Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 72 for “"Parkin"”.
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The mechanism of Parkin activation by PINK1 phosphorylation
Mutations in the E3 Ub ligase Parkin (PARK2) and the protein kinase PINK1 (PARK6) are genetically linked to Young-Onset Parkinson’s Disease. The two enzymes orchestrate clearance of damaged, cytotoxic mitochondria through a specialized form of autophagy termed mitophagy. By phosphorylating …
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Regulation of the Parkin E3 ligase by PINK1-dependent phosphorylation
Parkinson’s disease (PD) is the second most common neurodegenerative disorder affecting around 1% of the population over the age of 65 worldwide. While the majority of cases are sporadic, groundbreaking genetic research over the last two decades has revealed a complicated network of genes …
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Analysis of PINK1/Parkin-related mitochondrial quality control in Drosophila
… disorders. Interestingly, two proteins linked to Parkinson’s Disease (PD), Parkin, a cytosolic ubiquitin ligase, and PINK1, a mitochondrially targeted kinase, have been shown to play key roles in this mitophagy. However, little is known about their impact on basal mitophagy in vivo. Moreover, …
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Advancing understanding of endogenous PINK1-Parkin signalling linked to Parkinson’s disease
Parkinson’s disease (PD) is the second most common neurodegenerative disorder. Discoveries of heritable, disease associated mutations in multiple genes has linked mitochondrial dysfunction with PD. Two of these gene products, PINK1 and Parkin, function together in a common pathway. The PINK1 kinase …
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PARKIN, BLM AND EXO1: INVOLVEMENT IN POST-NER ACTIVITY IN NON-REPLICATING CELLS
… an impairment of the survival of these cells. Parkin, an E3 ubiquitin ligase mutated in autosomal recessive juvenile parkinsonism, has been reported to play a role in PCNA ubiquitylation; we investigated its potential role in the response to bulky lesions in non-replicating, neuron-like cells. …
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The Role of Parkin-Mediated Mitophagy During Aging and Exercise in Skeletal Muscle
… degradation through a process termed mitophagy. Parkin is a ubiquitin ligase that is involved in mitophagy and the turnover of mitochondria. Parkin is extensively studied in neuronal tissue, but its role in skeletal muscle has not been fully explored. The overall purpose of this dissertation was …
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Molecular and Genetic Analysis of Parkin in Microglia Activation and Inflammation-Related Neurodegeneration
Parkinson’s disease (PD) is a progressive, neurodegenerative disease characterized by the loss of dopaminergic (DA) neurons in the substantia nigra (SN). Genetic mutations account for only 5-10% of PD cases. Oxidative stress and inflammation have both been linked to sporadic PD. …
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Mutations in PARKIN (pdr-1) Results in Increased Reproductive Fitness in C. elegans
<p>Parkinson’s disease (PD) is largely an idiopathic disease that includes contributions from both genetic and environmental factors, with aging itself being the largest risk factor. These combined susceptibility factors are believed to accumulatively contribute to initiation and progression of …
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A Study of alpha-Synuclein, Parkin and TDP-43 ; Proteins Implicated in Neurodegenerative Disease.
… is a 14.5 kDa neuronal protein associated with Parkinson's disease (PD) and related disorders. Aggregated protein inclusions called Lewy bodies found in the brain in PD contain alphaS. Rare inherited forms of early-onset PD are caused by autosomal dominant mutations in alphaS or by autosomal …
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Exploring Parkinson’s disease associated LRRK2 and PINK1/Parkin signal transduction pathways within immune cells
<b>Introduction</b>: Parkinson’s disease (PD) is the second most common neurodegenerative disorder in the world1. Whilst the majority of PD patients have no known cause of the disease (‘sporadic’), around 5-10% of PD patients have genetic, familial forms of the disease2. LRRK2 and PINK1 are two …
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Determination of the Composition and Architecture of the Mitochondrial Ubiquitome in PINK1/Parkin Mitophagy
Parkinson’s Disease is the second most common age-related neurodegenerative disorder, with multiple lines of evidence suggesting that mitochondrial dysfunction may underlie the etiology of the disease. The kinase PINK1, and the ubiquitin (Ub) E3 ligase Parkin, function in a pathway to maintain …
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Behavioral, Neurochemical, and Histological Characterization of Mice Deficient for Parkin, DJ-1, and Antioxidant Proteins
Parkinson’s disease is a progressive neurodegenerative disease characterized by a loss of dopaminergic neurons in the substantia nigra. The cause of Parkinson’s disease remains uncertain, however, evidence implicates mitochondrial dysfunction and oxidative stress with selective vulnerability of …
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Identifizierung und Charakterisierung einer Protein-Protein-Interaktion beim Morbus Parkinson
… der proteasomalen Untereinheit alpha4 mit Parkin untersucht. Frühere Untersuchungen in einem Yeast-Two-Hybrid-Screen mit einer humanen fötalen cDNA-Hirn-Bibliothek hatten Hinweise auf eine solche Wechselwirkung ergeben. Um die Bindung zwischen Parkin und der alpha4-Untereinheit zu …
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Axonal transport and life cycle of mitochondria in Parkinson's disease model
… preserving compartmentalized cellular function. Parkin, an E3 ubiquitin ligase associated with familial Parkinson’s disease, has been implicated in mitochondrial dynamics and removal. However, it is not clear how Parkin plays a role in mitochondrial turnover in vivo, and whether the mature …
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Role And Impact Of The Gut Microbiota In A Drosophila Model For Parkinsonism
… axis in Drosophila models of autosomal recessive parkinsonism and observed a five-fold increase in the gut microbial load of aged parkin animals. The microbial load of pink1 animals was unchanged, suggesting a Pink1-independent role for parkin in maintaining microbial load numbers within normal …
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Surprising Behavioral and Neurochemical Enhancements in Mice with Combined Mutations Linked to Parkinson's Disease
Parkinson’s disease (PD) is the second most common neurodegenerative disease, after Alzheimer’s disease, afflicting over a million people in the United States alone. PD is an age-dependent disease that causes progressive death of dopamine-producing neurons in the substrantia nigra and depleted …
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Simulation studies of the structure-function relationship of two biological processes: proton pumping in cbb3 oxidase and activation of Parkin
… c oxidase (cbb3) and an E3 ubiquitin ligase (Parkin).<br/><br/>Cbb3 is a C-type terminal oxidase responsible for catalyzing the final step of aerobic respiration (namely the reduction of oxygen to water) and coupling this redox reaction to the active translocation of protons across the …
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Biochemical characterisation of the Parkinson's disease-associated kinase PINK1: Insights from the insect world
Parkinson’s disease (PD) is the second most common neurodegenerative disorder, affecting approximately 1% of the population over the age of 65. Around 5% of these cases can be linked to mutations in known genes, one of which is the PINK1 gene, first linked to PD a decade ago. Since then, over 30 …
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Independent Functions Of Clueless In Differential Integrin Secretion And Mitochondrial Quality Control In Drosophila Muscle
… separable from its mitochondrial function. PINK1/Parkin-mediated MQC requires valosin-containing protein (VCP)-dependent Mitofusin/Marf proteasomal degradation to prevent damaged mitochondria from fusing with healthy ones, facilitating their clearance by autophagy (mitophagy). clu was found to …
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Be Eaten to Stay Healthy: Elucidating the Mechanisms of Mitochondrial Quality Control by Mitophagy
… as an important quality control mechanism. The Parkinson's disease related proteins phosphatase and tensin homolog-induced putative kinase 1 (PINK1) and Parkin have been identified as important regulators of mitophagy in mammalian cells, directly linking mitophagy to neurodegeneration. The role …
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