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Showing 1 to 15 of 15 for “"Paraoxonase"”.
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CLINICAL APPLICATIONS OF PARAOXONASE-1 IN DOMESTIC ANIMALS: BEYOND CONVENTIONAL INFLAMMATORY MARKERS
… research, interest has grown about the role of Paraoxonase-1 (PON-1) in the pathogenesis and diagnosis of many diseases characterized by inflammation and/or oxidative stress, both in human and veterinary medicine. In veterinary species, PON-1 measurement is to date primarily restricted to the …
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Development of metabolic pathways for the biosynthesis of hydroxyacids and lactones
… from levulinate by adding the lactonase paraoxonase I (PON1) to the P. putida hydroxyvalerate production system. Because 4VL was found to exist in a pH-dependent equilibrium with 4HV, the lactonase was expressed extracytosolically in acidic media to achieve significant titers of 4VL. The …
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A maternal high fat diet represses the expression of antioxidant defense genes and induces the cellular senescence pathway in the liver of male offspring rats
… (Gpx1), Cu/Zn superoxide dismutase (Sod1), paraoxonase enzymes (Pon1, Pon2, and Pon3) were significantly lower in the liver of HF/C pups than in C/C pups. The expression of p16INK4a, a marker of cellular senescence, and cyclooxygenase-2 (Cox2), a pro-inflammatory marker, was significantly …
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Genetic polymorphisms and organophosphate neurotoxicity amongst emerging farmers in the Western Cape
… (GST), N-acetyltransferases (NAT) and Paraoxonase (PON1). RESULTS: Median age was 39 (30-48) and most had 9 years of education or less (65.5%). 54% of the participants were OP pesticide applicators. There was a low prevalence of the GST null genotype (GSTT-1% and GSTM-16%) and the GA …
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Discovery, characterization, and rational design of the enzymes involved in monoterpene indole alkaloid biosynthesis in Madagascar periwinkle
… synthase and the related hydrolase, paraoxonase, rational mutagenesis was used to convert strictosidine synthase into a hydrolase. Intriguingly, during the rational design process, the function of a closely related strictosidine synthase homolog was also functionally characterized as …
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Investigating high-density lipoprotein (HDL) subfractions, composition and functionality in people living with HIV
… efflux capacity, anti-oxidative activity (paraoxonase-1 (PON-1) activity) and anti-thrombotic activity (platelet-activating factor acetylhydrolase (PAF-AH) activity). HDL subfractions were measured using the Lipoprint® system. Results: HIV ART-naïve patients had lower HDL cholesterol than …
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Effects of pomegranate extract supplementation on cardiovascular disease risk and physical function in patients with chronic renal failure
… after controlling for baseline BP levels. Paraoxonase-1 activity, a measure of antioxidant capacity, increased by 26.6% (p<0.05) in POM, compared to no significant change in CON. However, pomegranate supplementation had no effect on other markers of CVD risk (e.g., β stiffness index, …
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IDENTIFICAZIONE DI NUOVI BIOMARKER E METODI ANALITICI INNOVATIVI IN PATOLOGIA CLINICA VETERINARIA
… study about FIP infection in cats. The paraoxonase 1 activity in dogs is the last inflammatory maker investigated, and results show a probable biological behaviour as a negative acute phase protein. 3. Hypertension markers: homocysteine and entothelin-1 (ET-1). Hypertension usually is …
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Understanding the relationship between high-density lipoprotein (HDL) subclass distribution and functionality in patients at risk of cardiovascular disease
… apolipoproteins A1 and M (ApoA1 and ApoM), paraoxonase (PON1) and platelet activating factor acetylhydrolase (PAF-AH) expression (using Western blotting) and sphingosine-1-phosphate (S1P) content (using mass spectometry). Levels of large, intermediate and small HDL subclasses were measured …
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Effects of Peripartal Supplementation of Yeast-Based Products on Performance, Rumen Fermentation Profile, and Circadian Rhythms in Dairy Cows
… and a lower concentration of paraoxonase than CTL cows. Regarding daily rhythms, we observed a lower mesor (i.e., rhythm-adjusted mean) in prepartal isovalerate, valerate, isobutyrate, and NEFA in PB cows compared with CTL. Lower postpartal mesor for ruminal pH, lactate, …
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Über die Phosphoryloxim-Hydrolase des Plasmas, ein Enzym, das die Effizienz der Oximtherapie bei Organophosphat-Vergiftungen erheblich steigert
… nach der Identität der POX-Hydrolase und der Paraoxonase (hPON1) als polymorph exprimiertes Enzym. Die beiden Enzym-aktivitäten verhielten sich während der Aufreinigung und gegenübe r verschiedenen Protein-modifizierenden Reagenzien ähnlich, so daß vermutlich am Aufbau der aktiven Zentren …
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Exploring the relationship between shifts in high-density lipoprotein (HDL) particle subclass distribution/functionality and cardiac function in doxorubicin (DOX)-induced cardiotoxicity
… functionality was assessed by measuring paraoxonase-1 (PON1) activity. The ability of isolated HDL particles to protect against DOX-induced cytotoxicity was assessed in H9C2 cells and measured using the adenosine-triphosphate (ATP) assay. Results: DOX-induced subclinical cardiotoxicity …
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Effect of rumen-protected methionine on placenta metabolism, animal performance, and immune-metabolism of dairy cows during the periparturient and early lactation periods
… γ-glutamyl transferase, cholesterol and paraoxonase indicating better liver function. Among the inflammation biomarkers measured, MET led to greater albumin (negative acute-phase protein) and lower haptoglobin than control cows. Cows supplemented with MET had greater plasma concentration …
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Enzyme and Directed Evolution Technologies For Nerve Agent Neutralisation
… (PTE) and PON1, a mammalian member of the Serum paraoxonase (PONs) family. These enzymes have excellent catalytic properties towards some OPs, but relatively poor activities against others. It has been possible to alter PTE substrate specificity by rational site-mutagenesis, but with little …
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A MULTIMODAL CLINICAL AND DIAGNOSTIC APPROACH TO BOVINE RESPIRATORY DISEASE COMPLEX (BRDC) IN DAIRY CALVES
… blood gas examination and serum titration of paraoxonase-1 (PON-1) as a biomarker of inflammation. Calves were grouped as "healthy" or "calves with BP" based on clinical scores (Wisconsin [WISC5], California [CALIF], an alternative Wisconsin approach [WISC2points]) and two TUS cut-offs (≥ 1 …