Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 34 for “"Parkinson's disease"”.
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Tower of California Performance Early in Parkinson's Disease
Cognitive impairment associated with Parkinson's disease (PD) is widely described in the literature. Executive dysfunction has been reported even when the patients are not experiencing dementia. A significant (24% - 50+%) number of PD patients display cognitive impairment from the onset of the …
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Frontal-lobe mediated word retrieval in Parkinson's disease
Parkinsonians have been shown to have difficulty with executive functioning, which is mediated by the frontal lobes of the brain. Tests of verbal fluency have been used to evaluate frontal lobe dysfunction. Letter fluency, however, may require different processes and mechanisms than semantic …
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Parkinson's disease: An investigation of relevant marital and family factors
… caregivers of persons suffering from idiopathic Parkinson's disease (PD) ; (b) explore factors believed to be associated with caregiver burden; and (c) investigate factors believed to be correlated with the amount of assistance in activities of daily living required by the patient. These factors …
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Investigating the mechanisms by which PINK1 protects against Parkinson's disease
… in a loss of PINK1 function, cause early onset Parkinson’s disease (PD). This thesis aimed to investigate the mechanisms by which PINK1 protects against PD, with a focus on PI3-kinase/Akt signalling. Akt signalling is central to cell survival, metabolism, protein and lipid homeostasis, and is …
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Tumor Necrosis Factor Dependent Mechanisms and Neuroprotective Strategies in Models of Parkinson's Disease
Parkinson's disease is a chronic, progressive, neurodegenerative disorder characterized by the loss of dopaminergic neurons in the substantia nigra that innervate the striatum. Although the nigral cell loss that causes motor dysfunction in Parkinson's disease has been identified for some time, the …
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The microbiome-gut-brain axis in preclinical alpha-synuclein models of Parkinson's disease
Parkinson’s disease (PD) is a progressive irreversible neurodegenerative disorder with no preventative treatment. PD is a multisystem disorder, affecting both central and peripheral nervous systems and is characterised by motor and non-motor symptoms. The primary pathological features of PD are the …
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Surprising Behavioral and Neurochemical Enhancements in Mice with Combined Mutations Linked to Parkinson's Disease
Parkinson’s disease (PD) is the second most common neurodegenerative disease, after Alzheimer’s disease, afflicting over a million people in the United States alone. PD is an age-dependent disease that causes progressive death of dopamine-producing neurons in the substrantia nigra and depleted …
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Characterisation of the molecular mechanisms of dopaminergic axonal growth and their impairment in Parkinson's disease
Parkinson’s disease (PD) is a neurodegenerative disease that affects 6.1 million people globally as of 2016. Axonal degeneration has been identified as the earliest event in the pathogenesis of the disease. For this reason, the application of neurotrophic growth factors for the protection and/or …
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The impact of drug-induced dyskinesias on rapid alternating movements in patients with Parkinson's disease
… druginduced dyskinesias (DID) in patients with Parkinson's disease (PD). The influence of dyskinesias on rapid alternating movements (RAM) was investigated in ten dyskinetic patients (DPD). Their motor performance was compared to that of ten age/gendermatched non-dyskinetic patients (NDPD) and …
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Changes in gait speed, gastrocnemius strength, and center of pressure for individuals living with Parkinson's disease
Background: Parkinson’s disease (PD) is a progressive disease that impacts the ability to walk in individuals with PD. Changes in gait abilities can lead to falls, changes in independence, and decreased quality of life. The purpose of this study was to create two regression analyses to investigate …
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Sex and LRRK2 Genotype Differences in Inflammation and Dopaminergic Neurodegeneration in a Multi-Hit Model of Parkinson's Disease
Parkinson’s disease (PD) is a multifactorial condition precipitated by environmental insults in conjunction with genetic vulnerabilities, sex differences, and aging. The objective of the current thesis was to explicate potential additive/synergistic effects of genetic LRRK2 anomalies and …
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Metabolism of Alpha-Synuclein by the 20S Proteasome
Parkinson's disease is one of several common neurodegenerative disorders that are related by the intracellular aggregation of the neuronal protein alpha-synuclein (alphaSyn) that normally associates with synaptic vesicles. Within the aggregates, a fraction of alphaSyn is truncated at the C-termini, …
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An Insight into Alpha-Synulcien's Biological Function and Its Pathogenesis in Neurodegenerative Disease
… alpha -synuclein that are genetically linked to Parkinson's disease, together with alpha -synuclein being the major component in Lewy bodies, has generated extensive interest in alpha -synuclein as a key component in neurodegenerative diseases. In recent years modeling this disease in transgenic …
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The Impact of Methylenetetrahydrofolate Reductase (MTHFR) Deficiency in a Paraquat Mouse Model of Parkinson’s Disease
The cause of Parkinson's disease (PD) remains unknown. Environmental toxicants such as paraquat have been linked to the characteristic dopaminergic (DA) neurodegeneration in the substantia nigra (SN); nutrition may also play a role. A common polymorphism (677C>T) in methylenetetrahydrofolate …
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Exploring SOD1 electron transfer, heterodimerization, and hetero-amyloid formation.
… of SOD1 have been linked to neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS) and, more recently, Parkinson's disease. To investigate the molecular factors underlying these processes, this dissertation examines the protein from the inside out, focusing on three concepts: …
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Development of P7C3-Class of Neuroprotective Molecules
Neurodegenerative diseases and disorders are physically, emotionally and financially devastating for patients and their families, and are also associated with great costs to caregivers and society. All of these neuropsychiatric conditions have in common neuronal cell death, for which there is …
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Adaptive Detection of Beta Bursts of Local Field Potentials Recorded from Subthalamic Nucleus in Patients with Parkinson’s Disease
Parkinson's Disease (PD) affects 1% of the world population, with this number expected to increase within the following years. Local field potentials (LFPs) recorded from deep brain stimulation (DBS) leads placed into the motor territory of the subthalamic nucleus (STN) can be used to investigate …
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A Data-Driven Approach for Deriving Parkinson’s Disease Subtypes and Related Trajectories of Cognitive and Motor Function
Parkinson's disease (PD) is a progressive neurological illness that involves a variety of motor and non-motor features, with remarkable heterogeneity in clinical presentation and symptom progression. Previous studies have attempted to identify PD subtypes to better understand the clinical …
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Understanding the Atomic-Scale Mechanisms of the Human [alpha]4[beta]2 Nicotinic Acetylcholine Receptor
… dysfunction has been linked to neurodegenerative diseases and mental illnesses including schizophrenia, Alzheimer's disease, epilepsy, Parkinson's disease and nicotine addiction. Because of its key role in the brain and connection to diseases, I sought to understand the basic principles underlying …
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