Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 37 for “"Patho"”.
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Examining the (patho)physiology of physiologically relevant ligands present in the male and female reproductive tracts
… This study identified a novel homozygous pathogenic beta-defensin 128 (DEFB128) variant in one patient and demonstrated the expression of this protein on the sperm cell surface. The second novel male infertility gene proposed from this study is the MROH2B gene identified in one patient …
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Klinik und Pathologie des Epignathus : Literaturübersicht und Falldarstellung
… zum Epignathus, welche die genetischen, patho-anatomischen und patho-histologischen Grundlagen erfasst, die Darstellung bisheriger Therapieansätze, sowie die Darstellung und Dokumentation eines Kindes mit Epignathus welches im Jahre 2000 in der Klinik und Poliklinik für Mund-,Kiefer- und …
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DESIGN & DEVELOPMENT OF HETEROTOPIC TRANSCATHETER TRICUSPID VALVES TO AMELIORATE TRICUSPID REGURGITATION
… mock circulatory system (MCS) which emulated the patho-physiological pressure and flow conditions. Particle image velocimetry was used to study the flow characteristics in the MCS.
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Multifunctional soft robotic devices and cardiac benchtop models for improved therapy delivery and development
… and procedural training, and replicate (patho)physiological hemodynamics and motion. Taken together, this thesis research aims to create new therapeutic approaches that allow for patient-specific therapy delivery in response to each patient’s precise needs, and to support the development …
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Microfabricated Fibrotic Microtissue Array for Screening of Potential Anti-Fibrotic Treatments
… models can accurately recapitulate the dynamic patho-physiological changes in tissue mechanics during fibrogenesis. In this study, we created novel micropillar microdevices, which allow thin and membranous fibroblast microtissues to be formed, similar to the morphology of lung alveolar tissue. …
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Risk factors and Blood borne- biochemical markers in type 2 diabetes mellitus
… in diabetic research. Elucidation of common patho-physiological mechanisms among T2DM patients might emphasize the role of inflammation in CVD. The main purpose of this study was to investigate any patho-physiological changes in red blood cells (RBC), white blood cells (neutrophils and …
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Quantitative assessment of elasticity properties of skin using surface acoustic wave (SAW) method
… of skin that are useful for understanding skin patho-physiology, and aiding disease diagnosis and treatment. They are indicators of functional changes and pathological variations in the micro-structure. <br/><br/>This research thesis studies the intersection of acoustics, optics and biomechanics …
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Design of low complexity fault tolerance for life critical situation awareness systems
… and checking expected responses based on patho-physiological models. The proposed protocol organizes the medical information concisely and comprehensively to help medical staff validate treatments.The proposed protocol dynamically adapts to the patient conditions and side effects of …
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Quantitative Analyse der Aspiration bei trachealer Intubation an einem physikalischen Modell
… plazierten Tubus' spielt in bezug auf die Patho-genese einer VAP (Ventilator-associated-pneumonia) eine zentrale Rolle. Seine Falten sind es, die den Keimen als Weg in Richtung Lunge dienen, wo sie sich einnisten und für den Menschen schädlich werden können. <br>Diese Arbeit quantifiziert …
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Polyphosphate modulates hemostasis, thrombosis, and inflammation
… by activated platelets and is abundant in many pathogenic microorganisms. Our lab has recently shown that polyP from bacteria and human platelets play important roles in inflammation and coagulation in vitro and in vivo, supporting the paradigm of polyP as the long-sought (patho)physiologic …
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Korrelation von genetischen Polymorphismen mit dem Schweregrad der Intimahyperplasie nach Stentimplantation
… polymorphism has a significant influence on the patho-morphologically process of the instent restenosis. Smoking habits affect the neo intima hyperplasia at specific 4G/5G gene bearers. The result of this study shows an important example for an environmentally-genetically reciprocal action in the …
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Innovative microphysiological systems for long-term real-time imaging in biomedicine
… very basis of our capabilities i) to understand patho-physiological processes and ii) screen more effective and specific drugs based on their efficacy and toxicity. MPSs reform traditional in vitro cultures providing biological samples with artificial microenvironments aimed to induce …
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Modulation der neokortikalen Neurotransmission durch exogene und endogene Cannabinoide unter Berücksichtigung möglicher Speziesunterschiede zwischen Mensch und Tier
… Endocannabinoide (EC), denen man Bedeutung als (patho)-physiologische Neuromodulatoren beimisst. Die Manipulation des "EC-Systems" bietet einerseits therapeutische Möglichkeiten, kann aber auch zu unerwünschten Wirkungen auf Kognition und Gedächtnisleistung führen. Auf molekularer Ebene scheinen …
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A 3D in vitro model of the human gut-microbiome. A bioelectronics approach.
… of gut microbiota in various physiological and pathophysiological conditions, the mechanisms underlying the intricate cross-talk between the host and the intestinal flora remain a mystery. Until recently, the majority of studies that seek to explore these mechanisms relied almost exclusively on …
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Advanced glycation end product precursors in diabetes: a crucial link between oxidative stress and inflammation?
… and MG are pro-oxidant and pro-inflammatory at (patho)physiological concentrations in both monocytes and pancreatic β-cells.<br/><br/>In this work several new and important observations have been made regarding the action of α-dicarbonyls on oxidative stress and inflammation. 1) The amount of …
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Effect of Site-specific Changes in the Regulatory Functions of BosR
… provide insights into the role of BosR in the patho-physiology of B.burgdorferi.
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Role of CD4+CD25+ Regulatory T Lymphocytes in Experimental Toxoplasmosis
… only for achieving a better understanding of the patho-physiology of the disease, but also for developing better methods for evaluating new therapeutic regimens. The purpose of the present study was to investigate the role of CD4+CD25+ T regulatory lymphocytes in mice infected with <i>Toxoplasma …
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Application of Signal Advance Technology to Electrophysiology
… negative clinical consequences during various pathophysiological events. Reducing or eliminating such delays would increase the ability to provide successful early intervention in certain disorders thereby increasing the efficacy of treatment. In recent years, a physical phenomenon referred to …
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Computational fluid dynamics as aid tool for the management of aortic wall diseases
Aortic aneurysms and dissections are pathological conditions affecting the aorta. Despite being different in clinical presentation, these pathologies share a high mortality rate, as well as a lack of reliable prognostic predictors. Local fluid dynamics is assumed to play a role in aortic …
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