Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 175 for “"Paracrine"”.
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Mechanisms of microenvironmental paracrine signaling in cancer chemoresistance
… production. These data implicate endothelial paracrine signaling in the promotion of chemoresistance and elucidates the molecular control of acute vs. chronic therapy-induced cytokine secretion. Conventional chemotherapeutics such as doxorubicin can induce anti-cancer immune responses through …
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Growth Differentiation Factor 5 is a Paracrine Regulator of Sarcopenic Obesity
<p>Sarcopenic obesity attributes to skeletal muscle loss more than sarcopenia and obesity alone. Individuals with SO suffer from the comorbidity of excess body fat and concurrent muscle mass loss due to aging. Growth differentiation factors (Gdfs) have never been recognized as playing a role in …
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Additive effects among uterine paracrine factors in promoting bovine trophoblast cell proliferation
Several uterine-derived paracrine factors have been implicated as critical regulators of conceptus development in cattle, but it remains unclear how these factors work together to establish and maintain pregnancies. The primary objectives of this work were to establish if cooperative interactions …
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Role of GnIH and GnRH in Paracrine Control of Gametogenesis in Zebrafish (Danio rerio)
… function. However, the role of GnRH and GnIH as paracrine regulators of testicular and ovarian function has not been fully investigated. Variants of GnIH and GnRH peptides have been discovered in different vertebrates, including teleost. In addition, the presence of GnRH and GnIH receptors in …
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Evidence for the autocrine/paracrine regulation of tissue growth by the insulin-like growth factors
… in regulating this growth in an autocrine/paracrine manner.
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A Morphological Study of Paracrine Interactions in the Anterior Pituitary of Lactating Rats Using Immunogold Techniques
… each group (+0.56). These data indicate that a paracrine moldulation of lactotrope and luteotrope activity may exist in the anterior pituitary of the female rat.</p>
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The roles of hepatocyte growth factor family members in androgen-regulation of human hair growth. A comparison of the expression of hepatocyte growth factor family members, HGF and MSP, and their receptors, c-Met and RON, in isolated hair follicles from normal and androgenetic alopecia (balding) scalp.
… Androgens probably act by altering regulatory paracrine factors produced by the mesenchyme-derived dermal papilla. This study aimed to investigate paracrine factors involved in androgen-regulated alopecia, particularly hepatocyte growth factor (HGF) family members, by investigating their in …
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Cell culture platforms with cell-cell adhesive ligands for biomedical applications
… cytoskeleton organization, mechanotransduction, paracrine function, stem cell development, and neuronal growth. This molecule is an ideal candidate that can be incorporated into biomaterials to mimic cell-cell interactions. Recent efforts incorporated N-cadherin as well as other cell-cell …
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An in Vitro Study of Cellular Cardiomyoplasty: Structural and Functional Interactions of Non-cardiomyocytes and Cardiomyocytes
… properties. Our results indicate that (1) that paracrine factors secreted by cardiac fibroblasts could contribute to the progression of fibrotic cardiac disease, (2) that there may be a crosstalk mechanism between CFs and cardiomyocytes that prevents this paracrine action to occur in a healthy …
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Mesenchymal stem cell therapy for the treatment of myocardial infarction
… AMI. In addition, this thesis investigated the paracrine factors secreted by MSC, in particular focusing on the effect on cardiac repair of a novel MSC-paracrine factor SPARCL1. In summary this work provides new insight into the mechanism by which MSC may be deleterious when delivered by an IC …
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The Epicardium as the Conductor of Cardiovascular Cells in Cardiac Regeneration
… the observed benefits of co-transplantation is paracrine-mediated effects of the epicardium towards CMs and endothelial cells (EC). While RNA sequencing data has been used to identify putative players in hESC-EPIs, little is known about their involvement in mediating hESC-CM maturation and …
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Autocrine mechanisms of action of insulin-like growth factor-I (IGF-I) and hormonal regulation of expression of IGF-finding proteins in mammary epithelial cells
… epithelial cells through an autocrine and/or paracrine pathway, several cell lines were developed expressing an ovine exon-2 containing IGF-I cDNA under the control of the mouse mammary tumor virus-long terminal repeat (pMMTV-IGF-I), early simian virus (pSV40-IGF-I), and herpes simplex …
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Effects of HOXB4 downstream targets on the haemopoietic differentiation of pluripotent stem cells
… haemopoietic differentiation of mouse ESCs in a paracrine manner. Microarray analysis identified a number of secreted factors upregulated by HOXB4 potentially mediating this paracrine effect. The aim of this study was to assess whether these factors alone and/or in combination can enhance the in …
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Investigation of efficacy and mechanisms of action in mesenchymal stromal cell therapy for chronic lung diseases
… that have become the focus of research due to paracrine mediated tissue reparative and protective effects. This study has examined the use of MSC for the treatment of inflammatory and fibrotic lung diseases, specifically Chronic Obstructive Pulmonary Disease (COPD) and Idiopathic Pulmonary …
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Localized HB-EGF signaling and Connexin43 decrease in the myocardium
… affect tissue remodeling through autocrine and paracrine mechanisms. Recent evidence indicates that hypertrophic signaling in cardiomyocytes is induced through transactivation of the epidermal growth factor (EGF) receptor by heparin-binding EGF (HB-EGF). Here it is shown that HB-EGF operates in …
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Role of the interaction of proHB-EGF with heparan sulfate proteoglycans
… (HB-EGF) exhibits activity as a juxtacrine, paracrine, and autocrine ligand for the epidermal growth factor receptor (EGFR), and possesses the ability to bind heparan sulfate proteoglycans (HSPGs). The interaction of HB-EGF with HSPGs has been previously studied only with the soluble …
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The exploitation of neuronal survival factors in Burkitt’s lymphoma and germinal centre B cells
… was to question FDCs as potential providers of paracrine neurotrophin signalling to Burkitt’s lymphoma B cells. Neurotrophin and neurotrophin receptor expression was detected by flow cytometry, confocal microscopy, reverse transcription polymerase chain reaction (PCR) and real time PCR methods. …
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