Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 3 of 3 for “"Passive permeability"”.
-
Novel In-Vitro Approaches to Investigate Membrane Partitioning and pH-Dependent Passive Permeation of Small Molecule Drugs
Passive permeability of drug molecules through biological membranes is a fundamentally important process that involves the partitioning of molecules into the lipid bilayer membrane and passive permeation across the membrane. The majority of the drug molecules are either weak bases or acids. For …
-
De novo design of passively permeable cyclic peptides and incorporation of noncanonical amino acids to improve predicted binding affinity
… biologics. In ideal cases they combine the passive permeability and oral availability of small molecules with the binding specificity of larger biologics. However, achieving both of these features in a single designed cyclic peptide has remained elusive, with the majority of clinically …
-
Sodium and glucose transport across the in vitro perfused midgut of the blue crab, Callinectes sapidus Rathbun
… of the midgut in sodium balance. A reduction of passive permeability with salinity, however, was suggested. There was no measurable net sodium transport across the hindgut of the animal. The midgut of C. sapidus was also capable of net transmural glucose absorption. The net flux was considerably …