Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 54 for “"Parasitic Diseases"”.
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Characterising the bacterial microbiota of Phlebotomus and Glossina insects : vectors of parasitic diseases
… and leishmaniasis are neglected tropical diseases caused by kinetoplast parasites and transmitted between human hosts by biting flies. In this thesis the bacterial microbiota of tsetse flies and sand flies, the vectors of trypanosomiasis and leishmaniasis respectively, were examined using …
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Developing New Chemotherapeutic Agents Against Bone Resorption and Parasitic Diseases Through Computer -Aided Drug Design
Using the above mentioned 3D-QSAR methods we have developed predictive models of the inhibition of human farnesyl pyrophosphate synthase (FPPS), important for osteoclast function and survival as well as Trypanosoma brucei FPPS, soluble vacuolar pyrophosphatase and phosphoglycerate kinase, all …
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Integration of In Silico and In Vitro ADMET properties in lead identification and optimization of compounds for the treatment of parasitic diseases
Parasitic infections are the major causes of illness and death in tropical regions especially in Africa. The main parasitic diseases include leishmaniasis, filariasis, malaria, river blindness, Chagas disease and schistosomiasis. With the absence of vaccines, treatment relies mainly on chemotherapy …
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Design of Thermosensitive Hydrogel for Extended-Release of Praziquantel
Parasitic diseases are a severe threat to people and animals. Praziquantel is the most comanti-parasitic drug with high efficiency, and it has been used to treat parasitic diseases for many years. However, it has very strong gastrointestinal and liver metabolism that leads to a strong first-pass …
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Elucidating Targets for Infectious Diseases and Cancer: A Computational Approach
Cancer and infectious diseases represent huge health threats to societies around the globe. Bisphosphonate drugs, long known for their ability to treat bone resorption diseases, have also served as the template for designing new agents against a variety of other diseases. In this work, …
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An Improved Understanding of Bisphosphonates Through Computational Techniques
… useful in the treatment of human bone resorption diseases, parasitic diseases, and in the immunotherapeutic treatment of some diseases, such as cancer.
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Antiprotozoal quinolines containing electrophilic moieties
… the cysteine proteases in malaria and other parasitic diseases as potential targets for new chemotherapy due to their critical roles in the life cycles of the causative agents. Due to their role in the antimalarial activity of clinically available drugs, quinolines were used as scaffolds to …
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Engineering non-immunoglobulin binding proteins for in vitro diagnostic Tests
… million deaths were attributed to infectious and parasitic diseases. Although many of these diseases are preventable and treatable, resource-constrained regions often lack access to rapid and accurate diagnostic tests to appropriately diagnose and treat these diseases. In order to improve the …
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New Chemotherapeutic Approaches for the Treatment of Parasitic Protozoan Diseases
… chemotherapeutic approaches for the treatment of parasitic protozoan diseases. The work presented in this thesis focuses on the design, synthesis, and screening (in vitro and in vivo) of bisphosphonates as a novel class of anti-parasitic agents. The infectious agents targeted in this study are …
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Studies of anti-trypanosomal active triterpenoids from some African propolis
… is a drastic need for new and improved drugs for parasitic diseases such as African Trypanosomiasis which is a major global health problem with high endemicity in developing countries due to the alarming rate of resurgence of the disease, drug related adverse effects and drawbacks of the existing …
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Synthesis and biological evaluation of antiparasitic Cysteine protease inhibitors based on the Isatin Scaffold
… available drugs against malaria and other parasitic diseases. This necessitates the development of new drugs. Meanwhile, the cysteine protease family of enzymes has been identified as potential targets for new modes of chemotherapy due to the numerous critical roles they play in the …
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Estudo acerca da ocorrência de enteroparasitos em hortaliças consumidas pela comunidade universitária - João Pessoa/PB
The intesti nal parasites are diseases that affect the world and damages represent a serious public health problem. In view of the increased consumption of vegetables by the entire population and considering the fact of consumption "in nature" if the analysis is neces sary, since the transmission …
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Small molecules with anti-trypanosomal and anti-leishmanial activity
Parasitic diseases such as Human African Trypanosomiasis (HAT), Chagas disease and Leishmaniasis cause thousands of fatalities each year. Current chemotherapy is based on drugs discovered over 60 years ago that are expensive and difficult to administer. The drug-pipeline is virtually dry and the …
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Pesquisa de parasitas intestinais em crianças e manipuladores de alimentos da creche Lyndemberg Vieira, João Pessoa - Paraíba.
… conditions contribute to the high prevalence of parasitic diseases in Brazil. Thus, the aim of this study was to investigate intestinal parasites in children and food handlers, determine the frequency of intestinal parasites, as well as knowing the conditions of personal hygiene and health …
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Accelerating antimalarial drug discovery through repositioning
Of the plethora of parasitic diseases that afflict mankind, malaria remains the most significant with 100-300 million cases reported annually and 600,000 fatalities. Treatment and control measures have been hampered by the emergence of drug resistance to most antimalarial therapies. Early signs of …
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Perfil enteroparasitológico dos pacientes atendidos no ambulatório do Hospital Universitário Lauro Wanderley de acordo com as condições climáticas.
… education in or der to promote the prevention of parasitic diseases and the wettest periods was an increase of cases of infection with intestinal parasite s compared to periods of low rainfal
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A review of environmental determinants of schistosomiasis prevalence in Africa
… on schistosomiasis, one of the most devastating parasitic diseases in tropical countries. However, environmental determinants have not fully been explored as important means of additional strategies for prevention and control of the disease. Therefore, the aim of this study was to review …
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A review of environmental determinants of schistosomiasis prevalence in Africa
… on schistosomiasis, one of the most devastating parasitic diseases in tropical countries. However, environmental determinants have not fully been explored as important means of additional strategies for prevention and control of the disease. Therefore, the aim of this study was to review …
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Nuclear Receptor Controls Nematode Metabolism And Development: Insight Into Man’s Nemesis, the Conqueror Worm
… conserved in other nematode species, especially parasitic ones, is also unknown. One aspect of my studies is to investigate the molecular mechanisms by which this DA-DAF-12 signaling pathway regulates the C. elegans development. By measuring a series of metabolic parameters, we demonstrated that …
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Molecular Diagnosis and Anthelmintic Control of Trichostrongyle and Toxicara nematodes in Bison bison Herds from the U.S.A. Central Great Plains
… many challenges, including the transmission of parasitic diseases such as trichostrongylosis and toxocariasis into and within their herds. These diseases can reduce animal production and cause occasional death. There have been no surveys to identify gastrointestinal nematodes common to bison …
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