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Showing 1 to 7 of 7 for “"Parallel plate flow chamber"”.
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Biomedical research application of a novel double-layer parallel-plate flow chamber
… Complicated designs of the conventional flow devices, however, have impeded such implementation. In the present study, we designed and developed a novel parallel-plate flow chamber (PPFC). It consists of multiple layers of different materials to adjust the required geometries of the …
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Examination of a system for the mechanistic study of tumor cell-platelet interactions under well-defined flow conditions
The compelling evidence that platelets play a contributory role in hematogenous metastasis raises a need to elucidate the molecular mechanisms by which tumor cells activate and adhere to platelets. To model the in vivo interactions of platelets with arrested tumor cells, heparinized …
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Stimulation of angiogenesis through collagen gel by applying shear stress and interstitial flow
… understanding of this mechanical stimulus, a parallel plate flow chamber was designed and tested to elicit a constant laminar flow onto a monolayer of endothelial cells. The goal of this research was to develop a more physiologically similar in vitro system to study the effects of shear stress …
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The Response of Preosteoblasts to Combined Shear and Thermal Stress for Bone Tissue Engineering
… (control), shear stress at 1 dyne/cm2 using a parallel plate flow chamber, thermal stress in a 42°C incubator, or combined shear and thermal stress (1 dyne/cm2 at 42°C). Stress treatments were applied on Day 2, Day 6, and Day 10. To assess the early response of cells to stress treatments, we …
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Antithrombotic agents under flow conditions
… proteins and blood cells under a wide range of flow rates. To mimic these conditions in vitro, a parallel plate flow chamber with human umbilical vein endothelial cells (HUVEC) or extracellular matrix (ECM) has been developed. A method to investigate thrombin generation (TG) in platelet rich …
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Functional Significance of the Upregulation of Adhesion Molecules on Irradiated Endothelial Cells
… We have also developed an in vitro flow model to study the functional consequences of the radiation induced upregulation of adhesion molecules, primarily E-selectin and ICAM-1. Endothelial cells were grown in 35mm dishes and irradiated with a single dose of 10 Gy. HL60 (human …
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The role of death-associated protein kinase in endothelial apoptosis under fluid shear stress
… are the interface between hemodynamic fluid flow and vascular tissue contact. They actively translate physical and chemical stimuli into intracellular signaling cascades which in turn regulate cell function, and endothelial dysfunction leads to inflammation and diseased conditions. For …