Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"Para-aminobenzoic acid"”.
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Inhibitor studies on para-aminobenzoic acid synthase.
Para-aminobenzoic acid (PABA) synthase is a three-subunit enzyme system that catalyses the conversion of chorismic acid top-aminobenzoic acid in plants and microorganisms. P ABA is then incorporated into folic acid an essential nutrient for mammals and utilised in the transfer of one-carbon units. …
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Genetic and phenotypic analyses of auxotrophs requiring aromatic amino acids and vitamins in Streptomyces coelicolor
… auxotrophic requirement for aromatic amino acids were mapped relative to closely linked genetic markers. Based on four-point reciprocal crosses mutants were found to map in at lea.st two locations. One mutant mapped between proA and hisC while three fell between argA and hisE. Another mutant …
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Structural studies to inform antimicrobial drug discovery and the basis of immunity against T6 effectors
… PabC is involved in the production of para-aminobenzoic acid on the path to folate. Comparisons with previously solved PabC structures identified a spatially conserved tyrosine residue in the active site and suggest that a re-evaluation of a published mechanism is warranted.<br/>Part …
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The mechanistic basis of susceptibility and resistance to the antitubercular drug para-aminosalicylic acid
… causes severe side-effects. The antimicrobial para-aminosalicylic acid (PAS) is used to treat drug-resistant M. tuberculosis infections. Despite the use of PAS to treat M. tuberculosis for over 70 years, the biochemical mechanisms which govern PAS susceptibility and resistance in M. …