Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"Paroxetine"”.
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Analysis of rat brain lipids and metabolites after antidepressant drug treatment
… and the selective serotonin re-uptake inhibitor paroxetine. The effects of the drugs in rat brain regions implicated in depression: the prefrontal cortex (PFC), hippocampus (HP) and striatum (ST) were investigated both acutely (single administration) and chronically (daily treatment for 15 days). …
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Biotransformaciones en la síntesis y resolución de compuestos de interés farmacéutico
… key intermediates in the synthesis of (-)-paroxetine", j. Org. Chem, 2001, 66, 8947-8953. M. Bayod, v.m. Sánchez, v. Gotor, r. Brieva, g.de gonzalo, "precursores ópticamente puros de paroxetina", es patent 2001101648, 2001; "optically pure paroxetine precursors", eur. Patent 1,283,200 …
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Gene discovery: Polymorphism association with obsessive-compulsive disorder and proteome analysis of Artemisia annua.
… affect the efficacy of venlafaxine and paroxetine treatment in OCD. The response in paroxetine treated patients is associated with the GG genotype of the 5-HT2A polymorphism (χ2 = 8.66, df=2, p=0.013). In venlafaxine treated patients, response is associated with the SL genotype of the …
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Prediction of In-Vivo Antimuscarinic Activity (AMA) by In-Vitro Receptor Binding Assessment and PK/PD Modeling For Prototypical Drugs
… Prototypical drugs olanzapine, diphenhydramine, paroxetine were selected for the analysis. Scopolamine and darifenacin were included as positive and negative controls, respectively. Physiochemical properties, pharmacokinetic data, and clinical incidence of AMAEs for the selected drugs were …
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Who Gets Better and Why? Predicting the Development of a Working Alliance and its Subsequent Role in Pharmacotherapy for Social Anxiety Disorder
… with the selective serotonin reuptake inhibitor paroxetine. Higher levels of depression predicted higher levels of social anxiety symptoms at the end of treatment and higher levels of submissive behavior and childhood emotional maltreatment predicted a higher probability of attrition from …
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Novel palladium precatalysts and their application in cross- coupling reactions and copper-catalyzed enantioselective ring formation
… in the enantioselective synthesis of paroxetine.
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Synthesis And Evaluation Of Novel Tropane Compounds As Potential Therapeutics For Drug Abuse
… their binding affinities were equipotent with paroxetine and fluoxetine (Prozac). A series of 8-azabicyclo[3.2.1]oct-2-ene derivatives were synthesized from 3-tropinone based on the structure of triple re-uptake inhibitor, DOV 216, 303. The compounds were designed as potential triple re-uptake …
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EFFECTS OF SIGMA-1 RECEPTOR AGONISTS ON COMPULSIVE BEHAVIOR AND NEUROPLASTICITY
… and the serotonin reuptake inhibitor paroxetine significantly reduced marbles buried, but did not affect response latency in the novelty suppressed feeding test. Only fluvoxamine exhibited reduced marbles buried up to 72 hrs post treatment. Dextromethorphan did not affect levels of …
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The Relationship of Testosterone and 5-HT to Aggressive, Self-Aggressive, and Antisocial Behavior in Men
… interview were also administered placebo or paroxetine. Cortisol, free and total testosterone, and 5-HT activity were measured by assaying serum samples via venipuncture at four time points. Results showed that cortisol was negatively correlated with antisocial behavior and that blunted …
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ROLES OF MAST CELL G PROTEIN-COUPLED RECEPTOR KINASE 2 (GRK2) IN ALLERGY AND INFLAMMATION
… and degranulation. GRK2 inhibitors (paroxetine and its analog CCG258747) inhibited FcεRI-induced calcium mobilization and degranulation, and their intravenous administration in mice resulted in substantial reduction of IgE-mediated anaphylaxis. However, both compounds induced calcium …
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Pharmacotherapy for Social Anxiety Disorder and Posttraumatic Stress Disorder: New Meta-Analytic Approaches to Synthesising the Evidence
… aim one. For aim three (the SAD NMA), the SSRI paroxetine was significantly more effective than placebo in reducing the number of responders (odds ratio (OR) 2.64; CI 1.97 to 3.54) and anxiety symptoms (mean difference (MD) -15.89; CI -29.94 to -1.84) yet performed worse in comparison to placebo …
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INAPPROPRIATE ANTICHOLINERGIC MEDICATION USE IN ELDERLY PATIENTS
… to be oxybutynin (4.54%), solifenacin (4.48%), paroxetine (2.81%), tolterodine (2.47%) and promethazine (2.41%). Of the predisposing factors, the odds of receiving inappropriate anticholinergic drugs in elderly dementia patients were significantly lower for patients between 75 - 84 years of age …