Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"Paracrine Signalling"”.
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The Epicardium as the Conductor of Cardiovascular Cells in Cardiac Regeneration
… the observed benefits of co-transplantation is paracrine-mediated effects of the epicardium towards CMs and endothelial cells (EC). While RNA sequencing data has been used to identify putative players in hESC-EPIs, little is known about their involvement in mediating hESC-CM maturation and …
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Identification of mesenchymal genes involved in prostate organogenesis by LongSAGE analysis
… a prostate. Testosterone acts in concert with paracrine signalling from inductive mesenchyme to regulate epithelial growth and branching of the prostate. The ventral mesenchymal pad (VMP) is an area of inductive mesenchyme that is rich in regulatory growth factors of which few have been …
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Oncogene-induced reprogramming of heterotypic cellular interactions
KRAS is a critical signalling hub that orchestrates fundamental cellular decisions such as cell survival, proliferation and differentiation. Activating mutations in KRAS are among the most frequently occurring oncogenic mutations driving cancers that are particularly refractory to therapy (e.g., …
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Investigation of efficacy and mechanisms of action in mesenchymal stromal cell therapy for chronic lung diseases
… that have become the focus of research due to paracrine mediated tissue reparative and protective effects. This study has examined the use of MSC for the treatment of inflammatory and fibrotic lung diseases, specifically Chronic Obstructive Pulmonary Disease (COPD) and Idiopathic Pulmonary …
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The exploitation of neuronal survival factors in Burkitt’s lymphoma and germinal centre B cells
… was to question FDCs as potential providers of paracrine neurotrophin signalling to Burkitt’s lymphoma B cells. Neurotrophin and neurotrophin receptor expression was detected by flow cytometry, confocal microscopy, reverse transcription polymerase chain reaction (PCR) and real time PCR methods. …
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Autonomous and non-autonomous regulation of chromatin structure during cellular senescence
… outcomes. In addition to autocrine and paracrine signalling mediated by factors of the senescence-associated secretory phenotype (SASP), we have recently identified that NOTCH1 can drive a unique form of senescence in adjacent cells via juxtacrine signalling. Here, we show that NOTCH1 …
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Targeting macrophages GLP-1 receptor pathways as emerging therapies to ameliorate cardiac remodelling associated with diabetes
… effects through modulation of inflammatory signalling. Therefore, the aim of this thesis was to study the effects of the GLP-1 analogue, liraglutide, in diabetes with a specific focus on cardiac inflammation. <br/><br/>Based on our previous findings, we initially designed modified GLP-1 …
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Unravelling the epigenetic landscape of pancreatic cancer: The role of cancer-associated fibroblasts in transcription factor regulation
… IFN-β was sufficient to attenuate iCAF-derived paracrine signalling and suppress STAT1 phosphorylation. In contrast, myCAFs promoted SOX2 upregulation in cancer cells through direct cell-cell contact. SOX2 was recruited to enhancer elements and mediated expression of genes associated with …
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Towards elucidating the function of the oocyte Subcortical Maternal Complex: A multi-omic analysis of an Nlrp5-null murine model
… regulators of ovarian follicle development via paracrine signalling, were also notably reduced in *Nlrp5*-null oocytes. Other proteins altered in *Nlrp5*-null oocytes include epigenetic modifiers DNMT3L and UHRF1, both of which are reduced in the mutant, the former by over 75%, and the latter by …
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Effects of HOXB4 downstream targets on the haemopoietic differentiation of pluripotent stem cells
… haemopoietic differentiation of mouse ESCs in a paracrine manner. Microarray analysis identified a number of secreted factors upregulated by HOXB4 potentially mediating this paracrine effect. The aim of this study was to assess whether these factors alone and/or in combination can enhance the in …
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Microfluidic platforms for studying cell behavior in complex microenvironments
For better translation from basic science to everyday clinical practice, biomedical research must attempt to understand cellular behavior that occurs in vivo. This is assuredly a daunting task as cells receive many cues from the surrounding microenvironment. Cues such as changes in the …
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Elucidating the role of Gremlin1 in colorectal cancer
… survival. Furthermore, we identified a novel paracrine signalling circuit, involving the secretion of GREM1 from cancer associated fibroblasts and uptake by surrounding colonic epithelial cells. We extended these findings to show that non-GREM1 expressing cells were capable of taking up GREM1 …
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The role of the Igf2/H19 locus in regulating murine placental endocrine capacity
… and produces an abundance of hormones and signalling factors that adapt maternal metabolism to support fetal growth. In mice, these functions are performed in two distinct placental regions, the transport labyrinth zone (Lz) and the endocrine junctional zone (Jz). Insulin like growth factor …