Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 437 for “"Parkinson's disease"”.
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AUTOANTIGENS IN PARKINSON'S DISEASE
Parkinson’s disease (PD) is a debilitating movement disorder characterized by the loss of dopaminergic neurons in the substantia nigra. Little is known about the role of autoimmunity in PD pathogenesis. This thesis examines the role of two autoantigens, α-synuclein and the stress inducible …
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Verb Use in Parkinson's Disease
… are well documented in persons with Parkinson’s disease (PD). The grammatical and the motor theories have been proposed as possible explanations for verb impairments. The purpose of this study is to describe the use of low-motion and high-motion content verbs in PD in everyday …
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Rehabilitation Engineering in Parkinson's disease
… of postural control is a common consequence of Parkinson's disease (PD) that becomes more and more critical with the progression of the disease, in spite of the available medications. Postural instability is one of the most disabling features of PD and induces difficulties with postural …
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Modeling progression of Parkinson's disease
Chronic diseases progress slowly over years and impose a significant burden on patients. To help alleviate this burden, we propose tackling three clinical questions: predicting progression events, summarizing patient state, and identifying prognosis-driven subtypes. These questions are challenging …
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Subcortical Network Properties in Parkinson's Disease
Parkinson’s disease has been characterized as a “disconnection syndrome” reflecting the disruption of neural pathways. Network science analyses provide a promising way of further analyzing this characterization given the rich data they provide about the interrelationships between brain areas. In …
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Managing Uncertainty in Young-Onset Parkinson's Disease
Typically considered a disease of old-age, Parkinson’s disease can affect those younger in life, i.e., before the age of 55, when it is referred to as young-onset Parkinson’s disease (YOPD). Using constructionist grounded theory, this research sought to understand how, and why, individuals with …
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Social Aspects of Communication in Parkinson's Disease
Parkinson’s disease is a degenerative neurological condition which affects motor control, in almost all cases involving speech, and is frequently of many years duration. Much is known about speech production but less of the psychosocial consequences of the speech impairment (dysarthria). Accounts …
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Occulomotor Function and Locomotion in Parkinson's Disease
Many persons with Parkinson's disease: PD) experience difficulty turning that can lead to freezing of gait, falls, and an increased risk of fall-related injuries. We hypothesized, based on previous literature, that turning difficulty and freezing during turning may be related to deficits in the …
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Oculomotor Control in Patients with Parkinson's Disease
… investigating the eye movement behavior of Parkinson’s disease patients during fixation. This study objectively measured the eye movements of 36 patients with Parkinson’s disease, and 20 age matched controls. Stimuli consisted of ten standardized text passages first organized by Miller and …
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The role of copper in Parkinson's disease
… reported in the degenerating substantia nigra in Parkinson s disease, but the cause, and functional consequences, of this decrease are unknown. This thesis aimed to investigate neuronal copper levels and potential changes in copper transport in the Parkinson s disease brain to determine if altered …
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Intonation Processing In Individuals With Parkinson's Disease
<p>Parkinson's disease is a progressive neurodegenerative disease caused by the death of dopaminergic neurons in structures that make up the basal ganglia. Previous research has shown that damage to the basal ganglia can result in deficient (Cheang et al, 2004; Ma et al, 2007) production and …
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Towards a Better Treatment of Parkinson's disease
<p>Current therapies for Parkinson's Disease, the second most common neurodegenerative disorder, do not prevent disease progression, and induce extremely detrimental side-effects. Improving the best current pharmacological therapy, L-DOPA, carries important clinical benefits, partly by reducing the …
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Adherence therapy for people with Parkinson's disease
… Medication non-adherence is prevalent in Parkinson’s disease (PD). However, factors associated with non-adherence are unknown. Despite interventions to improve medication adherence being investigated in long-term conditions, few studies have focused on PD. Adherence Therapy (AT) is a …
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Characterization of Parkinson's Disease-associated LRRK2 Kinase
Parkinson’s disease (PD) is a progressive neurodegenerative disorder, which primarily results from the selective loss of dopaminergic neurons in the substantia nigra. Mutations in leucine-rich repeat kinase 2 (LRRK2) have been linked to autosomal familial and sporadic PD. It is now estimated that …
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Quantifying Parkinson's Disease Symptoms Using Mobile Devices
… assessments for evaluating the progression of Parkinson’s Disease are largely qualitative and based on small sets of data obtained from occasional doctor-patient interactions. There is a clinical need to improve the techniques used for mitigating common Parkinson’s Disease symptoms. Available …
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Molecular basis of MPTP-induced Parkinson's disease
… (MPTP) has resulted in irreversible symptoms of Parkinson's disease in several young drug abusers. It was found that this neurotoxicant selectively destroys neuronal cells in the substantia nigra of humans and other primates. Although the mechanism of action of MPTP is not fully understood, it is …
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Merging yoga and occupational therapy for Parkinson's disease
… risk self-management program for people with Parkinson's disease (Merging Yoga and Occupational Therapy for Parkinson's Disease [MY-OT for PD]), conduct a feasibility and pilot study, and analyze outcomes following the MY-OT for PD program. Method: This dissertation includes three studies. …
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Mechanisms of apathy in health and Parkinson's disease
… consequences of many neuropsychiatric diseases, including Parkinson's disease. Despite their prevalence and prognostic importance, their underlying mechanisms remain poorly understood. This knowledge gap presents a barrier to clinical assessment and treatment. Previous studies have …
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Human alkaloid biosynthesis : chemical inducers of Parkinson's disease?
… brain appears to be associated with the onset of Parkinson's disease (PD). Recently, a human protein bearing homology to an alkaloid synthase in plants was identified. This protein, termed BSCv, may catalyze alkaloid formation in humans. If such activity is confirmed, regulation of BSCv through …
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Behavioral impulsivity and hallucinations : insights from Parkinson's disease
Parkinson's disease (PD) is an age-related degenerative disease of the brain, characterized by motor, cognitive, and psychiatric symptoms. Neurologists and neuroscientists now understand that several symptoms of the disease, including hallucinations and impulse control behaviors, stem from the …
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