Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 47 for “"Parvalbumin"”.
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Age related changes and tissue distribution of parvalbumin in both normal and dystrophic 129 ReJ mice.
… this protease inhibitor has been identified as parvalbumin, a calcium binding protein. In this study, a polyclonal antibody raised in rabbits against normal mouse muscle parvalbumin (TPI) was used to study the concentration and tissue distribution of this protein in both normal and dystrophic …
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The Role of Parvalbumin Interneurons in Mouse Primary Visual Cortex during Visual Discrimination and Perceptual Learning
Parvalbumin-expressing (PV) cells are the most common class of inhibitory interneurons in the rodent cortex and play important roles in balancing cortical circuit activity and learning (Xu et al., 2010). PV cells are suggested to mediate feedforward inhibition and control gain modulation (Markram …
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Visual cortical plasticity : the role of parvalbumin expressing inhibitory neurons and abnormalities in models of neurodevelopmental disorders
… Here we evaluate the participation of parvalbumin-expressing (PV+) GABAergic neurons in two forms of experience-dependent modification of primary visual cortex (V1) in adult mice: ocular dominance (OD) plasticity resulting from monocular deprivation and stimulus-selective response …
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Molecular characterisation of parvalbumin and analysis of cross-reactivity in five fish species using sera from fish-allergic consumers and occupationally exposed workers
Parvalbumin, the fish major allergen, accounts for over 95% of clinical symptoms in allergic fish consumers. Importantly, this allergen displays lgE cross-reactivity thus allergic sufferers can exhibit clinical symptoms after the ingestion of non-sesitising fish species. In an occupational setting, …
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Classification of Neuronal Nicotinic Acetylcholine Receptors in Rat CA1 Hippocampal Interneuron Subpopulations Defined by Calcium-Binding Protein mRNA Expression
… proteins (CaBPs; calbindin, calretinin, parvalbumin) and eight nicotinic acetylcholine receptor (nAChR) subunits (alpha2-alpha5, alpha7, beta2-beta4) from interneurons from the stratum radiatum or stratum oriens within the CA1 region of rat hippocampi was analyzed using quantitative real …
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Role of serotonin2C receptor (5-HT2CR) in expression of cocaine-induced conditioned hyperactivity
… higher percentage of neurons expressing parvalbumin-IR also expressed 5-HT2CR-IR compared to other subpopulations. Since parvalbumin is located in GABA interneurons projecting to the cell body and initial segment of axon of pyramidal cells, these results raise the possibility that the …
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Genetic evaluation of walleye (Stizostedion vitreum vitreum) stock structure and recruitment in Claytor Lake, Virginia
… skeletal muscle malate dehydrogenase (MDH) and parvalbumin were identified (using starch and polyacrylamide gel electrophoresis techniques, respectively) for 217 walleyes from three Claytor Lake sites. MDH-B² allelic frequency was significantly higher in stocked than in unstacked cohorts. Muscle …
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Exploring the Behavioural Effects of Compound-21 Using Novel Object Recognition and Object in Place Tests in Long Evans Rats
… whether DREADD-mediated inhibition of parvalbumin (PV+) gamma-amino butyric acid (GABA)ergic interneurons of the medial prefrontal cortex (mPFC) would impair associative memory as measured by OiP. I showed that C21 did not affect either sex in NOR, or females in OiP. Male rats failed to …
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Charakterisierung der Expression von Synaptopodin in der postnatalen Entwicklung des Hippocampus
… Markerproteinen wie Calbindin, Calretinin und Parvalbumin durchgeführt. Dabei dienten Calbindin und Parvalbumin als Marker jeweiliger Untergruppen spineloser Interneurone, während Calretinin darüber hinaus auch in spinetragenden Interneuronen im Hilus und der CA3-Region des Hippocampus …
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Physiological Implications and Mechanisms of Estrogen Protection Associated With Myocardial Ischemia /Reperfusion Injury
… (OVX). Results indicated that (1) calbindin and parvalbumin are expressed in the adult rat heart (2) ovariectomy causes a loss of parvalbumin protein expression (3) these 'calcium buffer' genes do not show any clear, time dependent changes following CA/R. The effects of circulating plasma E2 on …
