Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"Pathogen Box"”.
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Exploring Protoheme IX Farnesyltransferase as an Antimalarial Drug Target
… interact with heme, as well as the 400-compound Pathogen Box collection from the Medicines for Malaria Venture (MMV). We identify a modest interaction of PfCOX10 with antimalarial DSM1, as well as several compounds from the MMV Pathogen Box. The data ultimately point to utility in further …
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Exploiting Chemical Libraries to Identify and Characterize Novel Bioactives with Efficacy Against Pathogenic Candida Species
… against Candida auris by leveraging the Pathogen Box library. Of the hits identified, the tri-substituted isoxazole MMV688766, was pursued and was classified as a disruptor of cellular lipid homeostasis. Secondly, I further investigated the mechanism of action of a hit molecule from the …
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Screening and Characterization of Antimicrobial Compounds and Material against Vibrio cholerae
… threat. With an increasing number of critical pathogens acquiring resistance against multiple classes of antibiotics, we face the terror of the post-antibiotic era. Vibrio cholerae, the cholera-causing pathogen, is no exception to the menace of multi-drug resistance. Strains from worldwide …
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Studying the biology of, and developing countermeasures to, a tick-transmitted hemorrhagic fever virus
… with outbreak case fatality rates up to 30%. Pathogenesis studies have focused on the later stages of disease, whereas little is known about the influence of the tick-vector in disease outcome. Herein, the role of tick-transmission of CCHFV was investigated to examine the biology and early …