Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 10 of 10 for “"Paternal age"”.
-
Selfish Mutations: the Genetic Basis of the Paternal Age Effect
<p>As the mean age of childrearing grows, the effect of parental age on genetic disease and child health becomes ever more important. A number of autosomal dominant disorders show a dramatic paternal age effect due to selfish mutations: substitutions that grant spermatogonial stem cells (SSCs) a …
-
Associations of parental age, socioeconomic status, antral follicle count with assisted reproductive technology treatment outcomes
… issue. It is unclear whether advanced parental age, low socio-economic status (SES), and antral follicle count (AFC) are significantly and independently associated with adverse ART outcomes. There is little known about their interaction effects with an unhealthy lifestyle on adverse ART …
-
Parental Age at Conception: An Examination of Risk Factors Related to Autism Severity and Comorbid Psychopathology
… trend for parents to have children at later ages. Previous research has begun to examine the relationship between advanced parental age at conception and the incidence of autism and have noted strong relationships between advanced parental age and other developmental disabilities. The purpose …
-
ATM plays multiple roles in crossover regulation during mouse spermatogenesis
… aneuploidy—a major cause of infertility, miscarriage, and birth defects. In humans, approximately 1 in 20 sperm and 1 in 4 oocytes are aneuploid many from errors in crossover formation. My work focuses on understanding how the DNA damage response kinase Ataxia Telangiectasia Mutated (ATM) might …
-
A study of factors affecting the occurrence of down syndrome in Negeri Sembilan Malaysia
… the high correlation between advanced maternal age and the risk of Down syndrome, genetic and socio- demographic factors of population are expected to have considerable effect on Down syndrome births. The main objective of this research was to assess the effect of genetic and socio-demographic …
-
Labor, Delivery, and Neonatal Outcomes For Immigrant Women Versus Native-Born Women In Taiwan
… immigrant women (13% in 2006), who are, on average socio-economically disadvantaged relative to native-born Taiwanese women and are married to lower socioeconomic status Taiwanese men. Some countries have experienced an epidemiological paradox of better immigrant birth outcomes relative to …
-
A Search For Genetic Modifiers Responsible For Congenital Heart Disease Variability In The Presence Of Nkx2-5 Haploinsufficiency
… septal defects: VSD). Genome wide linkage analysis was conducted on 306 mice from the FVB/n F2 intercross and 80 mice from the A/J F2 intercross diagnosed with VSD to map main effect and interacting loci that correlate with risk. Additionally the possibility of environmental …
-
A Mother’s Hope: Pacific Teenage Pregnancy in New Zealand
… now an integral part of the cultural fabric. Teenage pregnancy (births, terminations and miscarriages of women <20 years) is a topic widely publicised over the decades. In the literature teenage pregnancy is associated with belonging to a minority population, being a solo parent, economic …
-
The effect of sperm apoptosis, Reactive Oxygen Species (ROS) and semen sample handling on sperm parameters and Assisted Reproductive Technology (ART) outcomes
… lower sperm motility, sperm count and advanced paternal age. No correlation was observed between sperm apoptosis and fertilisation rate, blastulation rate, day 5 embryo quality (D5EQ) and clinical pregnancy. Similarly, there was no correlation between sperm ROS levels and fertilisation rate and …
-
Molar pregnancy: A fifteen - year experience of a single tertiary institution
… because it affects women in the reproductive age group and is associated with morbidities and may sometimes be fatal (2). Molar pregnancy represents as two entities, complete or partial mole, which are mostly benign and can be distinguished by gross morphology, histopathology and genetic …