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Immunosensors developed on clathrate platform compounds
… These compounds were used for the inclusion of parvalbumin antibodies immobilised onto clathrate platform by incubation and were evaluated as immunosensors for fish species identification. The antibody/antigen binding event was evaluated using UV/Vis spectroscopy, electrochemical impedance …
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Interneuron networks and cortical dynamics : emulated whisking drives SOM interneurons in the ketamine anesthetized mouse SI neocortex
… of two major classes of interneurons (adapting Parvalbumin positive and facilitating Somatostatin positive interneurons) predominates during different phases of what corresponds to natural sensing cycles in a behaving rodent. These questions are addressed using an in vivo mouse model with …
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Role of GluN2C-containing NMDA Receptors in Cellular and Behavioral Deficits Associated with Corticothalamic Circuit Dysfunction in Schizophrenia
… deficits in GluN2C knockout mice including lower parvalbumin labeling and lower dendritic spine density, features similar to those observed in human condition. GluN2C heterozygous and knockout mice also exhibit behavioral and cognitive deficits relevant to schizophrenia. Moreover, a GluN2C/GluN2D …
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Cell-type specific cholinergic modulation of the cortex
… through its intimate interactions with parvalbumin-expressing and pyramidal neurons. Chapter 3 highlights astrocytes and their interactions with pyramidal neurons as important drives for stimulus-specific cortical plasticity during cholinergic modulation. This is one of the earliest …
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Understanding the role of striosomes in learning a decision-making task
… specifically reduced connectivity of inhibitory Parvalbumin (PV) interneurons on SPNs, is found in animal groups with lower learning ability. These results help elucidate the unclear role of striosomes in learning and provide ideas for future research directions that could inspire neurological …
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Neuroprotektive Funktion des Ciliary Neurotrophic Factor : Untersuchungen an CNTF-defizienten Mäusen nach Läsion der septohippokampalen Projektion
… synthetisierter CNTF beeinflußt axotomierte Parvalbumin-positive GABAerge septohippokampale Neurone nach Fimbria-Fornix-Durchtrenung substantiell und trägt zu deren postläsionalen Überleben bei. Dieser Effekt bleibt partiell auch nach langen Überlebenszeiten erhalten. (2) Die Abwesenheit des …
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Passive experience-dependent plasticity in mouse primary visual cortex
… synaptic plasticity, but also the engagement of parvalbumin-positive (PV+) inhibitory interneurons. Herein we build upon this foundational work and show that SRP expression can be explained as the engagement of two different interneuron subclasses: somatostatin-positive (SOM+) and PV+ cells. …
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Inhibition, Synapses, and Spike-Timing: Identification and disruption of pyramidal cell-interneuron interactions in SPW-Rs
… of pyramidal cell activity and ripple events to parvalbumin expressing neurons. We identified pyramidal cell-interneuron interactions during ripples, suggesting they serve as lateral inhibitors between cell assemblies. We additionally developed and implemented a novel neural device to explore the …
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Cerebral Organoids as 3-Dimensional Grafts in Traumatic Brain Injury
… produced organoids enriched for glutamatergic, parvalbumin, and somatostatin neurons. We demonstrate that in transplantation of organoids following traumatic brain injury, the organoid selectively integrates into the efferent motor cortex pathway, modulates forelimb motor recovery, and that …
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Auditory Processing Deficits in MSH2-KO mice are linked to Aberrant Inhibitory Neuron Function in the Thalamic Reticular Nucleus
… activity. We observed an increase in parvalbumin (PV<sup>+</sup>) expression, density, and cell area in the TRN, as well as high aggregation of the gap junction protein connexin-36 (Cx36). Cx36 is required for electrical coupling between TRN neurons, regulating the degree of synchrony …
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