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Showing 1 to 9 of 9 for “"Pasteurella multocida toxin"”.
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Untersuchungen zur Struktur und Wirkung von Pasteurella multocida Toxin
Pasteurella multocida produziert ein 146 kDa Protein (PMT), das eine Vielzahl von zellulären Signaltransduktionswegen aktivieren kann. PMT ist ein starkes Mitogen, und führt zu vermehrter DNA-Synthese und Proliferation. Am besten untersucht ist die Aktivierung von Gaq durch PMT, die zu einer …
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Toxin-membrane interactions of Pasteurella multocida toxin and homologous domains
Toxin-membrane interactions are poorly understood on the molecular level due to the inherent difficulty of crystallizing membrane protein complexes and the large size (>50 kDa) of most functional AB or MARTX protein toxins. Toxins can interact with membranes at three stages during intoxication: 1) …
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Untersuchungen zur Wirkung des Pasteurella multocida Toxins auf die endotheliale Barrierefunktion in vitro
… Mechanismen zu erforschen, durch die das Pasteurella multocida Toxin zu einer Aktivierung von Endothelzellen mit anschließender Störung der Barrierefunktion des Endothels führt. Dafür wurden humane Endothelzellen (HUVEC) verwendet, die für Permeabilitätsmessungen auf Porenmembranen bis zur …
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Distinguishing delivery and catalytic activity differences among G-protein deamidating protein toxins of the cytotoxic necrotizing factor (CNF) and Pasteurella multocida toxin (PMT) family through comparative analyses
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2027-05-01
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Escape to the interior: Characterization of the cytosolic delivery of C-terminal cargo subdomains by the N-terminus of pasteurella multocida toxin and subsequent toxin-mediated downregulation of Gaq-PLCb1 signaling through depletion of Gaq from the plasma membrane
The bacterium Pasteurella multocida is a gram-negative, non-spore- forming, capsulated coccobacillus that lives an aerobic to facultative anaerobic lifestyle. P. multocida is a zoonotic pathogen that causes a myriad of diseases, including atrophic rhinitis, pasteurellosis, and dermonecrosis in a …
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Construction of CNFY-CNF1 Chimera Protein for Study of Differential pH Dependent Activity of CNF Proteins
… translocation into the cell. The CNF family of toxins is under the larger family of dermonecrotic AB toxins. These AB toxins have the ability to cause dermonecrosis when applied to the skin of animals. Among the dermonecrotic toxins, Pasteurella multocida toxin (PMT) and cytotoxic necrotizing …
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Application of NMR spectroscopy to interrogate the structures of bacterial protein toxin membrane localization domains and amphotericin B
… domains (MLD) of two different bacterial toxins. The MLDs studied were from the C-terminal domain of the AB toxin Pasteurella multocida toxin (PMT), which is expressed by Pasteurella multocida, and the Ras/Rap1-specific endopeptidase domain of the multifunctional autoprocessing …
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Investigation of the intracellular trafficking pathways of the dermonecrotic toxin family
… and trafficking pathways of the dermonecrotic toxin family composed of related AB toxins whose members induce dermonecrosis upon injection into animal skin. The dermonecrotic toxins Pasteurella multocida toxin (PMT) from Pasteurella multocida (P. multocida), cytotoxic necrotizing factors 1, 2, …
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Studies on the mode of action of dermonecrotic toxins: Effects on adipogenic signaling pathways and delivery of c-terminal cargo into the cytosol
The dermonecrotic toxin family consists of the dermonecrotic toxin from Bordetella spp. (DNT), the cytotoxic necrotizing factors from Escherichia coli (CNF1, CNF2 and CNF3) and Yersinia pseudotuberculosis (CNFY), and the mitogenic toxin from Pasteurella multocida (PMT). These relatively large …