Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 39 for “"Papillomaviruses"”.
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Cutaneous Human Papillomaviruses
Human papillomaviruses (HPVs) exist as more than 100 distinct types. Variants of HPVs appear to be common findings while HPV subtypes have been considered rare. New information about subtypes has recently been reported by us. Our characterisation of subtype HPV38b[FA125] and the identification of …
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Human Papillomaviruses in oesophageal cancer
Bibliography: p. 207-213.
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Human papillomaviruses of skin and genital lesions
Around 5% of all cancer cases worldwide are caused by human papillomavirus (HPV) which has been established as the cause of cervical cancer and genital warts (condylomas). Cutaneous HPV types have been weakly associated with non-melanoma skin lesions such as squamous cell carcinoma (SCC) and …
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Human papillomaviruses in skin cancer and cervical cancer
The causal relationship between persistent genital infections with human papillomavirus (HPV) and development of cervical cancer is well established. In contrast, the significance of infections with cutaneous HPV for development of non-melanoma skin cancer (NMSC) is not well understood. We have …
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Cloning and Molecular Characterization of Novel Animal Papillomaviruses
Papillomaviruses represent a diverse group of species and tissue specific viruses which are important agents of disease, including some cancers. This thesis describes the cloning and molecular characterization of five new animal papillomaviruses: an equine cutaneous papillomavirus (EqPV); a canine …
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Novel Cutaneous Human Papillomaviruses and Biomarkers in the Skin Lesions
Non-melanoma skin cancer (NMSC), comprising of squamous cell carcinoma (SCC) and basal cell carcinoma (BCC), is the most prevalent cancer amongst Caucasians. The main risk factor for the development of NMSC is UV-irradiation but human papillo-mavirus (HPV) might be a co-factor. We extended the …
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MOLECULAR PERSPECTIVES OF THE EPIDEMIOLOGY, EVOLUTION AND TAXONOMY OF HUMAN PAPILLOMAVIRUSES
… virus evolution, taxonomy, and identification of papillomaviruses are inextricably linked to the wider issues of papillomavirus epidemiology. In our studies, we have designed experiments and databases for the reliable assessment of HPV genomes from lesions, through the use of Polymerase Chain …
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Dental hygienists' role in education of oropharyngeal cancers caused by human papillomaviruses: a thesis
<p>"This qualitative design study collected Likert style survey data to describe feelings, perceptions, and attitudes of dental hygienists about their knowledge about oral HPV and its associated risks for OPC. The research quantitatively analyzed the dental hygienists responses from the survey to …
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E7 PROTEINS OF HIGH-RISK (TYPE 16) AND LOW-RISK (TYPE 6) HUMAN PAPILLOMAVIRUSES REGULATE p130 DIFFERENTLY
Human papillomaviruses (HPVs) are one of the most common causes of sexually transmitted disease in the world. HPVs are divided into high-risk (HR) or low-risk (LR) types based on their oncogenic potential. HPVs 16 and 18 are considered HR types and can cause cervical cancer. HPVs 6 and 11 are …
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Quasivirus Infection Model Identifies a Novel Role for Protein Arginine Methyltransferase 1 in the HPV Lifecycle
Papillomaviruses (PVs) are a diverse family of small (5.6kb-8.6kb) double stranded DNA viruses. PVs are non-enveloped viruses with histone wrapped genomes. To date over 700 PVs have been identified in a wide range of hosts including mammals, birds, reptiles, and fish. Over 400 HPVs have been …
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Investigating Early Lesion Formation Following Papillomavirus Infection Using a Mouse Model and Cell Culture
Papillomaviruses (PV) are small non-enveloped double-stranded DNA tumour viruses, which are able to infect more than 80 different host species. They are a diverse group with over 400 types discovered, of which almost half infect humans. Human papillomaviruses have been linked to a myriad of …
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Transcriptional Regulation Mediated by Human Papillomavirus E2 Protein
Human papillomaviruses (HPVs) are one of the most common sexually transmitted pathogens in the world. The American Social Health Association reports that there are at least 20 million Americans already infected with HPVs and approximately 5.5 million new cases are reported annually. In HPVs, …
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HPV E6 inhibits E6AP to regulate epithelial homeostasis by modulating keratinocyte differentiation commitment and YAP1 activation
Human papillomaviruses (HPV) typically cause chronic infections by modulating homeostasis of infected basal cell to ensure persistence. Using FUCCI and cell-cell competition assays, we established the role of two common viral targets of low-risk and high-risk E6 proteins, E6AP and NHERF1, on the …
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Small Molecule Inhibitors of HPV16 E6
<p>High-risk human papillomaviruses (HR-HPVs) cause nearly all cases of cervical cancer. HPV 16 E6, one of two viral oncogenes, protects cells from apoptosis by binding to and accelerating the degradation of several apoptotic proteins, including caspase 8 and p53. We proposed that blocking the …
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Real time PCR and fluorescent in situ hybridization in the detection of the physical tsate of human papillomavirus 16 and 18 in paraffin embedded cervical tissue
Human papillomaviruses (HPV) are the etiologic agents of most cervical dysplasia and all cervical carcinoma. Integration of high risk HPV into the human genome is thought to be a critical event in the progression from cervical dysplasia to invasive cervical carcinoma. The ability to use molecular …
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Inhibition of the transcription factor AP-1 in cervical cancer
… of the E6 and E7 oncoproteins of high-risk Human Papillomaviruses (HPV) that are etiologically associated with cervical cancer. The c-Jun and Jun B components of AP-I were shown to be expressed at higher levels in cervical cancer patients compared to nonnal patient tissue while Jun D levels were …
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Pseudovirions in the Study of Papilloma- and Polyomaviruses
… As there are more than 150 types of Human papillomaviruses (HPV) and at least 10 Human polyomaviruses (HPyV), the study of antibodies to these virus families require high-throughput methods. Although it is difficult to produce infectious virus stocks of these viruses, so-called …
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Conserved Residues in Murine Papillomavirus E2 Regulate the Viral Life Cycle
Papillomaviruses (PVs) are small, non-enveloped DNA viruses that infect the stratified epithelia. Once an infection is initiated, the virus must successfully navigate the three stages of its life cycle: establishment, maintenance, and vegetative amplification. A major mechanism of regulating this …
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Longitudinal Keratinocyte Proliferation Induced by Human Papillomavirus 16E6 and NFX1-123 Partnership
High-risk human papillomaviruses (HPV) cause cervical, anogenital, and head and neck cancers. Despite the availability of preventive HPV vaccines, their poor uptake leaves most men and women at risk for these cancers, many of which remain common globally and others that are increasing domestically. …
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