Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 431 for “"Parkinson’s Disease"”.
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Genetic determinants of cognitive heterogeneity in Parkinson’s disease
People with Parkinson’s disease (PD) display an increased rate of cognitive decline heterogeneous in its presentation and detrimental to a person’s quality of life. The causes of cognitive diversity are unclear, however exploration of the genetic contribution to cognitive profiles is unearthing …
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Pacemaking Neurons in the study of Parkinson’s Disease
Parkinson’s disease is the second most common neurodegenerative disorder with a signiVcant social cost. The disease that develops over years results in signiVcant movement related problems for the aUected. The pathogenesis however is partially understood. Computational approaches are signiVcant in …
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Cell model of DJ-1-associated Parkinson’s Disease
Parkinson’s disease (PD) is a neurodegenerative disorder characterized by progressive loss of motor function resulting from dopaminergic neuronal death in the substantia nigra pars compacta leading to subsequent decreased striatal dopamine levels. The majority of PD cases are diagnosed as sporadic …
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Ethno-Racial Background and Risk for Parkinson’s Disease
Parkinson’s disease is the second-most common progressive neurodegenerative disorder in the world. Presently, there is a lack of evidence from large-scale multifactorial studies suggesting a definitive link between race/ethnicity and PD risk. In our research, we conducted a targeted literature …
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Genetic correction of Parkinson’s disease using CRISPR-SKIP
Parkinson’s Disease (PD) is the second most common neurodegenerative disease after Alzheimer’s disease. It affects 1-2% of the total world population with more than 500,000 patients in the US. PD is a progressive disorder that selectively affects the dopaminergic neurons in the substantia nigra of …
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Brain-derived Extracellular vesicles as biomarkers of Parkinson’s disease
Parkinson’s Disease (PD) is a common neurodegenerative disease that is projected to increase in prevalence with the aging population. Current diagnosis of PD is based on clinical criteria as there exists no objective biomarker capable of diagnosing the disease. Clinical trials into protein …
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α-Synuclein phosphorylation and related kinases in Parkinson’s disease
Parkinson's disease (PD) is the most common neurodegenerative movement disorder pathologically identified by degeneration of the nigrostriatal system and the presence of Lewy bodies (LBs) and neurites, structural pathologies largely made from insoluble α-synuclein phosphorylated at serine 129 …
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Vision in Parkinson’s disease: more than meets the eye
Contains fulltext : 288679.pdf (Publisher’s version ) (Open Access)
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VGF: a novel and predictive biomarker of Parkinson’s disease
Parkinson’s disease (PD) is a progressive neurodegenerative disorder characterized by a prodromal phase in which non-motor symptoms precede the onset of classical motor impairments. Identifying reliable biomarkers capable of detecting PD during these early stages remains a major clinical challenge. …
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Derivation of next generation research models of Parkinson’s disease
Parkinson's disease (PD) is the second most common neurodegenerative disorder following Alzheimer's disease. PD is characterized by the degeneration of dopaminergic neurons in the substantia nigra region of the midbrain and the presence of intracellular inclusions, notably Lewy bodies composed of …
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Clinical Assessment and Management of Balance Impairments in Parkinson’s disease
Contains fulltext : 250218.pdf (Publisher’s version ) (Open Access)
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DJ-1 AND ATP13A2: TWO PROTEINS INVOLVED IN PARKINSON’S DISEASE
<p>Parkinson's disease (PD) is the second most common neurodegenerative disorder after Alzheimer's disease, affecting approximately 0.3% of the total U.S. population, and its prevalence increases with age. Two neuropathological hallmarks of PD are the loss of dopaminergic neurons in the …
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Pathobiology of neuroinflammation and basal ganglia circuitry in Parkinson’s Disease
Parkinson’s disease (PD) is the second most common neurodegenerative disease worldwide and the most common movement disorder. A defining pathologic feature of PD is the progressive death of dopaminergic neurons in a basal ganglia nucleus termed the substantia nigra (SN). Another hallmark feature of …
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The Effects of Socioeconomic Status on the Progression of Parkinson’s Disease
The effects of socioeconomic status (SES) on Parkinson’s disease (PD) have not been widely studied, and the effects of SES on PD progression remain unknown. To understand this relationship, we conducted a medical record chart review of PD patients at Wake Forest Baptist Medical Center (WFBMC). The …
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Advancing understanding of endogenous PINK1-Parkin signalling linked to Parkinson’s disease
Parkinson’s disease (PD) is the second most common neurodegenerative disorder. Discoveries of heritable, disease associated mutations in multiple genes has linked mitochondrial dysfunction with PD. Two of these gene products, PINK1 and Parkin, function together in a common pathway. The PINK1 kinase …
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THE EFFECTS OF PARKINSON’S DISEASE AND ASSOCIATED TREATMENTS ON SACCADIC EYE MOVEMENTS
… reason, eye movements have been used to study Parkinson’s disease in order to bypass the distal limb motor deficits seen with disease progression. This study aimed to use eye movements to correlate disease severity with performance on a battery of cognitive tasks, and ultimately elucidate some …
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Towards a quantitative assessment of early-stage Parkinson’s disease using BioVRSea paradigm
Neurodegenerative diseases (NDDs) are considered one of the twenty-first century most pressing public health issues. One consistent risk factor for developing NDD is increasing age and the increased longevity of the world population results in the rise of NDDs. Parkinson's disease (PD) is the …
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