cellular defense that a virus must evade or antagonize in order to infect a cell. Intrinsic immunity …