Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 18 of 18 for “"Parkinson`s disease"”.
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Dementia in Parkinson s Disease: relationship between clinical and neurobiological aspects
… più comuni e importanti della malattia di Parkinson (PD), influisce notevolmente la qualità e l aspettativa di vita del paziente. Lo spettro delle disfunzioni cognitive nei PD è stato recentemente codificato in termini di Mild Cognitive Impairment (PD-MCI) e Demenza (PDD) con criteri …
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MODELLING GBA1-RELATED PARKINSON¿S DISEASE PATHOLOGY IN PATIENT-DERIVED MIDBRAIN ORGANOIDS
… are the key neuropathological hallmarks of Parkinson’s disease. Mutations in GBA1, encoding the glucosylceramide-hydrolyzing enzyme glucocerebrosidase, cause Gaucher’s disease and are the most frequent genetic risk factor for Parkinson’s disease. However, a defined link between mutations in …
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LEUCINE-RICH REPEAT KINASE 2 (LRRK2) AT THE CROSSROAD OF INSULIN SIGNALLING AND PARKINSON S DISEASE
… the most important genetic risk factors for Parkinson’s Disease (PD). Recent evidence suggests a link between PD development and defective insulin signalling, but the reason is still unknown. Interestingly, besides being expressed in the CNS, LRRK2 plays a crucial role also in the periphery. …
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Structure and dynamics of the aggregation mechanism of the Parkinson´s disease-associated protein alpha-synuclein
Die Parkinson-Krankheit ist eine der häufigsten degenerativen Erkrankungen des Gehirns mit Steifheit der Muskulatur, Zittern und Verlangsamung der Bewegung als typischen Symptomen. Im Verlauf der Krankheit kommt es zum Verlust von dopaminhaltigen Nervenzellen und proteinhaltigen Ablagerungen in der …
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The role of copper in Parkinson's disease
… reported in the degenerating substantia nigra in Parkinson s disease, but the cause, and functional consequences, of this decrease are unknown. This thesis aimed to investigate neuronal copper levels and potential changes in copper transport in the Parkinson s disease brain to determine if altered …
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Investigation of FAD Chemical Models to Study the Monoamine Oxidase Catalyzed Oxidation of Cyclic Tertiary-Allylamines
… (TMMP), which is a close analog of the parkinsonian-inducing designer drug 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). MAO-B catalyzes the conversion of MPTP and its derivatives into active neurotoxins in the brain that subsequently mediate neurogenerative processes that mimic …
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Gait Disorders in Parkinson's disease: pharmacological and non-pharmacological approaches
… deficits are common and debilitating features of Parkinson s disease (PD). Many pharmacological and non-pharmacological therapies have been proposed to improve gait in PD patients. Adequate and timely recognition of balance and gait disorders is important to identify patients at risk of falling. …
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Engrailed genes are cell autonomously required for the survival of the mesencephalic dopaminergic neurons
… most prominent human neurodegenerative disorder, Parkinson´s Disease. Accumulating evidence suggest that these neurons die by apoptosis in afflicted patients. Still little is known about the molecular mechanisms that lead to full differentiation and maintenance of these neurons. This neuronal …
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REDOX PROTEOMICS, THIOL HOMEOSTASIS AND NEUROPHYSIOLOGICAL CORRELATIONS IN AGING AND NEURODEGENERATION
… in the aging processes and neurodegenerative diseases. Within the frame of free radical hypothesis of aging, several lines of evidence suggest that accumulation of oxidative molecular damage is a causal factor in senescence. It is also increasingly evident that the mitochondrial genome may …
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Validación de la nueva versión de la escala unificada para la evaluación de la enfermedad de Parkinson (MDS-UPDRS) en español. Resultados de la fase I : (validación lingüística)
La enfermedad de Parkinson es el segundo trastorno neurodegenerativo más frecuente, afectando del 1 al 2% de las personas mayores de 60 años a nivel mundial.(1) No hay un test diagnóstico ni un marcador clínico confiable y fácilmente aplicable para el diagnóstico de ésta enfermedad así como tampoco …
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Investigating neuronal mitochondrial DNA loss in Drosophila melanogaster
… cause neurodegeneration and has been linked to Parkinson‟s disease. However, the pathological consequences of mtDNA loss in neurons are very poorly understood.<br/><br/>We have used the fruitfly, Drosophila melanogaster, to study how loss of mtDNA affects neuronal function. We find that both …
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Transient receptor potential vanilloid 1 exhibits neuroprotective effects in LPS-induced dopaminergic neuronal death in the suabstantia nigra in vivo.
Parkinson？s disease (PD) is a motor disorder which is progressive degeneration of the nigrostriatal dopaminergic pathway. There is no cure for PD and besides the etiology of this disease was limited understood. Neuroinflammation have been proposed to play a role in the pathogenesis of PD. Recent …
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Progress Towards Development Of Multifunctional, Dopamine D2/d3 Receptor Agonists As Symptomatic And Disease-Modifying Therapeutic Agents For Parkinson's Disease
<p>Parkinson¡¯s disease (PD) is a progressive, neurodegenerative disorder that arises primarily through the loss of dopaminergic neurons in the substantia nigra pars compacta (SNc), resulting in a diminished level of the neurotransmitter dopamine in the nigrostriatal pathway and ensuing loss of …
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Protective effects of Human Bone Marrow-Derived Mesenchymal Stem Cells on Apoptosis Induced Human Neuroblastoma SH-SY5Y Cells
… of neurological disorders including Alzheimer…s disease, Parkinson…s disease and stroke. Cell therapy using human bone marrow-derived mesenchymal stem cells (hMSCs) is an attractive tool to alleviate neurological disease We investigate whether culture media of hMSCs and coculted hMSC using by …
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Methionine Sulfoxide Reductase and Ubiquitin-dependent Degradation of Alpha-synuclein
… to be involved in the pathogenesis of the Parkinson`s disease (PD) and being the main component of Lewy bodies (LBs). Studies on the αSyn gene mutants and overexpression of αSyn in yeast and rodent brains indicate that the level of αSyn in neurons is linked to dopaminergic neurons …
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ACTING AS THERAPEUTIC SUPPORT IN PARKINSON'S DISEASE. A FIELD EXPERIMENT
In passato l'approccio clinico alla malattia di Parkinson si concentrava essenzialmente sulla sintomatologia motoria: l'attuale tendenza invece sottolinea l'importanza dei sintomi non motori e pertanto si orienta verso un tipo di assistenza più complessa, tesa a potenziare le capacità residue di …
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Study on the Neuroprotective Effects of Ethyl pyurvate in MPTP-induced Mouse PD Models
… (MPTP) mouse model of Parkinson’s disease. MPTP induced degeneration of nigrostriatal DA neurons and glial activation as visualized by tyrosine hydroxylase, macrophage antigen complex-1, and/or glial fibrillary acidic protein immunoreactivity. Western blotting and …
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Neuroprotektion und Neurorestauration im MPTP Modell der Parkinson Erkrankung
Parkinson ist die häufigste neurodegenerative Erkrankung der Basal Ganglien und ist charakterisiert durch den progressiven Verlust dopaminerger Neurone in der substantia nigra pars compacta (SNpc). Der glial cell line-derived neurotrophic factor (GDNF) ist in präklinischen Studien als wichtiger …