Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 20 for “"Paramyxovirus"”.
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DEVELOPMENT OF AVIAN PARAMYXOVIRUS VECTORED VACCINES
Avian Avulaviruses (formerly Avian Paramyxoviruses, APMV) are important pathogens of avian species and have been used as viral vectors for more than two decades. Among all APMVs, Newcastle disease virus (NDV or APMV-1) has been most extensively used as a vaccine vector for protection against avian …
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Evaluation of the potential functions of Avian paramyxovirus Accessory proteins
Avian paramyxoviruses (APMVs) consist of twelve distinct serotypes (APMV-1 to -12) isolated from a wide variety of domestic and wild birds. APMV-1/Newcastle disease virus (NDV) is the most characterized and globally important avian pathogen, because of the huge economic loss associated with the …
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Viral and Cell Type Specific Host Factors that Contribute to Paramyxovirus Antiviral Responses
… tropism, dissemination, and pathogenesis. The paramyxovirus simian virus 5 (SV5) is able to establish highly productive, persistent infections of cultured epithelial cells with minimal induction of host cell responses. In contrast, two SV5 mutants induce production of proinflammatory cytokines, …
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Determination of the seroprevalence of Newcastle disease virus (Avian paramyxovirus type 1) in Zambian backyard chicken flocks
The specific objectives of this study were to determine the Newcastle disease virus (NDV) antibody titres from the chicken sera collected from various districts and provinces of Zambia and to determine the seroprevalence of ND in Zambian backyard chickens. Results showed that 73.9 % of the birds …
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Respiratory infection with the paramyxovirus SV5 results in maturation and cytokine secretion in CD103- and CD103+ dendritic cell subsets.
… intranasal infection of BALB/c mice with paramyxovirus recombinant Simian Virus 5(rSV5-eGFP-p60) as a model to explore the behavior of these four DC subsets in vivo with regard to regulation of costimulatory molecules and cytokine secretion. We found that the number of mature DC, defined …
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Charakterisierung von reptilienpathogenen Paramyxoviren und Analyse des prokaryotisch exprimierten partiellen Fusionsgens
… were investigated. Identifying the isolates as paramyxoviruses showing characteristic cytopathic effect, was carried out by electronmicroscopy and RNA-PCR of two partial genes (L and F). After sequencing RNA-PCR amplicons, identical sequences were found for the reptilian paramyxoviruses (RPMV) …
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Exploring Nipah virus strain differences through use of recombinant and chimeric viruses as well as utilization of a novel 3D human lung model
Nipah virus (NiV) is a highly pathogenic paramyxovirus that causes lethal encephalitis and respiratory illness in humans. There are two variants of NiV - NiV Malaysia (NiVM) and NiV Bangladesh (NiVB). Despite high sequence homology between the strains, there are several key differences in …
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Virus-Based Nanoparticles for Tumor Selective Targeting and Oncolysis
… Newcastle disease virus (NDV), an avian paramyxovirus, is naturally tumor-selective and inherently oncolytic. Our approach is to develop NDV-based nanoparticles (VBNP) for oncolytic virotherapy. VBNPs are non-infectious and non-replicating and are relatively safe. We obtained VBNPs by …
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Inducible Epithelial Resistance Against Acute Viral Pneumonia and Chronic Asthma
… elucidated. Here, we show in a lethal paramyxovirus model that Pam2-ODN-enhanced survival is associated with robust virus inactivation by reactive oxygen species (ROS), which occurs prior to internalization by lung epithelial cells. We also found that mortality in sham-treated mice …
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Inducible Epithelial Resistance Against Acute Viral Pneumonia and Chronic Asthma
… elucidated. Here, we show in a lethal paramyxovirus model that Pam2-ODN-enhanced survival is associated with robust virus inactivation by reactive oxygen species (ROS), which occurs prior to internalization by lung epithelial cells. We also found that mortality in sham-treated mice …
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Challenge studies in chickens to evaluate the efficacy of commercial Newcastle disease vaccines against the strains of Newcastle disease virus prevalent in South Africa since 2002
… strain belonging to lineage 5d/VIId (“goose paramyxovirus” - GPMV). Control of the disease has proved difficult with commercially available vaccines appearing ineffective. In the first of two studies, broilers chicks were vaccinated with VG-GA vaccine (lineage II), then challenged with both …
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A strategy to suppress STAT1 signalling conserved in pathogenic poxviruses and paramyxoviruses
… V protein from Nipah virus, a member of the paramyxovirus family showed sequence similarity to the STAT1-binding region of 018. We showed, like 018, Nipah V protein blocks STAT1 association with the active IFN receptor. Furthermore, we provide mechanistic detail of the Nipah V:STAT1 …
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Characterization of Atypical Hemolytic Ornithobacterium rhinotracheale Isolates and Comparison with the Normal Non-Hemolytic Phenotype
… virus (vaccine induced), Bordetella avium, and paramyxovirus-1 was 100%, 74.8%, and 6.3% respectively. No significant interactions were detected. The type strain of ORT is characteristically non-hemolytic at least for 96 hours at 37°C on Columbia Blood Agar. In recent years, atypical isolates …
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Elucidating Mechanisms of Immunity to Nipah Virus Infection through Generation of Attenuated Viruses and a Single-Cycle Vectored Vaccine
Nipah virus (NiV) is an emerging paramyxovirus that has caused outbreaks with high case-fatality rates in South and Southeast Asia. Mechanisms of NiV virulence are poorly understood, and there is no licensed vaccine nor treatment. Accessory proteins produced from the NiV P gene through …
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Targeted Oncolytic Virotherapy Using Newcastle Disease Virus Against Prostate Cancer
… Newcastle Disease Virus (NDV), an avian paramyxovirus, is a safe and promising OV successfully used in many clinical trials. NDV is inherently tumor selective and cytotoxic but replication restricted in normal cells. But, systemically delivered NDV fails to reach solid tumors in …
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The spread of Nipah and chikungunya viruses: implications for control
… remain poorly quantified. Nipah virus is a Paramyxovirus that circulates in Pteropus bats across South and Southeast Asia. Most outbreaks in humans are rare and localized, but infection is often lethal and human-to-human transmission has been observed. Chikungunya virus is an Alphavirus …
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Complete Genome Sequence and Pathogenicity of Two Swine Parainfluenzaviruses Isolated from Pigs in the United States
… A large and diverse host species are infected by paramyxoviruses, including avian, porcine, canine, bovine, equine, ovine, reptiles, aquatic species and humans. In the last few decades, many novel paramyxoviruses have emerged causing catastrophic illnesses in different aquatic and terrestrial …
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Regulation of the Human Parainfluenza Virus (hPIV3) Fusion Protein
<p>Paramyxoviruses include a number of important human pathogens, including measles virus, mumps virus, and the human parainfluenza viruses (hPIV) 1-4, as well as several animal pathogens, such as Sendai virus, Nipah virus and Hendra virus. The creation of effective drugs and vaccines against this …