Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"Par6"”.
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Opposing Crosstalk between Rho1 and Cdc42 in Epithelial Morphogenesis
… by inhibiting DE-cadherin endocytosis in a Cdc42/Par6-dependent manner. In contrast, depletion of Rho1 in single cells decreased apical tension, and Rok and Myosin were necessary downstream of Rho1 to sustain apical cell tension. Second, clonal analysis in the pupal eye epithelium further …
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The Effects of Atypical Protein Kinase C on TGFβ Signalling
… alters the phosphorylation and degradation of Par6, which in turn affects TGFβ induced EMT and migration. Finally, I examined global gene expression changes in aPKC silenced cells - and related these effects to altered Smad nuclear accumulation. Notably, we also found that these cells …
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The Nrg Growth Factors and Their Receptor ErbB4 in the Developing Brain: Delineation of Nrg3 Expression and Neuritogenesis
… ErbB4 with members of the Par polarity complex (Par6, Par3, aPKC, and Cdc42), a group of proteins important for radial glial morphology, neuronal migration, and axonal specification. Collectively, the findings of this thesis highlight biological processes of the Nrgs and ErbB4 in the developing …
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Actions of alpha-chimaerins in mechanisms relevant to dendritic spine formation and neurodegeneration
… the adaptor protein p35 and the polarity protein PAR6. Finally, I have shown that inhibition of a pathway involving the Rho-associated coiled-coil containing protein kinase (ROCK) reverts circularisation induced by a1- chimaerin, and that a blocking peptide based on the CTD may be employed to …
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Quantitative super-resolution imaging of cell polarity proteins using DNA-PAINT
… of three apical polarity proteins (aPKC, Crumbs, Par6) in the fruit fly egg chambers revealed that they form mesoscopic-sized clusters along the cell junctions. In order to analyse these clusters in a quantitative manner, I collaborated with Leila Muresan to develop an image analysis pipeline. My …