Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 16 of 16 for “"Pathogen Recognition Receptors"”.
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Roles of MAVs and MYD88 in Innate and Adaptive Immune Responses to Respiratory Syncytial Virus
Detection of invading viruses by pathogen recognition receptors (PRRs) first illicits an innate immune response which includes the production of anti-viral interferons. TLRs 3, 4, and 7/8 and the RLR, RIG-I, are the primary PRRs involved in the recognition of RNA viruses and they signal through the …
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Biophysical Studies of Pathogen Recognition by C-Type Lectins
C-type lectins are a prominent class of pathogen recognition receptors in the innate immune system. The three pathogen recognition lectins studied in this thesis are the mannose binding protein (MBP), the dendritic cell-specific ICAM-3 grabbing nonintegrin (DC-SIGN) and the dendritic cell-specific …
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Mitochondrial Stress Signals Induce a Drug Tolerant Persister Phenotype in Triple Negative Breast Cancer Cell Models
… This innate immune activation takes place via pathogen recognition receptors (PRRs) that sense intracellular damaged self-DNA leading to heightened interferon production. Here, we explored the possibility of interferon induction downstream of mitochondrial damage as a novel DTP mechanism. For …
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Regulatory Mechanisms in Innate Immunity
… This process entails the cooperation among pathogen recognition receptors, adaptor proteins, kinases, and transcription factors that elicit the production of effector cytokines. As an important transcription factor, IRF5 was known to be essential for the host cytokine production in response …
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A study on human IFIT3 modulation of IFIT1 protein stability
… interferon-independent manners in cells after pathogen-associated molecular pattern recognition by the pathogen recognition receptors. Four IFITs (IFIT1, IFIT2, IFIT3 and IFIT5) have been identified and characterized in humans. They are cytoplasmic proteins with repetitive tetratricopeptide …
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Regulation of innate immune responses to Leishmania braziliensis infection
… Second, we demonstrated that interaction between pathogen recognition receptors and Lb parasites occurs both in vitro and in vivo, and that these interactions modify DC activation and infection outcome. We found that whereas the adaptor protein MyD88 was necessary for the establishment of a …
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The role of Dietary Interventions in Broiler Intestinal Health and Immunity
… response is characterised by the activation of pathogen recognition receptors upon recognition of microbial patterns. This action results in the activation of the transcription factor NF-κB, MAPK signalling pathways and the induction of pro-inflammatory cytokines. The gastrointestinal mucus …
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Microbiological, genomic and transcriptomic analyses of human tuberculosis lung cavities
… immunity in the lung remains poorly understood. Pathogenesis of pulmonary cavitation, the basis of TB transmission, is poorly understood. The degree of heteroresistance in the human lung remains unclear. METHODOLOGY: Multi- and extensively drug-resistant TB (MDR- and XDR-TB) patients scheduled …
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Exploration of Toll-like Receptor 7 and 8 Agonists as Potential Vaccine Adjuvants
Toll-like receptors (TLRs)-7/-8 are among pathogen recognition receptors (PRRs) present in the endosomal compartment that are activated by viral single-stranded RNA (ssRNA) as well as synthetic small molecules. TLR7/8 agonists hold promise as potential vaccine adjuvants, since they directly …
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Characterisation of a novel interaction partner for Atg16L1 and its role in regulating autophagy
… in response to starvation and to a surrogate pathogen. A novel interaction between Atg16L1 and the serine/threonine kinase MEKK4 has been characterised in this study. Existing research has established an interaction between the pathogen recognition receptors NOD1/2 and Atg16L1. The NOD …
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Role of proteases and chemokine receptors in a murine model of chronic obstructive pulmonary disease
… onderhouden door signalisatie via zogenaamde ‘pathogen recognition receptors’ (PRRs). Een verhoogde vrijstelling van proteinasen door inflammatoire cellen geeft dan weer aanleiding tot een onevenwicht tussen proteinasen en anti-proteinasen, dat bijdraagt tot de ontwikkeling van pulmonaal …
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Candida Albicans Als5p Amyloid In Host-Microbe Interactions: A Ceanorhabditis Elegans Study
… a dimorphic fungus and an opportunistic pathogen, possesses a myriad of adherence factors including members of the agglutinin-like sequence (Als) family of mannoproteins. The adhesin Als5p mediates adhesion to many substrates, and is upregulated during commensal interactions, but is …
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Role of Toll-like receptors in airway inflammation
Toll-like receptors (TLRs) are germline-encoded pathogen-recognition receptors that detect different microbial structures and activate the immune system. The human TLR family presently comprises ten members (TLR1-TLR10), each with distinct properties. Although the TLRs protect the host from …
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Intracellular triggering of inflammation by the extracellular bacterium Pseudomonas aeruginosa
… is an extracellular, Gram-negative opportunistic pathogen. One of the most important virulence factors during infection is the type III secretion system (T3SS). This system is found exclusively in Gram-negative bacteria and it forms a conduit between the bacteria and the host cell through which …
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The neonatal anti-viral response fails to control measles virus spread in neurons despite interferon-gamma expression and a Th1-like cytokine profile
… can cause CNS disease, the mechanisms of viral pathogenesis in the brain and the character of the neonatal anti-viral immune response are not well understood. However, it is hypothesized that neurological damage results from the combined effect of the virus and the immune response. Therefore, it …
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Evolutionary analysis of Suidae TLR signaling pathway
… the first line of host defense against pathogens. Toll-like receptors (TLRs) are the best characterized pathogen recognition receptors (PRRs) of the innate immune system. TLRs detect distinct pathogen associated molecules and engage downstream intracellular signaling cascades eventually …