Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 2652 for “"Pathogen"”.
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Pathogen Membrane Interactions
Unlike polyelectrolyte, amplipathic molecules interact with lipid membranes through electrostatic and hydrophobic interactions. Natural antimicrobial peptides and their synthetic derivatives are amphipathic molecules with broad-spectrum antimicrobial activity, but the underlying mechanism needs …
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Pathogen phylogenies for public health
… and apply methods to extract information from pathogen genome sequences via phylogenetic reconstructions. I extend existing phylogeny-based models to new applications in genome-wide association studies (GWAS) and genomic epidemiology. First, I show that correlations in an infectious disease …
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Actinomyces viscosus, a potential pathogen
Thesis (M.S.)--Michigan State University. Dept. of Microbiology and Public Health, 1974
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Computational investigation of pathogen evolution
Pathogen genomes, especially those of viruses, often change rapidly. Changes in pathogen genomes may have important functional implications, for example by altering adaptation to the host or conferring drug resistance. Accumulated genomic changes, many of which are functionally neutral, also serve …
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Genetically programmable pathogen sense and destroy/
… spp (shigellosis) and a variety of enteropathogenic Escherichia coli strains are among the principle bacterial agents that cause this type of diarrhea. Improvements in hygiene and access to adequate nutrition are good strategies but immunization against specific diseases still offers the …
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The host-pathogen interactions of Chinook Salmon (Oncorhynchus tshawytscha) and the aquatic rhabdoviral pathogen infectious hematopoietic necrosis virus
… Our goal was to define the unique host-pathogen interactions of Columbia River Basin Chinook salmon and their interactions with the two genogroups (U and M) of IHN viruses prevalent in the CRB to better understand the role that Chinook salmon may have in the ecology and epidemiology of …
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FUSARIUM MUSAE, A NEW POTENTIAL TRANSKINGDOM PATHOGEN.
… humans, animals, and the environment, enabling pathogens to evolve new survival strategies. In particular, the excessive application of fungicides both in agricultural and clinical settings not only contributes to the increase of fungal resistance but also complicates the treatment landscape for …
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Effects of temperature on wheat-pathogen interactions
… While direct effect of the environment on pathogen spread is often reported, effect of the environment on host defence is not. Many wheat resistance genes are temperature sensitive and these were used as a starting point to investigate defence temperature sensitivity in wheat starting with …
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Characterization of pathogen transport in overland flow
Overland transport kinetics of pathogens are controlled, in large part, by soil and vegetation. With an increasing number of concentrated animal operations, there is becoming a greater need to dispose of a vast amount of manure in a single, localized area. Animal manure contains a substantial …
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Cas protein diagnostics for pathogen nucleic acids
Cas protein diagnostics for pathogen nucleic acids - Akashaditya Das I formulated my research goals for my PhD in tandem with a Global Challenges Research Grant awarded to the Ajioka Lab in collaboration with other labs in the United Kingdom and South Africa. The grant aimed to develop tests for …
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Structure-Based Drug Design Against a Biosecurity Pathogen
… of new antibiotics against C. burnetii and other pathogens.<p></p>
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Iron and reactive oxygen in wheat-pathogen interactions
… proteins and pigments for both plants and pathogenic fungi. However, redox cycling between the ferric and ferrous forms of iron can also catalyse the production of dangerous free radicals and iron homeostasis is therefore tightly regulated. During pathogen attack, plants quickly produce …
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Systems Biology of Host-Pathogen Protein-Protein Interactions
… for a detailed understanding of SARS-CoV-2 pathogenesis. The angiotensin-converting enzyme (ACE2) receptor of SARS-CoV-2 is displayed on many human cells, including the lungs and other organs. However, despite considerable knowledge explaining the SARS-CoV-2 infection mechanism, …
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Pathogen Indicator Monitoring In The Ross Barnett Reservoir
… levels of bacteria in recreational waters, pathogen indicator monitoring is used. Sources of pathogens may include stormwater runoff, failing septic systems, lake-bottom sediments, and animals and humans in direct contact with the water. A collaborative study to investigate potential …
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Molecular analysis of the salmon pathogen Piscirickettsia salmonis
Piscirickettsia salmonis is the causative agent of Piscirickettsiosis, a disease causing significant losses in salmon aquaculture in Chile and which has also been isolated in salmonids in several other countries. This investigation was designed to prepare a recombinant library of P. salmonis DNA in …
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High sensitivity pathogen detection assays from crude samples
Detection of pathogens for diagnosis of disease is very important for advancing healthcare, especially in resource-scarce settings with minimal access to laboratory equipment or techniques. Culture being the gold standard for bacterial and fungal detection and immunoassay or nucleic acid-based …
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Host and pathogen genetics associated with pneumococcal meningitis
… The contribution of variation in host and pathogen genetics to pneumococcal meningitis is unknown. In this thesis I develop and apply statistical genetics techniques to identify genomic variation associated with the various stages of pneumococcal meningitis, including colonisation, invasion …
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Host-Pathogen Interactions at the Intestinal Epithelial Barrier
… to understand complex epithelial host-pathogen interactions a novel in vitro model of small intestine organoids was developed. Data suggest that immunoprotection against Eimeria vermiformis infections is mediated by T cells. Furthermore, there is an indication that ILCs have a …
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