Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 199 for “"Parkinson’s Disease (PD)"”.
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Ethical, Legal and Social/Societal Implications (ELSI) of Recall-by-Genotype (RbG) approaches in the Cooperative Health Research in South Tyrol (CHRIS) study on genetic risk factors of Parkinson’s disease (PD)
… studies (RbG1, RbG2) on genetic risk factors of Parkinson's disease (PD). We used various qualitative and quantitative methods, including in-terviews, surveys and focus group discussions (FGD). Thereby, we sought to address the need for qualitative data from diverse stake-holders, including …
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Nanotechnology based therapeutic approaches to iron‐induced oxidative stress in an in vitro model of Parkinson’s disease
In Parkinson’s disease (PD), excess free iron drives the accumulation of toxic hydroxyl radicals within mitochondria of dopaminergic neurons, resulting in sustained oxidative stress and cellular damage. The blood‐brain barrier (BBB) prevents most pharmaceuticals from entering the brain, therefore, …
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Signatures of gut microbes in human diseases
… as contributing factors in a wide range of human diseases. This work investigates how bacteria residing in the human large intestine – home to the densest microbial community in the body – contribute to the pathogenesis of three distinct conditions: Parkinson’s disease (PD), inflammatory bowel …
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The Role of Advanced Glycation End Products (AGEs) through the TRPA-1/NRF-2 Activation Pathway in the Neurodegenerative Diseases
… is associated with various age-related diseases including diabetic complications and neurodegenerative diseases. Aging and long-term hyperglycemia causes enhanced production of this highly reactive α-dicarbonyl, which reacts with macromolecules causing irreversible damage of DNA and …
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Effect of Levodopa on EEG Connectivity in Parkinson's Patients
… medication administered to patients with Parkinson’s disease (PD) to alleviate their motor symptoms. However, its long-term use can cause adverse side effects, including involuntary motor movements. We studied 16 PD patients before and after taking Levodopa based on resting-state …
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Brain-derived Extracellular vesicles as biomarkers of Parkinson’s disease
Parkinson’s Disease (PD) is a common neurodegenerative disease that is projected to increase in prevalence with the aging population. Current diagnosis of PD is based on clinical criteria as there exists no objective biomarker capable of diagnosing the disease. Clinical trials into protein …
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An Investigation of the Clinical Predictors of Impulse Control Disorders in Patients with Parkinson's Disease
A sub-group of patients with Parkinson’s disease (PD) experience impulse control disorders (ICD), which can result in serious negative consequences. Although clarifying the risk factors of ICD can inform tailored intervention strategies, the clinical predictors of ICD are poorly understood. The …
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The Effects of Dance on Motor and Non-Motor Functions, and Resting State Electroencephalography in Individuals With Parkinson's Disease and Age-Matched Controls
… the effects of a single Dancing with Parkinson’s (DwP) class on behavior (balance, walking speed, depression) and electroencephalography (resting state - rsEEG) in individuals with Parkinson’s disease (PD) and age-matched controls (CONs). Following a single 75-minute DwP class, …
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Identifying Motivators, Facilitators, and Barriers to Engaging in an Online Fine Motor Exercise Program
… facilitators and barriers for individuals with Parkinson’s Disease (PD) in engaging in a fine motor exercise program given online. Methods: Using a phenomenological design, a purposive sample of 6 individuals with PD were recruited. Data were collected through semi-structured interviews via zoom …
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Verb Use in Parkinson's Disease
… are well documented in persons with Parkinson’s disease (PD). The grammatical and the motor theories have been proposed as possible explanations for verb impairments. The purpose of this study is to describe the use of low-motion and high-motion content verbs in PD in everyday …
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Parkinson's Patients' Upper and Lower Limb Motor Impairments Differentially Influence Action Verb Processing
… present study investigates whether patients with Parkinson’s disease (PD) who have greater upper versus greater lower limb impairments show different patterns of performance when processing action verbs. Patients and matched controls made action decisions on upper-limb (reach), lower-limb (kick), …
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MRI microstructure and morphology enable machine learning-based prediction of freezing of gait in Parkinson’s disease.
Freezing of gait (FOG) in Parkinson’s disease (PD) is a debilitating, often treatment-resistant symptom impairing mobility and quality of life. Early identification of high-risk patients may enable targeted intervention, yet few prognostic biomarkers exist. In this thesis, we developed a machine …
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Effects of Practice on Learning and Retention of Tool-Related Motor Skills in Parkinson's Disease
Previous research revealed that individuals with Parkinson’s disease (PD) show preserved learning of tool-related motor skills within a session. However, as a possible result of striatal dysfunction, retention has been found to be impaired after a 3-week delay. The goal of the current study was to …
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"Towards Closed-Loop Sleep Monitoring in Parkinson’s Disease: Self-Supervised Learning Strategies for Sleep Stage Classification"
Parkinson’s disease (PD) involves severe sleep disturbances that may accelerate neurodegeneration. Closed-loop deep brain stimulation (DBS) is a promising therapeutic solution but requires accurate, real-time sleep-stage classification from subthalamic nucleus signals, a task where conventional …
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AUTOANTIGENS IN PARKINSON'S DISEASE
Parkinson’s disease (PD) is a debilitating movement disorder characterized by the loss of dopaminergic neurons in the substantia nigra. Little is known about the role of autoimmunity in PD pathogenesis. This thesis examines the role of two autoantigens, α-synuclein and the stress inducible …
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Sex and LRRK2 Genotype Differences in Inflammation and Dopaminergic Neurodegeneration in a Multi-Hit Model of Parkinson's Disease
Parkinson’s disease (PD) is a multifactorial condition precipitated by environmental insults in conjunction with genetic vulnerabilities, sex differences, and aging. The objective of the current thesis was to explicate potential additive/synergistic effects of genetic LRRK2 anomalies and …
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Visual Computing and AI Technologies to Analyse Movement Disorders Associated with Parkinson’s Disease for Diagnostic Purposes
Clinical assessments of Parkinson’s disease (PD) centre on clinicians’ inherently subjective visual interpretations of characteristic motor signs like bradykinesia. This research investigates comprehensive video and signal processing techniques and their capacity to yield clinically meaningful …
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Perceptual Organization in Parkinson’s Disease: A Behavioral Investigation of Basal Ganglia Dysfunction
… as seen in neurodegenerative disorders like Parkinson’s disease (PD). Well known tests of visual perception in PD “explicitly” measure object recognition (a high-level visual process) but “implicitly” rely on intact mid-level visual processes like grouping and figure-ground segmentation to …
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Drp1 inhibition is protective against mitochondrial and autophagic impairment induced by alpha-synuclein
Parkinson’s disease (PD) is the second most common neurodegenerative disorder with currently no effective neuroprotective or neurorestorative treatments available. Alpha-synuclein (α-syn) pathology is one of the key proteins involved in PD pathology, it has been found to induce mitochondrial …
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Cell model of DJ-1-associated Parkinson’s Disease
Parkinson’s disease (PD) is a neurodegenerative disorder characterized by progressive loss of motor function resulting from dopaminergic neuronal death in the substantia nigra pars compacta leading to subsequent decreased striatal dopamine levels. The majority of PD cases are diagnosed as sporadic …
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