Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 16 of 16 for “"Particle therapy."”.
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Applications of Voronoi partitions in particle therapy
Treating cancer using charged particles heavier than electrons is becoming more and more popular in modern cancer management due to its increased dose to the targeted tumors and improved sparing of surrounding normal tissues and critical structures. Many challenging and interesting mathematical …
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Treatment planning for manifold multi-ion particle therapy
Conventional charged particle radiation therapy systems utilise a single charged particle species to deliver a therapeutic radiation dose to the target - most commonly protons or carbon ions. While such radiation therapy is highly effective for the treatment of many cancers, there is growing …
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High-Throughput Mapping of The Biological Effects of Particle Therapy
<p>Radiation therapy is an essential tool in the cure of many cancer patients. Charged particle based radiation therapies are gaining momentum as the physical dose distributions of ions are superior to standard photons due their limited range. Additionally, charged particle radiation has been shown …
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Pre-clinical evaluation of lethal and sublethal DNA damage in human cell cultures by ultrashort pulse and ultra-high dose rate laser accelerated protons
Particle therapy has been cited as an effective treatment modality, compared to photons and electrons-based therapies for solid tumors located in close proximity to critical organs, such as spinal cord, brain and heart. Numerous studies have demonstrated the feasibility of using high LET particles …
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Simulation, design and construction of a gas electron multiplier for particle tracking
The biological effects of charged particles is of interest in particle therapy, radiation protection and space radiation science and known to be dependent on both absorbed dose and radiation quality or LET. Microdosimetry is a technique which uses a tissue equivalent gas to simulate microscopic …
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Overcoming radioresistance by targeting p21 in cancer
Radiation therapy is one of the most effective cytotoxic therapies to treat localized solid cancers, with external beam radiation and brachytherapy being the most used approach in clinical practice. Proton and charged particle therapy represents a promising advancement in the field, allowing for …
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Building a Hybrid Compton Camera System for Improving Medical Imaging Applications
… methods for medical applications such as proton therapy and other targeted radiotherapies. Unlike mechanically collimated imaging systems, a two-stage Compton camera uses a combination of scatterer and absorber detectors to reconstruct gamma-ray paths through Compton scattering events, allowing …
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Development of A Remote Dosimetric Audit Framework For Carbon Therapy
<p>Carbon ion therapy is available at over a dozen institutions around the world and is being employed for treatment of cancer. The increased biological effect of carbon compared to conventional photon-based radiotherapy holds promise for the therapeutic benefit in historically radioresistant …
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Robust and efficient methods for proton computed tomography.
… alternative to X-ray CT for planning proton therapy treatments. There are several conditions in pCT that can negatively affect the accuracy of pCT images. The goal of this dissertation is developing efficient image reconstruction methods generating accurate RSP values under both normal and …
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Development and Evaluation of Novel Anti-HER2 Theranostics Against HER2-Positive Breast Cancer
… as radioimmunotherapies (using beta and alpha particles-based agents), immune checkpoint inhibitors, and vaccines and combinations of these with standards of care are active areas of research. The overall hypothesis of the thesis is that safe and more effective anti-HER2 theranostics can …
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Design and implementation of the Hybrid Detector for Microdosimetry (HDM): Challenges in readout architecture and experimental results
… 30 years, clinical results have shown that ion therapy may be a superior treatment option for several types of cancer, including recurrent cancers, compared to conventional radiation. Despite these promising results, there are still several treatment uncertainties related to biological and …