Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 103 for “"Paracetamol"”.
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Paracetamol metabolism in postoperative patients
… 50 years, there is still much to learn about paracetamol. Postoperative analgesic regimens that maintain good pain control while minimising exposure to opiates are beneficial and paracetamol has had a resurgence in this role since an IV formulation came to market. However there is evidence to …
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Terhesség során alkalmazott paracetamol hatása a magzatra
… a legszélesebb körben alkalmazott készítmények paracetamol tartalmúak. Diplomamunkám céljául tűztem ki, hogy megvizsgáljam azt, hogy a terhesség alatt szedett paracetamol káros lehet-e a magzatra nézve. Dolgozatomban az anyában végbemenő élettani, fiziológiai változások kerülnek bemutatásra, …
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Paracetamol intoxications: A population-based study in Iceland
Background: Paracetamol is the most common cause of acute liver failure (ALF) in the US and many countries in Europe. Most data on paracetamol toxicity originate from liver transplant centres and tertiary referral institutions. The proportion of patients with paracetamol overdose who develop liver …
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A systems toxicology framework for improving the identification of paracetamol overdose
Paracetamol (APAP) overdose is the leading cause of acute liver failure and a concerning global health issue. However, the current clinical treatment framework is heavily criticized for its sub-optimality. Within this thesis, a systems toxicology approach is taken in an attempt to provide further …
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Engineering composite particles to overcome the poor pharmaceutical performance of paracetamol
… a high dose of a poorly compactible drug such as paracetamol must be used. Paracetamol is a widely used analgesic drug. The monoclinic form is usually selected in the pharmaceutical industry and is the commercially available form because it is thermodynamically stable at room temperature and …
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Análisis isobolográfico de la asociación paracetamol con ibuprofeno en dolor orofacial experimental
… fue determinar la actividad antinociceptiva del paracetamol y el ibuprofeno, y el grado de interacción entre ellos, utilizando el análisis isobolográfico en la prueba de la formalina orofacial en ratones. Se utilizaron alrededor de 200 ratones machos de la cepa CF/1 (mus musculus). El estudio se …
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N-Acetylcysteine for non-paracetamol drug-induced liver injury: A systemic review
… to be of benefit in management of DILI due to paracetamol overdose and may also be useful in the management of non-paracetamol DILI. Our objective was to systematically review evidence for the use of NAC as a therapeutic option for non-paracetamol DILI. Methods: We conducted a systematic review …
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"But it's just paracetamol" : caregivers ability to administer over-the-counter painkillers to their children with the information provided
… of popular OTC painkillers (specifically paracetamol) to their children, based on information from labels, medication inserts and/or patient information leaflets (PILs).
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Korrelation des Polymorphismus der Uridindiphosphat-Glukuronyltransferase Isoform 1A1 mit der Glukuronidierung von Bilirubin und Paracetamol und der klinischen Diagnose des Gilbert Syndroms
… in der Glukuronidierungskapazität von Paracetamol zwischen Probanden mit homozygot wildtypischer, homozygot mutierter und heterozygoter Allelkombination konnte nicht nachgewiesen werden. Deshalb scheint die UGT1A1 nicht das für Para-cet-amol verantwortliche Isoenzym zu sein. Die …
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Clinical outcomes in patients with paracetamol ingestion treated with a two-bag n-acetylcysteine regimen in the emergency centre of khayelitsha hospital
Introduction: Paracetamol is frequently ingested for intentional self-poisoning. N-acetylcysteine (NAC) is administered to patients at risk of developing hepatotoxicity and was historically administered using a three-bag intravenous regimen. A change towards a two-bag NAC regimen was initiated at …
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The use of scintigraphy to study gastric emptying, motility and small intestinal transit in patients who have ingested a selection of common poisons
… 31), carbamazepine (n = 15), phenytoin (n = 12), paracetamol (n = 29) and opioid-paracetamol mixtures (n = 17). They received standard hospital management of which sorbitol was not a part. Part 2 consisted of sixty-one patients who had sorbitol added to their treatment. These patients had taken …
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Die stabiliteit van parasetamol in vaste doseringsvorme
… to: i) develop a stability indicating method for paracetamol tablets; ii) formulate and prepare different paracetamol tablets and to compare the bioavailability and physicopharmaceutical properties of these tablets and presently registered tablets; iii) evaluate the stability of the above …
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Development of circulating microRNA in drug-induced liver injury: studies in humans and zebrafish
… that can be used as biomarkers in patients with paracetamol-induced liver injury. Whether the miRNAs discovered in humans could be back-translated to zebrafish with the aim of developing a liver toxicity model to replace rodent use was also investigated. First, the miRNA signature of DILI induced …
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Amperometric responses of some biosensor-related analytes at electrodes coated with semipermeable polymer layers: a comparative study /
… responses of hydrogen peroxide, ascorbate and paracetamol have been studied at platinum electrodes coated with Nafion or electropolymerized polypyrrole and poly(o-phenylenediamine) and polyaniline (PANI) layers. Among the three layers studied, the Nafion layer shows superior properties. It …
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A study of the effect of Si:Al Ratio and ion-exchange on the ability of the zeolite ZSM-5 to adsorb common analgesics from waste water
… ZSM-5’s effectiveness at removing the analgesics paracetamol, aspirin and ibuprofen lysine from aqueous solution was investigated. ZSM-5’s Si:Al ratio and charge balancing cation were also altered to ascertain the effects these attributes had on its ability to remove the analgesics from aqueous …
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Pharmaceutical occurrence, distribution and degradation in rural wastewaters and surface waters in Scotland
… compounds were selected for this work: paracetamol, diclofenac and ibuprofen (analgesics/nonsteroidal anti-inflammatory drugs); clarithromycin and trimethoprim (antibiotics); carbamazepine and fluoxetine (psychoactive drugs); and 17α-ethynylestradiol (synthetic hormone).<br/>Overall, …
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Investigating human pharmaceutical compounds present in municipal and hospital wastewaters and options for their removal
… wastewater treatment plants (MWWTPs) were for paracetamol, naproxen and bezafibrate (> 1 μg/L), followed by carbamazepine, atenolol, lidocaine, sulfamethoxazole and NACS (<1 μg/L). In hospital wastewater treatment plants (HWWTPs), the highest concentrations measured were for paracetamol and …
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