Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"Paracrine Effects"”.
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The Derivation of the Myocardial, Epicardial and Endocardial Lineages from Human Pluripotent Stem Cells
… formation of valves. The endocardium also exerts paracrine effects on the adjacent myocardium, promoting the proliferation and maturation of cardiomyocytes during the formation of ventricular trabeculae. While protocols for the efficient generation of cardiomyocytes from human embryonic and …
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Developing Novel Therapies Targeting the Tumor Microenvironment of Aggressive Breast Cancer
… secretion in cancer cells, which generates the paracrine effects with AXL-regulated CCR5 in M2 macrophages and consequently suppresses the recruitment of cytotoxic T cell population.</p> <p>In conclusion, targeting AXL alone or in combination with TBK1 represents potentially effective therapies …
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IGF2 Promotes Activation of Estrogen Receptors in Basal-like Breast Cancer Cells
The autocrine-paracrine effects of IGF2 are important in the growth and differentiation of normal breast. In breast cancer (BC), IGF2 is initially stimulated by estrogen, progesterone and prolactin to regulate proliferation and cancer progression. These actions are mediated by the IGF-1R and …
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Biomechanical regulation of arteriogenesis : defining critical endothelial-dependent events
… coronary collateral vessels and the subsequent paracrine effects on smooth muscle cells. Initially, a lumped parameter model of the human coronary collateral circulation was used to simulate normal (NCC) and adaptive remodeling (ACC) coronary collateral shear stress waveforms. These waveforms …
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Regulation of PPARgamma Activity by mTOR in Adipogenesis
… troglitazone was found to reverse the inhibitory effects of both rapamycin and amino acid deprivation, implicating therapeutic value of these drugs to counter side effects of rapamycin as an immunosuppressant. A potential role of mTOR in IL-6 stimulated STAT3 pathway was also investigated and …
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KUPFFER CELLS¿ MITOCHONDRIAL PLASTICITY AFFECTS SYSTEMIC IMMUNO-METABOLISM
… of OPA1 deficiency on KCs function and the paracrine effects on hepatocytes. Under standard dietary conditions, mice selectively lacking OPA1 in KCs exhibit a metabolic substrate preference toward carbohydrates, with an immunophenotype characterized by a higher proportion of pro-resolving …
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Pancreatic Cancer: Oncomicrobes, Electric Fields, and Fluid Flow
… uninfected BxPC3 and Panc1 cells, suggesting paracrine effects. While F. nucleatum-infected nPECs exhibited a similar cytokine profile, they did not display increased proliferation or self-migration. However, conditioned media from infected nPECs enhanced BxPC3 cancer cell migration, …
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Mechanisms of pathological adipogenesis
… or its variant isoforms may have autocrine/paracrine effects in these cells. Ghrelin mRNA expression was higher in 7F2 cells treated with basal medium + 200 nM ghrelin (144.84 ± 0.58) and adipogenic medium + 200 nM ghrelin (123.07 ± 0.33) compared with cells cultured with basal medium alone …
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Recombinant DDX58 associates with SOD1 protein and selective miRNA changes in secreted EVs
… investigate DDX58 in connection to EVs and their paracrine effects. In NSC34 cells, we observed that recombinant DDX58-tGFP displays an intracellular distribution that partially reaches the organelle-enriched fraction of the endogenous Ddx58. We showed DDX58 local interactions with wt and G93A …
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ADP regulation of insulin secretion and beta-cell apoptosis
… of this dissertation were to investigate the effects of extracellular purines on insulin secretion, and apoptosis in mouse pancreatic islets and β-cells; to examine if high glucose and free fatty acids induces β-cell apoptosis via autocrine effects of ADP acting on the P2Y13 receptor; and to …
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Epicardial Adipose Tissue: Relationship with Cardiovascular Disease and the Effect of Therapeutic Interventions
… development of atherosclerosis locally due to paracrine effects, thus leading to adverse cardiovascular outcome, however, few studies have shown that EAT may exert a more systemic effect. EAT is metabolically active and secretes numerous substances associated with cardiovascular disease (CVD) …
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Oncogene-induced reprogramming of heterotypic cellular interactions
… of neighbouring wild-type cells through paracrine signalling. Despite this, the role and importance of cell-to-cell communication in KRAS- driven carcinogenesis is not well-characterised and the specific effects of different KRAS mutations are largely unknown. Importantly, different KRAS …
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PHOSPHODIESTERASE-5 INHIBITION: A NOVEL STRATEGY TO IMPROVE STEM CELL THERAPY IN THE HEART
<p>Several studies have shown cellular replacement therapy as a treatment strategy of myocardial infarction but results have been limited. Therefore, enhancing the therapeutic potential of stem cells injected into ischemic microenvironments by novel preconditioning (PC) techniques is critical for …
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Gene Therapy and Stem Cell Therapy to Improve the Outcome of Human Islet Transplantation
… potential, multi-lineage capacities, paracrine effects (trophic mediator) and immune modulatory effects, making it a great candidate for improving human islet transplantation. MSCs are mostly found in bone marrow, adipose and umbilical cord blood, are one of the most extensively …
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Endothelial NADPH oxidases as regulators of coronary microvascular dysfunction in diabetic cardiac remodeling
… (DCF/DHE staining) was performed to identify the effects of endothelial-specific Nox2 and Nox4 on diabetic cardiomyopathy. <br/><br/>To assess the effects of hyperglycaemia on EC function, human aortic ECs (HAoECs) with or without NOX4 modification were assessed for changes in gene and protein …