Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"Parkinsons disease"”.
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Predictive Modeling of Early Stage Parkinsons Disease
… Early stage (preclinical) detection of Parkinsons disease (PD) remains challenged yet is crucial to both differentiate it from other disorders and facilitate timely administration of neuroprotective treatment as it becomes available. Objective: In a cross-validation paradigm, dual binary …
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Validation of KLK-6 as a New Therapeutic Target for Parkinsons Disease
Η α-συνουκλεΐνη (α-Syn) αποτελεί μια προσυναπτική νευρωνική πρωτεΐνη που εμπλέκεται γενετικά και βιοχημικά σε μια ομάδα νευροεκφυλιστικών νοσημάτων γνωστών ως συνουκλεϊνοπάθειες. Παθολογικές μορφές της α-Syn έχουν συσχετιστεί με την ανάπτυξη της νόσου Πάρκινσον (PD), ενώ έχει αποδειχθεί ότι …
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Investigations into the Neuroprotective Effects of Osteopontin in In Vitro and In Vivo Models of Parkinsons Disease
… neurons in the SN (SN) in Parkinson’s disease (PD). OPN prevents the death of dopaminergic neurons in cell culture and animal models of PD. This effect may be mediated through interactions between the RGD binding domain of OPN and integrin receptors resulting in an attenuation of …
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The Effects of Interpersonal Variables and Dance on the Well-Being of Informal Caregivers
… caregivers. In Study 1, 20 couples coping with Parkinsons disease (PD) were surveyed about their attitudes toward their partners, in general, and also within a Dancing with Parkinsons (DwP) class. Appreciation for ones partner was associated with greater relationship satisfaction, and when care …
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Chronic Monitoring and Longitudinal Efficacy of Neuromodulation for Neurological Movement Disorders
… to effectively manage the symptoms of a disease while also providing an understanding of the progression of neurological disorders. I design and implement a framework for monitoring the long-term effectiveness of deep brain stimulation. Using this framework we compare several aDBS …
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Short- and Long-Term Changes in Attention, Memory and Brain Activity Following Exercise, Motor Learning, and Expertise
… clinical populations, including people with Parkinsons disease.
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Thermodynamic Characterisation of Amyloid Fibrils
Amyloid fibril related diseases include dementia, Alzheimer’s disease and Parkinsons disease and pose an increasingly large burden to global healthcare, due to the presence of an ageing population. Despite many healthcare advances, amyloid fibril diseases remain largely untreatable, with only …
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ELUCIDATION OF MECHANISMS GENERATING 5-HYDROXYMETHYLCYTOSINE (5hmC) IN MAMMALIAN MITOCHONDRIA
… mitochondrial function and changes that occur in diseases involving mitochondrial dysfunction such as ischemic heart disease, neurodegenerative diseases like Parkinsons disease, and cancer.</p>
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Transformational Educational Leader as Organizer and Administrator of a Movement Disorders Program
One person in every thousand develops Parkinson's Disease. There is no known cause, no known cure and no existing definitive test for Parkinson's Disease. Qualified neurologists and movement disorders specialists make a diagnosis on the basis of their knowledgeable observations. If a cause is …
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Studies in the handling and absorption of biopterin derivatives in man
… altered tissue/body fluid partition. In kidney disease, where urinary concentration is impaired, urinary levels were extremely low and serum levels significantly elevated. Low serum values were found in leukaemia, pernicious anaemia, psoriasis, myeloma, regional enteritis and rheumatoid …
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Generation of midbrain dopaminergic neurons in vivo and in vitro: the role of Neurogenin2
Parkinsons disease (PD) is a neurodegenerative disorder where dopaminergic neurons of the substantia nigra (SNc) in the mesencephalon are progressively eliminated. The ensuing loss of dopaminergic innervation of the basal ganglia manifests itself as severe motor deficits in PD patients. Clinical …
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The Perceived Effects of Dance for Individuals with Parkinson’s Disease and Healthy Amateurs
… groups of dancers: dancers with Parkinson's disease (PD) and healthy amateur (HA) dancers. Dancers in the Parkinson's sample group were gathered from participants in the Dance for PD® program, while healthy amateur dancers were recruited from university dance departments and through social …
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Investigating Parkinson’s Disease human iPSC-derived models through single-cell gene expression
… still under active development for clinical and disease modeling purposes. Directed differentiation protocols of iPSC to midbrain dopaminergic neurons enables the study human midbrain Dopamine(DA) neurons, the primary neuronal group affected in Parkinson's Disease(PD), in-vitro. Despite their …